Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

c‑Myc maintains the self‑renewal and chemoresistance properties of colon cancer stem cells

(2019) Huan‑Le Zhang et al.   Oncology Letters

The endosomal protein CEMIP links Wnt signaling to MEK1-ERK1/2 activation in Selumetinib-resistant intestinal organoids

(2018) Hong-Quan Duong et al.   CANCER RESEARCH

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

(2018) Moon Jong Kim et al.   DEVELOPMENTAL CELL

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

(2018) Tatsuya Usui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids

(2018) Changlong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

(2018) Franz X. Schaub et al.   Cell Systems

Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer

(2018) Mohamed Elbadawy et al.   Cancers

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Emerging roles of Myc in stem cell biology and novel tumor therapies

(2018) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Stem cell-derived organoids and their application for medical research and patient treatment

(2017) Sina Bartfeld et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma

(2016) Z. Y. Xu-Monette et al.   CLINICAL CANCER RESEARCH

c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines

(2016) G. L. Gravina et al.   RADIATION RESEARCH

Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment

(2016) Tatsuya Usui et al.   Stem Cells International

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

PRDM1, a Tumor-Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells

(2015) Ho-Bum Kang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting c-MYC in Platinum-Resistant Ovarian Cancer

(2015) J. M. Reyes-Gonzalez et al.   MOLECULAR CANCER THERAPEUTICS

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Telomere-Centromere-Driven Genomic Instability Contributes to Karyotype Evolution in a Mouse Model of Melanoma

(2015) Amanda Gonçalves dos Santos Silva et al.   NEOPLASIA

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

(2014) Markus E. Diefenbacher et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunohistochemistry for Myc Predicts Survival in Colorectal Cancer

(2014) Christopher W. Toon et al.   PLoS One

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues

(2014) Nathiya Muthalagu et al.   Cell Reports

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

c-MYC-Induced Genomic Instability

(2014) A. Kuzyk et al.   Cold Spring Harbor Perspectives in Medicine

Molecular aspects of cancer cell resistance to chemotherapy

(2013) Magali Rebucci et al.   BIOCHEMICAL PHARMACOLOGY

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

(2012) M. Kaur et al.   CANCER RESEARCH

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

(2011) Felipe de Sousa E Melo et al.   Cell Stem Cell

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance

(2011) S. Pyndiah et al.   Science Signaling

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MYCN-regulated microRNAs repress estrogen receptor-  (ESR1) expression and neuronal differentiation in human neuroblastoma

(2010) J. Loven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule perturbation of competing interactions between c-Myc and Max

(2008) Ariele Viacava Follis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers

(2008) S. K. Chan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

c-Myc: Linking Transformation and Genomic Instability

(2008) Edward Prochownik   CURRENT MOLECULAR MEDICINE

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS