Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer

Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma

(2016) Shigeki Sekine et al.   JOURNAL OF PATHOLOGY

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

(2016) Babita Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates  -Catenin Signaling and Tumorigenesis in Multiple Cancer Types

(2015) C. Chartier et al.   CANCER RESEARCH

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

(2015) Elaine E. Storm et al.   NATURE

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

Porcupine inhibitor suppresses paracrine Wnt-driven growth ofRnf43;Znrf3-mutant neoplasia

(2015) Bon-Kyoung Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors.

(2015) Robert Callahan et al.   Oncotarget

The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans

(2014) L. L. Moffat et al.   DEVELOPMENT

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

(2014) Bernd Kinzel et al.   DEVELOPMENTAL BIOLOGY

RSPO fusion transcripts in colorectal cancer in Japanese population

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

Integrated genomic characterization of adrenocortical carcinoma

(2014) Guillaume Assié et al.   NATURE GENETICS

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

(2014) X Gong et al.   ONCOGENE

RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

(2014) Changjie Wu et al.   Nature Communications

Reconstitution of R-Spondin:LGR4:ZNRF3 Adult Stem Cell Growth Factor Signaling Complexes with Recombinant Proteins Produced in Escherichia coli

(2013) Heather E. Moad et al.   BIOCHEMISTRY

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

(2013) Yang Xie et al.   EMBO REPORTS

The structural basis of R-spondin recognition by LGR5 and RNF43

(2013) P.-H. Chen et al.   GENES & DEVELOPMENT

Structural basis for R-spondin recognition by LGR4/5/6 receptors

(2013) D. Wang et al.   GENES & DEVELOPMENT

The Development of Highly Potent Inhibitors for Porcupine

(2013) Xiaolei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Whole-exome sequencing of pancreatic neoplasms with acinar differentiation

(2013) Yuchen Jiao et al.   JOURNAL OF PATHOLOGY

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

(2013) Weng Chuan Peng et al.   PLoS One

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

(2013) Kai Xu et al.   STRUCTURE

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

(2013) Matthias Zebisch et al.   Nature Communications

Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance

(2013) Adrienne L. Watson et al.   Cancer Discovery

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

(2013) Weng Chuan Peng et al.   Cell Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The R-spondin family of proteins: Emerging regulators of WNT signaling

(2012) Yong-Ri Jin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

RNF43is a tumour suppressor gene mutated in mucinous tumours of the ovary

(2012) Georgina L Ryland et al.   JOURNAL OF PATHOLOGY

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

The R-spondin protein family

(2012) Wim BM de Lau et al.   GENOME BIOLOGY

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells

(2011) Malgorzata Klauzinska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function

(2009) Sheng-Jian Li et al.   CELLULAR SIGNALLING

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

(2009) E. Cadieu et al.   SCIENCE

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

(2009) T. K. Starr et al.   SCIENCE

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

(2008) O. Kazanskaya et al.   DEVELOPMENT

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL