Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

(2020) Franziska Wandrer et al.   Cell Death & Disease

Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases

(2019) Sujuan Yang et al.   Cell Death & Disease

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer’s Disease

(2019) Natalia Ortí-Casañ et al.   Frontiers in Neuroscience

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

(2019) Juliane Medler et al.   Cell Death & Disease

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury

(2019) Marcus J. Gerald et al.   CNS Neuroscience & Therapeutics

Systemic inhibition of soluble TNF with XPro1595 exacerbates a post-spinal cord injury depressive phenotype in female rats

(2019) Kaitlin Farrell et al.   JOURNAL OF NEUROTRAUMA

Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc

(2019) Fabian Richter et al.   mAbs

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

(2019) Roman Fischer et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

(2019) Madhu Sudhana Saddala et al.   Journal of Translational Medicine

Noncompetitive inhibitors of TNFR1 probe conformational activation states

(2019) Chih Hung Lo et al.   Science Signaling

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

(2019) Roman Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

(2019) Minna Yli-Karjanmaa et al.   Frontiers in Neuroscience

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

(2019) Pernille M. Madsen et al.   BRAIN BEHAVIOR AND IMMUNITY

Attenuating neurogenic sympathetic hyperreflexia robustly improves antibacterial immunity after chronic spinal cord injury

(2019) Eugene Mironets et al.   JOURNAL OF NEUROSCIENCE

Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity

(2019) Eric M. Tam et al.   Science Translational Medicine

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

(2019) Maria Elizabeth De Sousa Rodrigues et al.   Alzheimers Research & Therapy

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

(2019) Tanja Padutsch et al.   Frontiers in Pharmacology

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

(2018) Alice Borghi et al.   BIOCHEMICAL PHARMACOLOGY

Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

(2018) Vanessa Lamontain et al.   Cellular & Molecular Immunology

TNF activity and T cells

(2018) Amit K. Mehta et al.   CYTOKINE

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

The role of lymphotoxin-α in rheumatoid arthritis

(2018) Tomohiro Hirose et al.   INFLAMMATION RESEARCH

Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons

(2018) Rong Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury

(2018) Eugene Mironets et al.   JOURNAL OF NEUROSCIENCE

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

(2018) Alastair Proudfoot et al.   THORAX

Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells

(2018) Meike Hutt et al.   Oncotarget

IgG-single-chain TRAIL fusion proteins for tumour therapy

(2018) Martin Siegemund et al.   Scientific Reports

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

(2018) Roman Fischer et al.   Arthritis & Rheumatology

Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment

(2018) Valentina Pegoretti et al.   Frontiers in Immunology

The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells

(2018) Tianzhen He et al.   Frontiers in Immunology

TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors

(2018) Yuqiao Sheng et al.   Frontiers in Immunology

The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells

(2018) Lin-Lin Ye et al.   Frontiers in Immunology

Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity

(2018) Fabian Richter et al.   mAbs

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

(2018) Jun Wang et al.   Scientific Reports

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

(2018) Sarah K. Williams et al.   Scientific Reports

Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome

(2018) H Torrey et al.   LEUKEMIA

TNFR1 inhibition is therapeutic for neuropathic pain in males but not females

(2018) Tania del Rivero et al.   PAIN

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

(2018) Kamar-Sulu N. Atretkhany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification

(2017) Masaki Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund’s Adjuvant by a TRPV1-dependent mechanism in mice

(2017) Krzysztof Lis et al.   Pharmacological Reports

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

TNFR2: A Novel Target for Cancer Immunotherapy

(2017) Éva S. Vanamee et al.   TRENDS IN MOLECULAR MEDICINE

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

(2017) Roman Fischer et al.   Scientific Reports

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2017) Han Gao et al.   Cell Reports

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

(2017) Tobias Schmid et al.   Frontiers in Immunology

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

(2017) Chih Hung Lo et al.   SLAS Discovery

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice

(2016) Ditte Gry Ellman et al.   MEDIATORS OF INFLAMMATION

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

(2016) P. Bru nker et al.   MOLECULAR CANCER THERAPEUTICS

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response

(2016) Phillip D. Fromm et al.   Frontiers in Microbiology

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

(2016) Xin Chen et al.   Scientific Reports

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VHdomain antibody antagonist of tumour necrosis factor-α receptor 1

(2015) J. C. Cordy et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2

(2015) M. Inoue et al.   JOURNAL OF CELL SCIENCE

Transmembrane TNF–TNFR2 Impairs Th17 Differentiation by PromotingIl2Expression

(2015) Patrick G. Miller et al.   JOURNAL OF IMMUNOLOGY

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension

(2015) Laura J. Goodall et al.   PLoS One

FRI0231 Atrosab, a humanized antibody directed against tnf-receptor 1, hold great promises for the treatment of rheumatoid arthritis

(2014) E. Guenzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

(2014) Anna Dellarole et al.   BRAIN BEHAVIOR AND IMMUNITY

Lymphotoxin and TNF: How it all began—A tribute to the travelers

(2014) Nancy H. Ruddle   CYTOKINE & GROWTH FACTOR REVIEWS

Anti-TNF therapy: past, present and future

(2014) C. Monaco et al.   INTERNATIONAL IMMUNOLOGY

Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

(2014) Sophie Steeland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity

(2014) A. Krippner-Heidenreich et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Hjelm Clausen et al.   Journal of Neuroinflammation

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

(2014) Hans G Novrup et al.   Journal of Neuroinflammation

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

(2014) F Van Hauwermeiren et al.   Mucosal Immunology

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain

(2014) Xiao-Yan Zeng et al.   NEUROSCIENCE LETTERS

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis

(2014) Sarah K. Williams et al.   PLoS One

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study)

(2014) William P Kennedy et al.   ARTHRITIS RESEARCH & THERAPY

TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress

(2013) Olaf Maier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo

(2013) David A. Horwitz et al.   CLINICAL IMMUNOLOGY

Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

(2013) Roman Fischer et al.   GLIA

Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1

(2013) M. C. Holland et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

(2013) Fabian Richter et al.   PLoS One

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

(2012) Jigisha R. Patel et al.   ACTA NEUROPATHOLOGICA

No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF- B activity

(2012) A. C. Schmukle et al.   JOURNAL OF CELL SCIENCE

Tumor Necrosis Factor Activation of Vagal Afferent Terminal Calcium Is Blocked by Cannabinoids

(2012) R. C. Rogers et al.   JOURNAL OF NEUROSCIENCE

The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand

(2012) C. Richter et al.   MOLECULAR AND CELLULAR BIOLOGY

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning

(2011) Yasuhiro Abe et al.   BIOMATERIALS

Heterogeneity reduces sensitivity of cell death for TNF-Stimuli

(2011) Monica Schliemann et al.   BMC Systems Biology

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

TNFR2 on non-haematopoietic cells is required for Foxp3+Treg-cell function and disease suppression in EAE

(2011) Niki Tsakiri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

Novel TNF-α Receptor 1 Antagonist Treatment Attenuates Arterial Inflammation and Intimal Hyperplasia in Mice

(2011) Manabu Kitagaki et al.   Journal of Atherosclerosis and Thrombosis

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

(2011) Roman Fischer et al.   PLoS One

Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors

(2010) Margarita Gerken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2

(2010) Verena Boschert et al.   CELLULAR SIGNALLING

Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway

(2010) Roman Fischer et al.   CELLULAR SIGNALLING

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF

(2010) Vitaly Ablamunits et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis

(2010) Maria L. Olleros et al.   JOURNAL OF HEPATOLOGY

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

(2010) Kirstin A. Zettlitz et al.   mAbs

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain

(2010) C. Geis et al.   NEUROSCIENCE

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2

(2010) Ling Zhang et al.   PAIN

ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ treg cells and induces sustained amelioration of collagen-induced arthritis

(2009) Clare A. Notley et al.   ARTHRITIS AND RHEUMATISM

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

(2009) Hiroko Shibata et al.   BIOMATERIALS

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

Antagonists of TNF action: clinical experience and new developments

(2009) Roland E Kontermann et al.   Expert Opinion on Drug Discovery

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

(2009) Tetsuya Nomura et al.   JOURNAL OF CONTROLLED RELEASE

A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

(2009) Roland E. Kontermann et al.   JOURNAL OF IMMUNOTHERAPY

Dominant‐Negative Tumor Necrosis Factor Protects fromMycobacterium bovisBacillus Calmette‐Guérin (BCG) and Endotoxin‐Induced Liver Injury without Compromising Host Immunity to BCG andMycobacterium tuberculosis

(2009) Maria L. Olleros et al.   JOURNAL OF INFECTIOUS DISEASES

Nanoscale Arrangement of Apoptotic Ligands Reveals a Demand for a Minimal Lateral Distance for Efficient Death Receptor Activation

(2009) Julia Ranzinger et al.   NANO LETTERS

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

(2008) Robbert G. van der Most et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models

(2008) Hiroko Shibata et al.   CYTOKINE

Structure–Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant

(2008) Yohei Mukai et al.   JOURNAL OF MOLECULAR BIOLOGY

TNF-α mediates neuroprotection against glutamate-induced excitotoxicity via NF-κB-dependent up-regulation of KCa2.2 channels

(2008) Amalia M. Dolga et al.   JOURNAL OF NEUROCHEMISTRY

Endogenous Tumor Necrosis Factor   (TNF ) Requires TNF Receptor Type 2 to Generate Heat Hyperalgesia in a Mouse Cancer Model

(2008) C. E. Constantin et al.   JOURNAL OF NEUROSCIENCE

Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats

(2008) Melissa K McCoy et al.   MOLECULAR THERAPY

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

(2008) L. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS