TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells

(2015) Xin Chen et al.   FASEB JOURNAL

Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8+ T Cells in Mice With Colitis

(2015) Shivesh Punit et al.   GASTROENTEROLOGY

The importance of co-stimulation in the orchestration of T helper cell differentiation

(2015) Jonathan M Coquet et al.   IMMUNOLOGY AND CELL BIOLOGY

Transmembrane TNF–TNFR2 Impairs Th17 Differentiation by PromotingIl2Expression

(2015) Patrick G. Miller et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation

(2014) Bharat B. Aggarwal   Arthritis & Rheumatology

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen-Induced Arthritis

(2014) Fiona E. McCann et al.   Arthritis & Rheumatology

Paradoxical immune-mediated inflammation in inflammatory bowel disease patients receiving anti-TNF-α agents

(2013) Gionata Fiorino et al.   AUTOIMMUNITY REVIEWS

Targeting TNF-α for the treatment of inflammatory bowel disease

(2013) Thomas Billiet et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

Harms of TNF inhibitors in rheumatic diseases: a focused review of the literature

(2013) Archana Jain et al.   Immunotherapy

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Intrinsic TNF/TNFR2 Interactions Fine-Tune the CD8 T Cell Response to Respiratory Influenza Virus Infection in Mice

(2013) Michael E. Wortzman et al.   PLoS One

TNFR2 Expression on CD25hiFOXP3+ T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors

(2013) Chindu Govindaraj et al.   Frontiers in Immunology

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

(2013) Takanori So et al.   Frontiers in Immunology

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

(2013) Denise L. Faustman et al.   Frontiers in Immunology

Balance between NF- B p100 and p52 Regulates T Cell Costimulation Dependence

(2012) M. L. Giardino Torchia et al.   JOURNAL OF IMMUNOLOGY

Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages

(2011) Raja Atreya et al.   GASTROENTEROLOGY

The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immunodeficiency

(2010) M. B. FISCHER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells

(2010) Yuh-Ching Twu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

OX40 is required for regulatory T cell–mediated control of colitis

(2010) Thibault Griseri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Lack of TNFR2 expression by CD4+T cells exacerbates experimental colitis

(2009) Johanna Dayer Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis

(2009) RoseMarie Stillie et al.   INFLAMMATORY BOWEL DISEASES

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY