Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Wojciech Jachec, Wiktoria Stanek, Bartosz Stanek, Monika Szoltysik, Tomasz Techmanski, Maja Hasterok, Celina Wojciechowska
Summary: This study aimed to compare the levels of adipokines, TNF-alpha, and soluble receptors in heart failure patients with different BMI. The study found that obese patients had the lowest NT-proBNP concentrations and higher leptin levels. TNF-alpha concentrations were positively correlated with sTNFr1 in all groups. Higher levels of sTNFr1 were associated with higher sTNFr2 and CRP levels. Obese patients may respond better to anti-TNF therapy.
Article
Hematology
Tiantian Chu, Shuhong Hu, Jiaqian Qi, Xueqian Li, Xiang Zhang, Yaqiong Tang, Meng Yang, Yang Xu, Chang-Geng Ruan, Yue Han, De-Pei Wu
Summary: This study investigated the effects of TNF alpha on megakaryocyte and platelet generation and found that TNF alpha had differential effects on their production at different concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Article
Food Science & Technology
Jong Yeon Park, Bich Hang Do, Ju-Seung Lee, Hyun Cheol Yang, Anh Ngoc Nguyen, Martin Krupa, Chong Jai Kim, Yeon Jin Jang, Han Choe
Summary: The study found that recombinant crotamine has significant antinociceptive and anti-inflammatory effects, which are not related to the opioid receptor. Additionally, the effects of intraperitoneal or intraplantar recombinant crotamine are related to TNF-alpha.
Article
Multidisciplinary Sciences
Olga Zbodakova, Karel Chalupsky, Lenka Sarnova, Petr Kasparek, Marketa Jirouskova, Martin Gregor, Radislav Sedlacek
Summary: ADAM10 and ADAM17 play concurrent roles in liver regeneration and fibrosis, affecting growth receptor signaling and TNF RI release. Their pathological roles are context-dependent, with antagonistic effects observed in some models but not others.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Isabel Belinchon Romero, Almudena Mateu Puchades, Miguel Ribera Pibernat, Diana. P. Ruiz Genao, Pablo de la cueva Dobao, Jose Manuel Carrascosa
Summary: This comprehensive systematic literature review aimed to gather information on the criteria used to define anti-TNF-alpha failure in the management of psoriasis. The study found that the criteria varied across studies, with the main reasons for treatment failure being lack or loss of efficacy and safety-related problems. The review also outlined the subsequent treatments administered, including switching to other anti-TNF-alpha drugs and using IL-inhibitors.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kun Yu, Chengxin Yu, Liping Jiao, Kun Miao, Li Ni, Xiaoquan Rao, Ling Zhou, Chunxia Zhao
Summary: Myeloid-derived suppressor cells (MDSCs) are immature and heterogeneous myeloid cells with immunosuppressive functions, and they play important roles in cancer, chronic inflammatory diseases, and autoimmune disorders. Tumor necrosis factor alpha (TNF-alpha) regulates the accumulation and activation of MDSCs. In this review, the roles of TNF-alpha in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs are summarized, and the potential therapeutic effects of TNF-alpha on these cells in tumor growth and inflammatory disorders are discussed.
Article
Biochemistry & Molecular Biology
Sri Jayanti, Rita Moretti, Claudio Tiribelli, Silvia Gazzin
Summary: This study investigated the neuroprotective effect of low concentrations of UCB in a PD model and found that UCB could effectively protect against the loss of dopaminergic neurons, with inflammation being the key factor in this protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Matthew M. Cousins, Emily Morris, Christopher Maurino, Theresa P. Devasia, David Karnak, Dipankar Ray, Neehar D. Parikh, Dawn Owen, Randall K. Ten Haken, Matthew J. Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Summary: This study investigated the impact of liver radiation therapy on liver function. The findings suggest that elevated plasma sTNFR1 levels are associated with liver injury after liver radiation, indicating that increased inflammatory cytokine activity is a predictor of radiation-induced liver dysfunction.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shuyue Wang, Xiaojie Shi, Jie Li, Qianping Huang, Qun Ji, Ying Yao, Tao Wang, Lili Liu, Min Ye, Yun Deng, Peixiang Ma, Hongtao Xu, Guang Yang
Summary: TNF-alpha inhibitors have been successful in treating autoimmune diseases, but current approved drugs are limited to biological macromolecules. This study utilizes a natural product-enriched DNA-encoded library to identify small molecules that interfere with the protein-protein interaction between TNF-alpha and its receptor. Kaempferol, a natural product identified in the library, not only interacts with TNF-alpha directly but also blocks its interaction with TNFR1, thereby attenuating TNF-alpha signaling. This research provides a promising starting point for the development of small molecule TNF-alpha inhibitors for clinical use.
Article
Immunology
Lin Feng, Yinan Ma
Summary: The consumption of a high-fat diet increases TNF-alpha levels in the spleen of rats, along with upregulation of TLR4 and NF-kappa B mRNAs and downregulation of alpha 7nAChR mRNA expression in splenic macrophages. Exercise intervention can counteract the detrimental effects of HFD on TNF-alpha levels in the spleen and prevent the abnormal expression of these genes in rat spleen macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Hua Mao, Aude Angelini, Shengyu Li, Guangyu Wang, Luge Li, Cam Patterson, Xinchun Pi, Liang Xie
Summary: The deficiency in CRAT and the activation of the bile acid synthesis pathway in cardiomyocytes can cause chronic inflammation and contribute to the progression of heart failure.
Article
Gastroenterology & Hepatology
Ji Won Han, Da In Kim, Hee Chul Nam, U. Im Chang, Jin Mo Yang, Do Seon Song
Summary: This study investigates the association between systemic inflammation and sarcopenia in liver cirrhosis. The results demonstrate that serum tumor necrosis factor-alpha (TNF-alpha) levels are elevated in liver cirrhosis rats and correlated with muscle weight and myofiber diameter. Furthermore, treatment with rifaximin reduces TNF-alpha levels and improves sarcopenia in liver cirrhosis. These findings suggest a potential therapeutic target for managing sarcopenia in liver cirrhosis patients.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenyu Chen
Summary: In this study, it was found that SNHG7 improves the osteogenic differentiation of hDPSCs by inhibiting miR-6512-3p expression in an inflammatory environment induced by 50 ng/mL TNF-alpha. This provides potential targets for the treatment of periodontitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Tomoaki Tsutsumi, Hiroshi Akiyama, Yosuke Demizu, Nahoko Uchiyama, Sayaka Masada, Genichiro Tsuji, Ryoko Arai, Yasuhiro Abe, Takashi Hakamatsuka, Ken-ichi Izutsu, Yukihiro Goda, Haruhiro Okuda
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2019)
Article
Pharmacology & Pharmacy
Ken-ichi Izutsu, Yasuhiro Abe, Hiroyuki Yoshida
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Sayaka Masada, Genichiro Tsuji, Ryoko Arai, Nahoko Uchiyama, Yosuke Demizu, Tomoaki Tsutsumi, Yasuhiro Abe, Hiroshi Akiyama, Takashi Hakamatsuka, Ken-ichi Izutsu, Yukihiro Goda, Haruhiro Okuda
SCIENTIFIC REPORTS
(2019)
Article
Pharmacology & Pharmacy
Hiroyuki Yoshida, Akiko Usui, Yasuhiro Abe, Yukihiro Goda, Ken-ichi Izutsu
Article
Chemistry, Medicinal
Hiroyuki Yoshida, Yasuhiro Abe, Naomi Tomita, Ken-ichi Izutsu
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Chemistry, Medicinal
Yasuhiro Abe, Eiichi Yamamoto, Hiroyuki Yoshida, Akiko Usui, Naomi Tomita, Hitomi Kanno, Sayaka Masada, Hidetomo Yokoo, Genichiro Tsuji, Nahoko Uchiyama, Takashi Hakamatsuka, Yosuke Demizu, Ken-ichi Izutsu, Yukihiro Goda, Haruhiro Okuda
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Hiroyuki Yoshida, Yasuhiro Abe, Akiko Usui, Ken-ichi Izutsu
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2020)
Article
Pharmacology & Pharmacy
Hiroyuki Yoshida, Keita Teruya, Yasuhiro Abe, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi, Ken-ichi Izutsu
Summary: This study used PIV and CFD techniques to investigate the impact of air bubbles on tablet dissolution in a flow-through cell system, finding that bubbles can alter local flow dynamics, affecting dissolution rates, and highlighting the importance of deaeration in dissolution studies.
Article
Pharmacology & Pharmacy
Aoi Sakamoto, Ken-ichi Izutsu, Hiroyuki Yoshida, Yasuhiro Abe, Daisuke Inoue, Kiyohiko Sugano
Summary: A new floating lid method was developed in this study for dissolution tests using bicarbonate buffer solutions, effectively preventing pH changes. The method showed potential applications in formulation development by evaluating dissolution profiles of pH-sensitive colonic delivery tablets.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hiroko Shibata, Yusuke Nomura, Tsuyoshi Kawakami, Eiichi Yamamoto, Daisuke Ando, Nahoko Uchiyama, Hiroko Tokumoto, Tatsuo Koide, Hideyuki Sakoda, Hiroyuki Yoshida, Yasuhiro Abe, Takashi Hakamatsuka, Yoshiaki Ikarashi, Yuji Haishima, Akiko Ishii-Watabe, Ken-Ichi Izutsu, Masamitsu Honma, Yukihiro Goda
Summary: Foreign particles were found in Moderna vaccine vials at a vaccination site in Japan, leading to a recall of the affected batches. Analysis indicated that the particles were stainless steel SUS 316L, which had already been administered to some individuals. Further examination with a digital microscope revealed smaller particles, suggesting more vials may have been affected.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Medicinal
Yuki Takechi-Haraya, Akiko Usui, Ken-ichi Izutsu, Yasuhiro Abe
Summary: This study presents a new technique utilizing atomic force microscopy (AFM) to characterize mRNA-lipid nanoparticles (mRNA-LNPs) in an aqueous medium. The AFM method allows for the immobilization of mRNA-LNPs on a glass substrate without corruption, providing detailed images of their spherical and bleb-like structures. Additionally, the AFM method reveals the presence of nanoparticles with a diameter < 60 nm that cannot be detected by other techniques. This method complements the development and quality assessment of polydisperse mRNA-LNPs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Kentaro Nishiyama, Hiroki Akiba, Satoshi Nagata, Kouhei Tsumoto, Haruhiko Kamada, Hiroaki Ohno
Summary: Proximity-induced chemical reactions are rapid and site-specific, taking advantage of high affinity and highly selective interactions with templates. A biepitopic antigen-templated chemical reaction (BATER) is proposed, where reactive functional groups are conjugated to two antibodies that interact with two epitopes of the same antigen to accelerate the reaction. Visualizing the progress of BATER using fluorogenic click chemistry allows for optimal antibody selection and linker design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Emiko Urano, Tomotaka Okamura, Chikako Ono, Shiori Ueno, Satoshi Nagata, Haruhiko Kamada, Mahoko Higuchi, Mugi Furukawa, Wataru Kamitani, Yoshiharu Matsuura, Yoshihiro Kawaoka, Yasuhiro Yasutomi
Summary: The study examined COVID-19 cynomolgus monkey models with underlying diseases, finding that elderly monkeys had higher levels and longer periods of viral RNA after SARS-CoV-2 infection. Pneumonia was confirmed in all monkeys by computed tomography images.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Ken-ichi Izutsu, Akiko Usui, Eiichi Yamamoto, Yasuhiro Abe, Hiroyuki Yoshida, Yukihiro Goda
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Chemistry, Medicinal
Ken-ichi Lzutsu, Yasuhiro Abe, Chikako Yomota, Hiroyuki Yoshid
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
