The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions

Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity

(2018) Julianne C. Barry et al.   CYTOKINE

Adiponectin: A potential therapeutic target for metabolic syndrome

(2018) Abhijit A. Ghadge et al.   CYTOKINE & GROWTH FACTOR REVIEWS

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

(2018) Xiao-Qing Xiong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals

(2018) Mahsa Naghizadeh et al.   NUTRITION RESEARCH

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-Targeted Therapeutics for Metabolic Disease

(2018) Kristin R. Peterson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

(2018) Marcelo Rogero et al.   Nutrients

Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses in Obese Males

(2018) Daniel C. de Souza et al.   Frontiers in Physiology

Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese

(2018) Abdelkrim Khadir et al.   Frontiers in Endocrinology

Unknown

(2018)   CYTOMETRY PART B-CLINICAL CYTOMETRY

Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial

(2017) Ivan Luiz Padilha Bonfante et al.   European Journal of Sport Science

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals

(2017) Mallenahally Kusha Vidya et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Short-Term Exercise Training Alters Leukocyte Chemokine Receptors in Obese Adults

(2017) JULIANNE C. BARRY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Expression of MYD88 in Adipose Tissue of Obese People: Is There Some Role in the Development of Metabolic Syndrome?

(2017) Ada M. Cuevas et al.   Metabolic Syndrome and Related Disorders

Macrophage functions in lean and obese adipose tissue

(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Weight loss achieved using an energy restriction diet with normal or higher dietary protein decreased the number of CD14 ++ CD16 + proinflammatory monocytes and plasma lipids and lipoproteins in middle-aged, overweight, and obese adults

(2017) Jung Eun Kim et al.   NUTRITION RESEARCH

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

(2017) David B. Bartlett et al.   Oxidative Medicine and Cellular Longevity

Impact of aerobic water running training on peripheral immune-endocrine markers of overweight-obese women

(2017) A. Colato et al.   SCIENCE & SPORTS

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

(2017) Saket Gupta et al.   Scientific Reports

CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons

(2017) Thomas Garton et al.   Translational Stroke Research

Effect of resistance training on muscular strength and indicators of abdominal adiposity, metabolic risk, and inflammation in postmenopausal women: controlled and randomized clinical trial of efficacy of training volume

(2016) Paulo Ricardo Prado Nunes et al.   AGE

Differences in metabolic biomarkers in the blood and gene expression profiles of peripheral blood mononuclear cells among normal weight, mildly obese and moderately obese subjects

(2016) Un Ju Jung et al.   BRITISH JOURNAL OF NUTRITION

The effect of insulin resistance and exercise on the percentage of CD16+monocyte subset in obese individuals

(2016) Mariana A. de Matos et al.   CELL BIOCHEMISTRY AND FUNCTION

Monocyte cell adhesion molecule receptors in nascent metabolic syndrome

(2016) Ishwarlal Jialal et al.   CLINICAL BIOCHEMISTRY

High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight–obese individuals

(2016) Gilson P. Dorneles et al.   CYTOKINE

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ

(2016) J. S. Ruffino et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

(2016) Asghar Abbasi et al.   Journal of Neuroinflammation

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research?

(2016) Jorming Goh et al.   Frontiers in Endocrinology

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

(2015) Michael J. Kraakman et al.   Cell Metabolism

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation

(2015) J. D. Otvos et al.   CLINICAL CHEMISTRY

Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system

(2015) Mark A. Barnes et al.   CYTOKINE

IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells

(2015) Masaaki Hashiguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation

(2015) Felix M. Wensveen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

(2015) Xiao-Jing Zhang et al.   HYPERTENSION

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

(2015) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

GlycA is a Novel Marker of Inflammation Among Non-Critically Ill Hospitalized Patients with Type 2 Diabetes

(2015) Kathleen Dungan et al.   INFLAMMATION

Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes

(2015) Emily Robinson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Acute effects of high- and low-intensity exercise bouts on leukocyte counts

(2015) Pedro Rogério Da Silva Neves et al.   Journal of Exercise Science & Fitness

Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus

(2015) Yuan Liu et al.   Journal of Physical Therapy Science

Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways

(2015) Paula Rodriguez-Miguelez et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men

(2015) DIEGO T. BRUNELLI et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

(2015) Elise Jeffery et al.   NATURE CELL BIOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

(2015) Fahrettin Haczeyni et al.   Obesity

Unknown

(2015)   Obesity Reviews

Design of evacuation strategies with crowd density feedback

(2015) Luyuan Qi et al.   Science China-Information Sciences

Molecular and epigenetic basis of macrophage polarized activation

(2015) Chiara Porta et al.   SEMINARS IN IMMUNOLOGY

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity

(2015) Rasheed Ahmad et al.   Diabetology & Metabolic Syndrome

Leukotriene B4 as a Potential Therapeutic Target for the Treatment of Metabolic Disorders

(2015) Luciano Ribeiro Filgueiras et al.   Frontiers in Immunology

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment

(2015) Andrea A. Hill et al.   Molecular Metabolism

Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects

(2014) Paula Rodriguez-Miguelez et al.   AGE

Circulating pathogen associated molecular pattern – Binding proteins and High Mobility Group Box protein 1 in nascent metabolic syndrome: Implications for cellular Toll-like receptor activity

(2014) I. Jialal et al.   ATHEROSCLEROSIS

The fractalkine/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity

(2014) Ágnes Polyák et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults

(2014) Melissa M. Markofski et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Effects of concurrent training on inflammatory markers and expression of CD4, CD8, and HLA-DR in overweight and obese adults

(2014) Alana Colato et al.   Journal of Exercise Science & Fitness

Effect of Exercise Intervention on Changes in Free Fatty Acid Levels and Metabolic Risk Factors in Stroke Patients

(2014) Dae-Young Kim et al.   Journal of Physical Therapy Science

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

The immunomodulating role of exercise in metabolic disease

(2014) Graeme I. Lancaster et al.   TRENDS IN IMMUNOLOGY

Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome

(2014) Yin Xueyao et al.   International Journal of Endocrinology

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?

(2014) Michael James Kraakman et al.   Frontiers in Immunology

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men

(2013) Pernille Auerbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Immunological Goings-on in Visceral Adipose Tissue

(2013) Diane Mathis   Cell Metabolism

Impact of Physical Activity, Cardiorespiratory Fitness, and Exercise Training on Markers of Inflammation

(2013) Carl J. Lavie et al.   Journal of Cardiopulmonary Rehabilitation and Prevention

Adipose Tissue Foam Cells Are Present in Human Obesity

(2013) Hagit Shapiro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective

(2013) Ishwarlal Jialal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Negative regulation of human mononuclear phagocyte function

(2013) M Hedl et al.   Mucosal Immunology

Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats

(2013) Alexandre G. Oliveira et al.   Obesity

Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans

(2013) T. Pecht et al.   Obesity Reviews

White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study

(2013) Nancy Babio et al.   PLoS One

Soluble CD14 Levels Reflect Liver Inflammation in Patients with Nonalcoholic Steatohepatitis

(2013) Yuji Ogawa et al.   PLoS One

Effects of Exercise Training on Chronic Inflammation in Obesity

(2013) Tongjian You et al.   SPORTS MEDICINE

Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects

(2013) Sara M. Reyna et al.   Journal of Diabetes Research

In situ production of innate immune cells in murine white adipose tissue

(2012) S. Poglio et al.   BLOOD

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

(2012) I. Jialal et al.   DIABETES CARE

Obesity is associated with activated and insulin resistant immune cells

(2012) A. Viardot et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Association between the human immune response and body mass index

(2012) Silvia Ilavská et al.   HUMAN IMMUNOLOGY

Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males

(2012) Melanie Leggate et al.   JOURNAL OF APPLIED PHYSIOLOGY

Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation

(2012) FangFang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation

(2012) Rasheed Ahmad et al.   Journal of Inflammation-London

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R

(2012) Xiaolei Ma et al.   STRUCTURE

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Relation of depot-specific adipose inflammation to insulin resistance in human obesity

(2012) S J Bigornia et al.   Nutrition & Diabetes

Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms

(2012) Ling Yang et al.   Frontiers in Physiology

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

CD14 Modulates Inflammation-Driven Insulin Resistance

(2011) J. M. Fernandez-Real et al.   DIABETES

Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats

(2011) Alexandre G. Oliveira et al.   DIABETES

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

(2011) R. Shah et al.   DIABETES

Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects

(2011) Gael Bories et al.   Diabetes & Vascular Disease Research

Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro

(2011) Elham M. Youssef-Elabd et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice

(2011) Seung-Jin Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Monocyte and T-Cell Responses to Exercise Training in Elderly Subjects

(2011) Kazuhiro Shimizu et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice

(2009) Victoria J. Vieira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Unbalanced M1/M2 Phenotype of Peripheral Blood Monocytes in Obese Diabetic Patients: Effect of pioglitazone

(2009) N. Satoh et al.   DIABETES CARE

Monocyte heterogeneity in obesity and subclinical atherosclerosis

(2009) K. S. Rogacev et al.   EUROPEAN HEART JOURNAL

Adiponectin Inhibits Pro-inflammatory Signaling in Human Macrophages Independent of Interleukin-10

(2009) Eduardo J. Folco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss

(2009) S. Balducci et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass

(2008) Anders Rinnov Nielsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

(2008) Andréa M Caricilli et al.   JOURNAL OF ENDOCRINOLOGY

Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?

(2008) Kyle L. Timmerman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in Atherogenesis

(2007) Yoshihisa Okamoto et al.   CIRCULATION RESEARCH