Negative regulation of human mononuclear phagocyte function

Inhibitory ITAM Signaling by Fc RI-FcR  Chain Controls Multiple Activating Responses and Prevents Renal Inflammation

(2014) Y. Kanamaru et al.   JOURNAL OF IMMUNOLOGY

Signaling Mechanism of HIV-1 gp120 and Virion-Induced IL-1  Release in Primary Human Macrophages

(2014) R. Cheung et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

SOCS1 Regulates the IFN but Not NF B Pathway in TLR-Stimulated Human Monocytes and Macrophages

(2014) C. M. Prele et al.   JOURNAL OF IMMUNOLOGY

Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice

(2012) Ranyia Matta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Vitamin D: New Roles and Therapeutic Potential in Inflammatory Bowel Disease

(2012) Tara Raftery et al.   CURRENT DRUG METABOLISM

Nod2-Induced Autocrine Interleukin-1 Alters Signaling by ERK and p38 to Differentially Regulate Secretion of Inflammatory Cytokines

(2012) Matija Hedl et al.   GASTROENTEROLOGY

Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments

(2012) Y Huang et al.   GENES AND IMMUNITY

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene

(2012) S E Löfgren et al.   GENES AND IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Interleukin-10 Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Translation through a SHIP1-dependent Pathway

(2012) Catherine S. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10 Regulates Il12b Expression via Histone Deacetylation: Implications for Intestinal Macrophage Homeostasis

(2012) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production

(2012) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Human TOLLIP Regulates TLR2 and TLR4 Signaling and Its Polymorphisms Are Associated with Susceptibility to Tuberculosis

(2012) J. A. Shah et al.   JOURNAL OF IMMUNOLOGY

IRF5 Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells

(2012) M. Hedl et al.   JOURNAL OF IMMUNOLOGY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated With Susceptibility to Tuberculosis

(2012) David J. Horne et al.   JOURNAL OF INFECTIOUS DISEASES

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

(2012) F A Carvalho et al.   Mucosal Immunology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

(2012) Shu Zhu et al.   NATURE MEDICINE

Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice

(2012) Irving C. Allen et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNAs and related polymorphisms in rheumatoid arthritis susceptibility

(2011) Anthoula Chatzikyriakidou et al.   AUTOIMMUNITY REVIEWS

Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases: Figure 1

(2011) Alexander J.P. Edwards et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen

(2011) T. L. McGaha et al.   BLOOD

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

(2011) Reena Rani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLE1 Modifies the Effects of NOD2 in the Pathogenesis of Crohn's Disease

(2011) Elaine R. Nimmo et al.   GASTROENTEROLOGY

Stromal Regulation of Human Gastric Dendritic Cells Restricts the Th1 Response to Helicobacter pylori

(2011) Diane Bimczok et al.   GASTROENTEROLOGY

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease

(2011) Ashwin N. Ananthakrishnan et al.   GASTROENTEROLOGY

Intestinal expression of SHIP in inflammatory bowel diseases

(2011) Ingrid Arijs et al.   GUT

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering

(2011) Sonia Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages

(2011) Matija Hedl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling

(2011) Linlin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

(2011) Oscar Medina-Contreras et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro differentiation of human macrophages with enhanced antimycobacterial activity

(2011) Guillaume Vogt et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

(2011) Sambit K. Nanda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11

(2011) A. Waddell et al.   JOURNAL OF IMMUNOLOGY

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

(2011) O. M. Pena et al.   JOURNAL OF IMMUNOLOGY

A SOCS-1 Promoter Variant Is Associated with Total Serum IgE Levels

(2011) J. Mostecki et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

Mucosal Macrophages in Intestinal Homeostasis and Inflammation

(2011) Allan McI Mowat et al.   Journal of Innate Immunity

Vitamin D Deficiency in Patients With Inflammatory Bowel Disease

(2011) Alex Ulitsky et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

The NFKB1 (g.-24519delATTG) Variant is Associated with Necrotizing Enterocolitis (NEC) in Premature Infants

(2011) Venkatesh Sampath et al.   JOURNAL OF SURGICAL RESEARCH

Unknown

(2011) Jelena Vojinovic et al.   MOLECULAR MEDICINE

Unknown

(2011) Charles Dinarello et al.   MOLECULAR MEDICINE

A role for interleukin-33 in TH2-polarized intestinal inflammation?

(2011) J B Seidelin et al.   Mucosal Immunology

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Tumor necrosis factor induces GSK3 kinase–mediated cross-tolerance to endotoxin in macrophages

(2011) Sung Ho Park et al.   NATURE IMMUNOLOGY

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b

(2011) Riccardo L Rossi et al.   NATURE IMMUNOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

The Mechanism of Excessive Intestinal Inflammation in Necrotizing Enterocolitis: An Immature Innate Immune Response

(2011) Nanda Nanthakumar et al.   PLoS One

A20-binding inhibitor of NF- B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein   activation and protects from inflammatory disease

(2011) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of p38 and MKP-1 in Response to NOD1/TLR4 Stimulation in Sarcoid Bronchoalveolar Cells

(2010) Ruchi Rastogi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis

(2010) P. Dieude et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation

(2010) S. Borghini et al.   ARTHRITIS AND RHEUMATISM

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

Autoinflammatory Disease Reloaded: A Clinical Perspective

(2010) Daniel L. Kastner et al.   CELL

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

IRAK1 functional genetic variant affects severity of septic shock*

(2010) Julie Toubiana et al.   CRITICAL CARE MEDICINE

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine

(2010) Amlan Biswas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

(2010) Meaghan M. Hunter et al.   GASTROENTEROLOGY

Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ

(2010) Jennifer K. Uno et al.   GASTROENTEROLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

(2010) Matija Hedl et al.   GASTROENTEROLOGY

TGF-β2 Suppresses Macrophage Cytokine Production and Mucosal Inflammatory Responses in the Developing Intestine

(2010) Akhil Maheshwari et al.   GASTROENTEROLOGY

SHIP deficiency causes Crohn's disease-like ileitis

(2010) W. G. Kerr et al.   GUT

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohnʼs disease

(2010) Peter Laszlo Lakatos et al.   INFLAMMATORY BOWEL DISEASES

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

(2010) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Role for interferon regulatory factors in autoimmunity

(2010) Christophe Richez et al.   JOINT BONE SPINE

Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms

(2010) Jon R. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation Anergy in Human Intestinal Macrophages Is Due to Smad-induced IκBα Expression and NF-κB Inactivation

(2010) Lesley E. Smythies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clcn5 Knockout Mice Exhibit Novel Immunomodulatory Effects and Are More Susceptible to Dextran Sulfate Sodium-Induced Colitis

(2010) P. Alex et al.   JOURNAL OF IMMUNOLOGY

A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E2-Induced Immunosuppression Post-Bone Marrow Transplantation

(2010) L. L. N. Hubbard et al.   JOURNAL OF IMMUNOLOGY

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

(2010) Joan Ní Gabhann et al.   JOURNAL OF IMMUNOLOGY

An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation

(2010) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

Infant colitis—it's in the genes

(2010) Erik-Oliver Glocker et al.   LANCET

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF- B Activation in Macrophages

(2010) B. Chaurasia et al.   MOLECULAR AND CELLULAR BIOLOGY

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

(2010) Luca Pastorelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

(2010) R. Rodriguez-Manzanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Enhanced Expression of Single Immunoglobulin IL-1 Receptor-Related Molecule Ameliorates LPS-Induced Acute Lung Injury in Mice

(2010) XuXin Chen et al.   SHOCK

Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome

(2009) Liying Yang et al.   GASTROENTEROLOGY

Phosphatidylinositol 3-Kinase γ Inhibition Ameliorates Inflammation and Tumor Growth in a Model of Colitis-Associated Cancer

(2009) Ana González–García et al.   GASTROENTEROLOGY

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis

(2009) Betsy C. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice

(2009) W. J. Frazier et al.   JOURNAL OF IMMUNOLOGY

Human CD14+ Macrophages in Intestinal Lamina Propria Exhibit Potent Antigen-Presenting Ability

(2009) N. Kamada et al.   JOURNAL OF IMMUNOLOGY

Critical Role of IL-1 Receptor-Associated Kinase-M in Regulating Chemokine-Dependent Deleterious Inflammation in Murine Influenza Pneumonia

(2009) M. Seki et al.   JOURNAL OF IMMUNOLOGY

Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients

(2009) Carlos del Fresno et al.   JOURNAL OF IMMUNOLOGY

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering

(2009) A.-C. Raby et al.   JOURNAL OF IMMUNOLOGY

Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity

(2009) A. S. Almeida et al.   JOURNAL OF IMMUNOLOGY

Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses

(2009) J. S. Adams et al.   JOURNAL OF IMMUNOLOGY

Survival and Migration of Human Dendritic Cells Are Regulated by an IFN- -Inducible Axl/Gas6 Pathway

(2009) S. Scutera et al.   JOURNAL OF IMMUNOLOGY

Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance

(2009) M. E. Gazzar et al.   MOLECULAR AND CELLULAR BIOLOGY

Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

(2009) I D Iliev et al.   Mucosal Immunology

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

(2009) Vladimir Litvak et al.   NATURE IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells

(2009) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization

(2009) Cecilia Garlanda et al.   TRENDS IN IMMUNOLOGY

Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis

(2008) Mark M. Wurfel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α

(2008) Feng Wu et al.   GASTROENTEROLOGY

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

A Prescription for Human Immunology

(2008) Mark M. Davis   IMMUNITY

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway

(2008) Takahito Sanada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoregulation of Th1-mediated inflammation bytwist1

(2008) Uwe Niesner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

(2008) Maciej Lech et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate immune recognition of the indigenous microbial flora

(2008) S Rakoff-Nahoum et al.   Mucosal Immunology

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Mutations in NALP12 cause hereditary periodic fever syndromes

(2008) I. Jeru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX

Twist-2 Controls Myeloid Lineage Development and Function

(2008) Andrew B Sharabi et al.   PLOS BIOLOGY