Article
Public, Environmental & Occupational Health
Yukun Hu, Yong Zhang, XiaoYa Qi, XiaoYang Xu, Jamal Rahmani, Ruixue Bai, Ying Mei
Summary: Wearable physical activity trackers are gaining popularity for weight management, but there is limited evidence of their effectiveness. Studies have shown that supervised exercise is better than unsupervised exercise, but there is no evidence comparing remote supervision exercise with self-directed exercise based on mHealth. This study compared the effects of mHealth-based supervised exercise to mHealth-based self-directed exercise on weight control in overweight and obese individuals. The results showed that supervised exercise was more effective in improving health factors compared to self-directed exercise.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Roberto Pippi, Matteo Vandoni, Matteo Tortorella, Vittorio Bini, Carmine Giuseppe Fanelli
Summary: In recent years, there has been a study on the effects of a water-based exercise program in overweight/obese people with or without type 2 diabetes. The results showed improvements in body mass index, waist circumference, and blood pressure. This type of exercise intervention supervised by graduates in sports sciences is beneficial for patients with metabolic diseases, especially those with other health impairments.
Article
Nutrition & Dietetics
Miriam Oros, Julia Siscart, Daniel Perejon, Maria Catalina Serna, Pere Godoy, Blanca Salinas-Roca
Summary: This study examines the prevalence of overweight and obesity in pregnant women from different ethnic groups and investigates the associated comorbidities. The results show an increasing trend in obesity among pregnant women, with a higher incidence of overweight and obesity in certain ethnic groups. High body mass index (BMI) is found to be associated with hypertension, gestational diabetes mellitus, and depression.
Review
Medicine, General & Internal
Jun Kuang, Suwen Sun, Fengmei Ke
Summary: The meta-analysis findings suggest that exercise therapy for obese or overweight pregnant women can reduce the incidence of gestational diabetes and macrosomia rates, as well as control weight gain during pregnancy.
Review
Medicine, General & Internal
Carlos Pascual-Morena, Ivan Cavero-Redondo, Celia alvarez-Bueno, Jose Alberto Martinez-Hortelano, Sara Reina-Gutierrez, Alicia Saz-Lara, Sergio Nunez de Arenas-Arroyo, Vicente Martinez-Vizcaino
Summary: The study found that combined exercise can reduce the risk of macrosomia in pregnant women with overweight/obesity, while metformin can reduce the risk of cesarean section in pregnant women with obesity. However, there is evidence suggesting a larger effect of physical exercise in other outcomes for this population group.
FRONTIERS IN MEDICINE
(2021)
Review
Endocrinology & Metabolism
Maria Porflitt-Rodriguez, Valentina Guzman-Arriagada, Romina Sandoval-Valderrama, Charmaine S. Tam, Francisca Pavicic, Pamela Ehrenfeld, Sergio Martinez-Huenchullan
Summary: This article systematically reviewed the effects of aerobic exercise on FGF21 in overweight and obese individuals. It found that acute exercise tends to increase circulating levels of FGF21, while chronic exercise programs have the opposite effect and induce increases in FGF receptors and beta-klotho in adipose tissue, liver, and skeletal muscle.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Immunology
Therese Bredholt Onyango, Fan Zhou, Geir Bredholt, Karl A. Brokstad, Sarah Lartey, Kristin G. -I. Mohn, Turkuler Ozgumus, Bard Reiakvam Kittang, Dagrun Waag Linchausen, Shahin Shafiani, Rebecca Elyanow, Bjorn Blomberg, Nina Langeland, Rebecca Jane Cox
Summary: Obesity and overweight are associated with enhanced immune responses and increased disease severity after SARS-CoV-2 infection. This study found that overweight and obese patients had stronger immune responses after infection, and these responses were correlated with BMI, age, and disease severity. Additionally, overweight and obese patients had a higher proportion of unique SARS-CoV-2 specific T cell clones after infection. However, regardless of weight, COVID-19 vaccination can boost immune responses in all patients, although a stronger immune response was observed in normal weight patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Physiology
Anamei Silva-Reis, Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Thiago Gibson Goncalves-Alves, Victor Hugo Souza-Palmeira, Helida Cristina Aquino-Santos, Andre Luis Lacerda Bachi, Luis Vicente Franco de Oliveira, Rodrigo Alvaro Brandao Lopes-Martins, Iranse Oliveira-Silva, Regiane Albertini, Claudio Ricardo Frison, Rodolfo P. Vieira
Summary: This study investigated the effects of combined physical exercise on lung function and immune response in non-obese, overweight, and obese grade I women. The results showed that combined physical exercise improved lung function and mechanics in obese grade I women and reduced pro-fibrotic IGF-1 levels while increasing anti-fibrotic Klotho levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Carlos Pascual-Morena, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Maribel Luceron-Lucas-Torres, Gema Sanabria-Martinez, Raquel Poyatos-Leon, Beatriz Rodriguez-Martin, Vicente Martinez-Vizcaino
Summary: The study suggests that aerobic exercise may have the greatest effect in reducing the risk of gestational diabetes mellitus (GDM) and perhaps maternal weight gain (MWG). However, no intervention showed any effect on the reduction of hypertensive disorders of pregnancy (HDP).
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Physiology
Thomasina Donovan, Amanda L. Bain, Wenjuan Tu, David B. Pyne, Sudha Rao
Summary: Exercise can limit the accumulation of exhausted and senescent CD8(+) T cells by promoting apoptosis in the peripheral blood compartment. Further research is needed to determine the clinical relevance of this effect in cancer prevention and vaccine efficacy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Erik D. Hanson, Lauren C. Bates, Elizabeth P. Harrell, David B. Bartlett, Jordan T. Lee, Chad W. Wagoner, Mohamdod S. Alzer, Dean J. Amatuli, Brian C. Jensen, Allison M. Deal, Hyman B. Muss, Kirsten A. Nyrop, Claudio L. Battaglini
Summary: Exercise may attenuate immunosenescence and improve immune cell response in older breast cancer survivors, although deficits in certain cell types like MAIT and CD3(+) are observed at baseline. Acute exercise leads to mobilization of immune cells, with trends towards improvement in BCS post-exercise, suggesting potential benefits of exercise training in rescuing immune dysfunction associated with aging and cancer.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Nutrition & Dietetics
Izabela Chudzicka-Strugala, Iwona Golebiewska, Beata Banaszewska, Grzegorz Brudecki, Barbara Zwozdziak
Summary: PCOS is a common endocrine and metabolic disorder in premenopausal women, closely related to diet and lifestyle. Obesity is linked to PCOS, with abdominal obesity contributing to inflammatory changes. Improving diet, weight loss, and probiotic intake play important roles in managing PCOS patients.
Review
Nutrition & Dietetics
Anna A. Wawer, Nicolette A. Hodyl, Susan Fairweather-Tait, Bernd Froessler
Summary: Low-grade inflammation often present in individuals with obesity can affect iron uptake and metabolism, increasing the risk of iron deficiency and iron-deficiency anemia. Pregnant women are particularly vulnerable to these risks. Therefore, closer monitoring of iron status and weight gain is recommended for pregnant women living with obesity.
Review
Immunology
Xiaoqing Chen, Xue Liu, Yichao Jiang, Ningshao Xia, Chao Liu, Wenxin Luo
Summary: Chronic hepatitis B virus (HBV) infection is a major public health challenge, with over 250 million people worldwide infected. Priming of naive HBV-specific CD8 T cells is hindered, and this is closely related to abnormalities in the complex immune microenvironment. In this article, we summarize recent progress in understanding the abnormal priming of HBV-specific CD8 T cells and discuss corresponding immunotherapies to facilitate their functional recovery. We also highlight the importance of balancing viral clearance and pathological liver injury induced by CD8 T-cell activation during drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Megan Rodgers, Alexandra L. Migdal, Tahereh Ghorbani Rodriguez, Zsu-Zsu Chen, Anjali K. Nath, Robert E. Gerszten, Natasha Kasid, Elena Toschi, Juliet Tripaldi, Brent Heineman, Minh Phan, Long Ngo, Eleftheria Maratos-Flier, Jody Dushay
Summary: In this study, long-term weight loss with exenatide treatment was similar to that achieved with a hypocaloric diet in a population of early high responders. Weight loss at 3 months of treatment predicted super responder status in both treatment groups, with individual variability observed in weight loss outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Maria Isabel Fuhro, Francini P. Andrade, Gilson P. Dorneles, Fabio S. Lira, Pedro R. T. Romao, Alessandra Peres, Mariane Monteiro
Summary: Intradialytic exercise had no significant impact on CCR5 expression in CKD patients, but could prevent excessive inflammatory response induced by hemodialysis in elderly patients with CKD.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Engineering, Environmental
Roseana Boek Carvalho, Bruna Marmett, Gilson Pires Dorneles, Igor Martins da Silva, Pedro Roosevelt Torres Romao, Flavio Manoel Rodrigues da Silva Junior, Claudia Ramos Rhoden
Summary: The study evaluated the health risk of exposure to low, mean, and high concentrations of ozone during different durations of exercise in the city of Rio Grande, southern Brazil. The findings showed that as the concentration of ozone and the duration of exposure increase, the health risk also increases.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Gastroenterology & Hepatology
Mary J. Soares Goncalves Velasque, Gisele Branchini, Anderson Catarina, Lais Bettoni, Renata S. Fernandes, Arthur Ferreira Da Silva, Gilson P. Dorneles, Igor Martins da Silva, Maeli A. Santos, Juliana Sumienski, Alessandra Peres, Adriana Roehe, Maria B. da Fonte Kohek, Marilene Porawski, Fernanda B. Nunes
Summary: This study aimed to evaluate the effects of treatment with fish oil rich in w3 on liver changes and damage resulting from experimental sepsis. The results suggest that w3 has an antioxidant effect, alleviating liver injury and dysfunction.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2023)
Article
Biodiversity Conservation
Joel Henrique Ellwanger, Evelise Bach, Nicolas Felipe Drumm Muller, Jader da Cruz Cardoso, Guilherme Dubal dos Santos Seger, Jose Artur Bogo Chies
Summary: This study investigated the diversity of mosquitoes in the Porto Alegre region of Brazil and explored the landscape features that may affect their species richness and composition. The study found that the percentage coverage of temporary crops and the Simpson's diversity index at the landscape level were possible variables explaining species richness, while the percentage coverage of urban and temporary crops were the best predictors of species composition. The study highlights the importance of green urban areas for biodiversity conservation and provides valuable data for entomological surveillance programs in Brazil.
JOURNAL OF INSECT CONSERVATION
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Kniphoff da Silva Lawisch, Vanderlei Biolchi, Gabriela Kaufmann, Gabriela Nicolai, Eduarda Capitaneo, Thais Regina Rosembach, Janaina Zang, Ilma Simoni Brum, Jose Artur Bogo Chies
Summary: This study investigated the association of FASL, BCL-2, and BAX gene polymorphisms with prostate cancer (PCA) and benign prostatic hyperplasia (BPH) in Southern Brazilian patients. The findings suggest that the FASL CC genotype may be a risk factor for PCA, while the BCL-2 CC genotype may act as a protective factor.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Psychology, Biological
Patricia Paula Bazzanello Henrique, Fabrizzio Martin Pelle Perez, Gilson Dorneles, Alessandra Peres, Arthiese Korb, Viviane Elsner, Ana Carolina Bertoletti De Marchi
Summary: The study aimed to evaluate the acute and long-term impact of exergaming and conventional therapy on brain-derived neurotrophic factor, inflammatory markers, and epigenetic mechanisms in healthy elderly women. The interventions improved cognitive performance, inflammatory profile, BDNF levels, and induced histone acetylation in elderly women.
PHYSIOLOGY & BEHAVIOR
(2023)
Review
Virology
Joel Henrique Ellwanger, Bruna Kulmann-Leal, Marina Ziliotto, Jose Artur Bogo Chies
Summary: Genome integrity is crucial for cell functioning, and chromosome instability from factors like replication stress, pollution, and viral infections can lead to age-related diseases. Limited information exists on how viral infections affect micronucleus formation and other chromosomal aberrations. HIV infection can directly cause chromosome instability through interactions with host DNA and indirectly through chronic inflammation or ART use. This article reviews studies on genomic instability in HIV infection, discussing its connections with immunosenescence and age-related diseases. Monitoring HIV-infected individuals should consider the increased risk of chromosome instability, and interventions like reducing genotoxin exposure and antioxidant-rich diets should be considered. Therapies targeting chronic inflammation in HIV infection are needed.
Review
Green & Sustainable Science & Technology
Joel Henrique Ellwanger, Carlos Afonso Nobre, Jose Artur Bogo Chies
Summary: Brazil is one of the most biodiverse countries in the world, but its biodiversity potential remains untapped. To change this, Brazil needs to recognize and harness the power of its biodiversity, focusing on industry, science and technology, biological conservation, ecosystem maintenance, ecotourism, and sustainable development of local populations. Joint action from the Brazilian population and scientific community is crucial, along with the election of politicians committed to sustainable development and increased research and technology based on Brazilian biodiversity. The article also highlights other reasons for preserving Brazilian biodiversity, such as intrinsic, cultural, and ethical values. Finally, it argues for Brazil to reclaim its global leadership in the environmental agenda and leverage its biological diversity as a source of Soft Power and sustainable bio-based economy.
Article
Genetics & Heredity
Gilson P. Dorneles, Paula C. Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Junior, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: Higher levels of endotoxin and systemic inflammatory markers were found in severe COVID-19 patients compared to healthy controls and mild COVID-19 patients. Severe COVID-19 patients also exhibited higher levels of inflammatory cytokines and altered monocyte populations. The response to endotoxin stimulation differed between severe COVID-19 patients and controls, with lower cytokine production but higher levels of PGE-2.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Organic
Paulo Cesar Santana Filho, Matheus Brasil da Silva, Bruna Nathalia Malaquias da Silva, Tiago Fazolo, Gilson Pires Dorneles, Juliano Braun de Azeredo, Mario Alf da Rosa, Luiz Carlos Rodrigues Junior, Alessandra Peres, Romulo Faria Santos Canto, Pedro Roosevelt Torres Romao
Summary: In this study, a series of seleno-indoles were designed and synthesized, and their activity against Leishmania amazonensis promastigotes and amastigotes was investigated. The most promising seleno-indoles 2a, 2c, 2f, 2g, and 3a exhibited good activity against L. amazonensis and showed low toxicity to mammalian cells, indicating their potential as drug candidates for further research.
Review
Multidisciplinary Sciences
Valeria de Lima Kaminski, Rafael Tomoya Michita, Joel Henrique Ellwanger, Tiago Degani Veit, Jaqueline Bohrer Schuch, Rudimar dos Santos Riesgo, Tatiana Roman, Jose Artur Bogo Chies
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects behavioral and social skills, with a dramatic increase in incidence worldwide. Genetic, environmental, and immune-related factors, including maternal immune activation (MIA) and alterations in extracellular vesicles (EVs), are believed to be involved in ASD development. This article discusses the potential roles of EVs in MIA, along with various other factors, in the etiology of ASD.
Article
Genetics & Heredity
Julio Daimar Oliveira Correa, Francis Maria Bao Zambra, Rafael Tomoya Michita, Mario Reis Alvares-da-Silva, Daniel Simon, Jose Artur Bogo Chies
Summary: HCV infection is a major cause of chronic liver disease and can lead to fibrosis, cirrhosis and hepatocellular carcinoma. Variations in the HLA-G gene may affect susceptibility to HCV infection and the development of related liver diseases.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2023)
Article
Endocrinology & Metabolism
Lucas Ribeiro da Silva, Giuseppe Potrick Stefani, Gilson Pires Dorneles, Aline Marcadenti, Pedro Dal Lago
Summary: The aim of this study was to compare the effects of high carbohydrate and high-fat meals on substrate oxidation during an exercise incremental test. Ten untrained male subjects underwent two days of testing, with each day consisting of either a high carbohydrate meal or a high-fat meal. The high-fat meal led to increased fat oxidation and decreased respiratory exchange ratio compared to the high carbohydrate meal during the exercise. However, there were no significant differences in the maximum oxidation point of substrates, oxidation rate over time, and heart rate between the two meals.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Genetics & Heredity
Juliana da Silveira Schauren, Amanda Henrique de Oliveira, Camila Rosat Consiglio, Odirlei Andre Monticielo, Ricardo Machado Xavier, Natalia Schneider Nunes, Joel Henrique Ellwanger, Jose Artur Bogo Chies
Summary: This study investigated the impact of CCR5 promoter region polymorphisms on the development of systemic lupus erythematosus (SLE) and found that CCR5 Delta 32 polymorphism confers protection against the disease in European-derived patients and susceptibility to class IV nephritis in African-derived patients.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2023)
Article
Multidisciplinary Sciences
Juliano Andre Boquett, Fernanda S. L. Vianna, Nelson J. R. Fagundes, Lucas Schroeder, Marcia Barbian, Marcelo Zagonel-Oliveira, Tiago F. Andreis, Luis Cristovao M. S. Porto, Jose Artur B. Chies, Lavinia Schuler-Faccini, Patricia Ashton-Prolla, Clevia Rosset
Summary: This study investigated the correlation between HLA haplotypes and regional distribution of COVID-19 mortality rates in Brazil. The results showed a positive association between the HLA-A*01-B*08-DRB1*03 haplotype and COVID-19 mortality rates, suggesting it as an additional risk factor for COVID-19 deaths. The findings highlight the impact of HLA genes on COVID-19 outcomes in different populations.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
