Article
Biochemistry & Molecular Biology
Vicente Barrios, Santiago Guerra-Cantera, Alvaro Martin-Rivada, Sandra Canelles, Ana Campillo-Calatayud, Eduardo Arilla-Ferreiro, Laura M. Frago, Julie A. Chowen, Jesus Argente
Summary: Leptin is involved in regulating insulin signaling and lipid metabolism in peripheral tissues. This study found that leptin activates insulin signaling and reduces muscle inflammation parameters, while decreasing the levels of non-esterified fatty acids.
Article
Immunology
Xiaogao Jin, Yanlin Wang
Summary: The study revealed that globular adiponectin induced the production of inflammatory cytokines in Raw 264.7 cells, while full-length adiponectin promoted macrophage migration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qi Guo, Shicheng Cao, Xiaohong Wang
Summary: Exercise can improve the pathogenic changes in adiponectin and betatrophin levels in insulin-resistant mice. This effect is achieved by increasing adiponectin levels and reducing betatrophin levels through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Weifen Li, Tahir Ali, Chengyou Zheng, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Ningning Li, Zhi-Jian Yu, Shupeng Li
Summary: Research suggests that adiponectin deprivation may enhance antidepressive-like behaviors in a depression model, and changes in adiponectin receptors and IBA-1 in antidepressive responses may be associated with dysregulated neuroinflammatory status and BDNF signaling.
MOLECULAR PSYCHIATRY
(2022)
Review
Geriatrics & Gerontology
Mousa Khalafi, Abbas Malandish, Sara K. Rosenkranz
Summary: The systematic review and meta-analysis found that exercise training significantly reduced IL-6, TNF-alpha, and CRP, while increasing adiponectin in postmenopausal women. Subgroup analyses also showed that different types of training (aerobic, resistance, combined) had significant effects on inflammatory markers, and the benefits were seen in both younger and older participants. These results suggest that exercise training may be an effective intervention for reducing inflammation and increasing adiponectin in postmenopausal women.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peixin Sun, Lianne M. S. Bouwman, Jo-lene de Deugd, Inge van der Stelt, Annemarie Oosting, Jaap Keijer, Evert M. van Schothorst
Summary: Short-term post-weaning nutrition may have long-lasting effects, but in this study, partial replacement of glucose by galactose in the diet did not affect body weight, body composition, and insulin sensitivity in adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Debrup Chakraborty, Wei Jin, Jing Wang
Summary: Adiponectin is closely associated with metabolism and cancer, with low levels reported in obesity, inflammatory diseases, and various cancers including colorectal cancer. However, the exact function and mechanisms of adiponectin in colorectal cancer remain unclear, with contradictory reports on its role in cancer. Further research is needed to better understand adiponectin's function in tumor development.
Article
Cell Biology
Ruben Garcia-Martin, Bruna Brasil Brandao, Thomas Thomou, Emrah Altindis, C. Ronald Kahn
Summary: Exosomes/small extracellular vesicles (sEVs) can mediate cell-to-cell communication through their miRNA and protein cargo. Each cell type has a unique sEV proteome, but there are also common markers. Specific markers of different cell types can predict the tissue of origin of serum sEVs, as demonstrated in a mouse model.
Article
Medicine, General & Internal
Yelizavet D. Lomakova, Xinhua Chen, T. Peter Stein, Robert A. Steer
Summary: This study investigated the relationship between adiponectin levels and preterm delivery in a multi-ethnic group. The results showed that African American women had lower adiponectin levels and higher preterm delivery rates compared to Hispanic and Caucasian women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Sydney Song, Lindsey N. Druschel, E. Ricky Chan, Jeffrey R. Capadona
Summary: Brain-Machine Interface systems (BMIs) are valuable devices that provide functional restoration for patients with spinal cord injury and improved integration for patients requiring prostheses. However, the recording performance of intracortical microelectrodes used in BMIs tends to decline over time due to the neuroinflammatory response and the formation of a glial scar. Traditional methods of studying neuroinflammation have focused on a limited number of cellular and protein markers, but recent advancements in gene expression analysis have allowed researchers to identify chronic molecular players at the electrode-tissue interface. In this study, the gene expression at the interface of nonfunctioning probes implanted in mice was investigated, and 28 differentially expressed genes were found, many of which were involved in the complement and extracellular matrix system. These genes could serve as potential therapeutic targets for improving the long-term integration of microelectrodes.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Ye Jian, Shunling Yuan, Jialun Yang, Yong Lei, Xuan Li, Wenfeng Liu
Summary: Abnormalities in autophagy are associated with Alzheimer's disease, and exercise can improve this condition by activating the AdipoR1/AMPK/TFEB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zihang Liu, Panpan Deng, Shengnan Liu, Yiying Bian, Yuanyuan Xu, Qiang Zhang, Huihui Wang, Jingbo Pi
Summary: Cytokine storm refers to a state of the immune system characterized by excessive release of cytokines, leading to inflammation, organ failure, and disease outcomes. NRF2, a transcription factor involved in cellular redox homeostasis, has emerged as a potential therapeutic target in preventing and treating cytokine storms. This review summarizes the causes of cytokine storms and the rationale for targeting NRF2 as a therapeutic intervention.
Review
Physiology
Hyun-Kyung So, Sunghee Kim, Jong-Sun Kang, Sang-Jin Lee
Summary: Arginine methylation mediated by PRMTs plays a crucial role in skeletal muscle physiology and pathophysiology, particularly in its relationship with inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marina Ruxandra Otelea, Oana Cristina Arghir, Corina Zugravu, Agripina Rascu
Summary: Adiponectin is a molecule associated with the healthy obese phenotype, affecting insulin sensitivity and providing cardiovascular protection. Studies suggest a potential role of adiponectin in asthma, but its specific effects are still controversial. Research focuses on the mechanisms of adiponectin and its impact on the pathobiology of asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Abbasi, Hanieh Pourjalali, Israel Junior Borges do Nascimento, Nikan Zargarzadeh, Seyed Mohammad Mousavi, Rasoul Eslami, Alireza Milajerdi
Summary: Exercise training has a significant impact on inflammatory biomarkers in breast cancer patients, with a notable reduction in CRP levels, especially evident in long-term interventions and concurrent training. However, no significant changes were observed in serum levels of TNF-alpha, IL-6, IL-8, IL-10, INF-gamma, and IL-1I3 following exercise training. Further research is needed to explore more details in this area.
Article
Nutrition & Dietetics
Sridevi Krishnan, Lauren E. O'Connor, Yu Wang, Erik R. Gertz, Wayne W. Campbell, Brian J. Bennett
Summary: A study found that lower red meat intake leads to decreased TMAO concentrations in the context of a Mediterranean-style eating pattern.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Psychology, Applied
Melissa M. Markofski, Kristofer Jennings, Charles F. Hodgman, Victoria E. Warren, Emily C. LaVoy
Summary: The study found that engaging in physical activity during the pandemic is associated with better mood, especially for participants who were physically active during the pandemic, demonstrating higher positive affect, vigor, and esteem-related affect.
Review
Peripheral Vascular Disease
Yu Wang, Erica R. Hill, Wayne W. Campbell, Lauren E. O'Connor
Summary: Recent randomized controlled feeding trials have shown that consuming plant- and animal-based protein-rich foods plays a significant role in cardiovascular health of adults. However, overall diet quality appears to have a greater impact on improving cardiovascular disease (CVD) risk factors than the intake of a single protein-rich food. Assessing the long-term CVD risk associated with the intake of a single protein-rich food as part of a dietary pattern is methodologically challenging.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Nutrition & Dietetics
Christian S. Wright, Erica R. Hill, Perla C. Reyes Fernandez, William R. Thompson, Maxime A. Gallant, Wayne W. Campbell, Russell P. Main
Summary: Higher protein-energy restriction diets can improve body composition and metabolic health, but their impact on bone is controversial. This study investigated the effect of different protein sources and quantities on bone and body composition in obese, ovariectomized rats. Overall, energy restriction decreased body weight and bone quantity. Weight loss was greater with normal protein diet compared to high protein beef and soy diets, and muscle area decreased only with normal protein diet. The beef diet exacerbated bone loss compared to the soy diet. Results suggest that specific protein source recommendations may be needed to attenuate the adverse effects of high protein-energy restriction diets on bone quality.
Article
Nutrition & Dietetics
Eirini K. Kydonaki, Laura Freitas, Henrique Reguengo, Carlos Raposo Simon, Ana R. Bastos, Emanuel M. Fernandes, Raphael F. Canadas, Joaquim M. Oliveira, Vitor M. Correlo, Rui L. Reis, Maria Vliora, Paraskevi Gkiata, Yiannis Koutedakis, Georgia Ntina, Rui Pinto, Andres E. Carrillo, Franklim Marques, Tania Amorim
Summary: This study compared the effects of different interventions on osteoporosis and found that supplementation with bovine colostrum may have positive effects on bone formation, but is not as effective as alendronate.
Review
Food Science & Technology
Erica R. Hill, Lauren E. O'Connor, Yu Wang, Caroline M. Clark, Bethany S. McGowan, Michele R. Forman, Wayne W. Campbell
Summary: Observational research suggests a link between higher red and processed meat intake and increased risks of cardiovascular diseases and type 2 diabetes. However, experimental evidence is insufficient to establish causality, and there is still debate regarding the relationship.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Yu Wang, Cassi N. Uffelman, Robert E. Bergia, Caroline M. Clark, Jason B. Reed, Tzu-Wen L. Cross, Stephen R. Lindemann, Minghua Tang, Wayne W. Campbell
Summary: Emerging research indicates the importance of gut microbiota in mediating the relationship between meat intake and human health outcomes. This study aimed to assess the available scientific literature on this topic and found that meat intake has differential effects on gut microbiota composition, but the patterns of microbial responses vary across studies. More well-designed prospective studies and full-feeding RCTs are needed to further investigate the relationships and effects of consuming different meat subtypes on gut microbiota.
ADVANCES IN NUTRITION
(2023)
Article
Hematology
Justin C. Crane, Max J. Gordon, Karen Basen-Engquist, Alessandra Ferrajoli, Melissa M. Markofski, Che Young Lee, Sara Fares, Richard J. Simpson, Emily C. LaVoy
Summary: The objective of this study was to examine physical function and T-cell phenotype in CLL patients before and after a physical activity intervention. The results showed that a 16-week intervention of at-home aerobic and/or resistance exercise increased leisure-time PA and decreased fatigue in CLL patients, which correlated with changes in T-cell subsets.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Nutrition & Dietetics
Yu Wang, Stephen R. Lindemann, Tzu-Wen L. Cross, Minghua Tang, Caroline M. Clark, Wayne W. Campbell
Summary: This study aimed to assess the effects of consuming different types of red meat on gut microbiota and fecal short-chain fatty acid levels in healthy young adults. The addition of unprocessed or processed lean red meats to a healthy U.S.-Style Dietary Pattern did not influence short-term changes in bacterial taxonomic composition. However, adopting this dietary pattern led to changes in certain bacteria and improvements in lipid-related cardiovascular risk factors, regardless of red meat intake.
JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Wayne W. Campbell, Nicolaas E. P. Deutz, Elena Volpi, Caroline M. Apovian
Summary: This narrative review discusses the impact of dietary protein intake on muscle-related attributes of older adults. Insufficient protein intake exacerbates age-related reductions in muscle size, quality, and function. Adequate protein intake promotes muscle size and function, with observational studies suggesting higher protein intake may enhance muscle strength and function. Higher protein intake benefits lean body mass changes under stress conditions. Specialized protein supplements can help attenuate muscle loss in older adults with medical conditions or acute illness. Animal protein sources are preferred for sarcopenia-related parameters. The quantity, quality, and patterning of dietary protein intake are important for supporting muscle size and function in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Cassi N. Uffelman, Nok In Chan, Eric M. Davis, Yu Wang, Bethany S. McGowan, Wayne W. Campbell
Summary: Mushroom consumption may have positive effects on cardiometabolic health, particularly on triglycerides and hs-CRP levels. However, the current evidence is limited and inconsistent, with most studies being of poor quality. Further high-quality experimental and observational research is needed to confirm these potential benefits.
Article
Nutrition & Dietetics
Marilena Vitale, Giuseppina Costabile, Robert E. Bergia, Therese Hjorth, Wayne W. Campbell, Rikard Landberg, Gabriele Riccardi, Rosalba Giacco
Summary: Recent evidence suggests that the ability to regulate glucose and insulin homeostasis is different in men and women. This study found that women are more sensitive to the impact of dietary glycemic index (GI) in individuals at high risk of developing type 2 diabetes.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Gavin Connolly, Wayne W. Campbell
Summary: Poultry meats, especially chicken, are highly consumed globally, especially in the United States. Consumption of chicken and poultry has increased significantly in the US over the past six decades. This review highlights the nutritional profiles, consumption trends, and dietary recommendations for chicken/poultry products in the US. Limited evidence suggests that consuming lean unprocessed chicken has beneficial or neutral effects on body weight, cardiovascular disease, and type II diabetes mellitus. However, more research, especially on the effects of consuming processed chicken, is needed.
Article
Nutrition & Dietetics
Viktor Skantze, Therese Hjorth, Mikael Wallman, Carl Brunius, Johan Dicksved, Erik A. Pelve, Anders Esberg, Marilena Vitale, Rosalba Giacco, Giuseppina Costabile, Robert E. Bergia, Mats Jirstrand, Wayne W. Campbell, Gabriele Riccardi, Rikard Landberg
Summary: This study utilized a simple mathematical model to identify two distinct plasma glucose response clusters, which were associated with baseline gut microbiota. The findings suggest that a simple mechanistic model can effectively distinguish non-diabetic individuals at varying risk levels for T2DM.
Article
Food Science & Technology
Cassi N. Uffelman, Katrina A. Doenges, Michael L. Armstrong, Kevin Quinn, Richard M. Reisdorph, Minghua Tang, Nancy F. Krebs, Nichole A. Reisdorph, Wayne W. Campbell
Summary: Research shows that different varieties of mushrooms have different chemical compositions. More than 10,000 compounds were detected in white button, crimini, portabella, lion's mane, maitake, oyster, and shiitake mushrooms. Additionally, lion's mane and oyster mushrooms have high concentrations of the amino acid L-ergothioneine, which has potential antioxidant properties.