Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS ‐mutated human colorectal cancer cells

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells

(2019) Elyssa Bernfeld et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

(2018) Michelle van Geldermalsen et al.   BMC CANCER

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

(2018) Dana M. Gwinn et al.   CANCER CELL

The role of ASCT2 in cancer: A review

(2018) Yang Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of SLC1A5 sensitizes colorectal cancer to cetuximab

(2018) Huanrong Ma et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

(2018) Manuela Porru et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1

(2018) Yuta Hara et al.   CANCER SCIENCE

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anti‐tumor effects of antibodies to L‐type amino‐acid transporter 1 ( LAT 1) bound to human and monkey LAT 1 with dual avidity modes

(2018) Shiho Ueda et al.   CANCER SCIENCE

The ERK and JNK pathways in the regulation of metabolic reprogramming

(2018) Salvatore Papa et al.   ONCOGENE

Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer

(2017) Kosuke Toda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer

(2017) Yasuyuki Okada et al.   MOLECULAR CANCER RESEARCH

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma

(2017) A D Marshall et al.   Oncogenesis

ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production

(2017) Etienne Masle-Farquhar et al.   Frontiers in Immunology

Mutation spectra of RAS gene family in colorectal cancer

(2016) Yu-Yao Chang et al.   AMERICAN JOURNAL OF SURGERY

Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX

(2016) F. Ciardiello et al.   ANNALS OF ONCOLOGY

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate

(2016) Chi Chun Wong et al.   GASTROENTEROLOGY

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

(2016) Josiah E. Hutton et al.   MOLECULAR & CELLULAR PROTEOMICS

Intracellular trafficking and exocytosis of a multi-component siRNA nanocomplex

(2016) Ravi S. Shukla et al.   Nanomedicine-Nanotechnology Biology and Medicine

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

(2016) Wani Arjumand et al.   Oncotarget

Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents

(2016) David Perera et al.   Scientific Reports

Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer

(2016) Masaaki Miyo et al.   Scientific Reports

RAS–Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers

(2016) Hidetoshi Sumimoto et al.   PLoS One

Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer

(2015) T Macarulla et al.   BRITISH JOURNAL OF CANCER

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer

(2015) Khanh Do et al.   INVESTIGATIONAL NEW DRUGS

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Targeting glutamine transport to suppress melanoma cell growth

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

KRAS mutations in non-small-cell lung cancer and colorectal cancer: Implications for EGFR-targeted therapies

(2013) M.K.H. Maus et al.   LUNG CANCER

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

(2013) Daisuke Mashiko et al.   Scientific Reports

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines

(2012) Stéphane Pédeboscq et al.   BIOORGANIC & MEDICINAL CHEMISTRY

KRAS Mutations in Lung Cancer

(2012) Niki Karachaliou et al.   Clinical Lung Cancer

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein

(2010) Takashi Masuko et al.   CANCER SCIENCE

NRAS Mutations Are Rare in Colorectal Cancer

(2010) Natsumi Irahara et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC

(2009) Nicola Normanno et al.   Nature Reviews Clinical Oncology

Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human l-type amino-acid transporter 1

(2008) Yoshiya Ohno et al.   CANCER SCIENCE