- Home
- Publications
- Publication Search
- Publication Details
Title
Regulation of T Helper Cell Fate by TCR Signal Strength
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-05-19
DOI
10.3389/fimmu.2020.00624
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2
- (2019) Dmitri I. Kotov et al. JOURNAL OF IMMUNOLOGY
- BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection
- (2019) Bibo Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA probes that store mechanical information reveal transient piconewton forces applied by T cells
- (2019) Rong Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The regulation of lymphocyte activation and proliferation
- (2018) Susanne Heinzel et al. CURRENT OPINION IN IMMUNOLOGY
- CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection
- (2018) Rakieb Andargachew et al. JOURNAL OF IMMUNOLOGY
- T cell cytolytic capacity is independent of initial stimulation strength
- (2018) Arianne C. Richard et al. NATURE IMMUNOLOGY
- A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk
- (2018) Pauline Gonnord et al. Science Signaling
- Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density
- (2018) John R. James Science Signaling
- IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation
- (2018) Shankar Revu et al. Cell Reports
- Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex
- (2018) Caleb R. Glassman et al. Cell Reports
- A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk
- (2018) Pauline Gonnord et al. Science Signaling
- Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density
- (2018) John R. James Science Signaling
- Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
- (2018) Leah V. Sibener et al. CELL
- Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
- (2018) Daniel DiToro et al. SCIENCE
- The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate
- (2017) Veena Krishnamoorthy et al. IMMUNITY
- Selected signalling proteins recruited to the T-cell receptor-CD3 complex
- (2017) Jatuporn Ngoenkam et al. IMMUNOLOGY
- Rapid G0/1 transition and cell cycle progression in CD8+ T cells compared to CD4+ T cells following in vitro stimulation
- (2017) Takuya Mishima et al. MICROBIOLOGY AND IMMUNOLOGY
- Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination
- (2017) Rafal M. Pielak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TCR Signal Quality Modulates Fate Decisions of Single CD4 + T Cells in a Probabilistic Manner
- (2017) Yi-Li Cho et al. Cell Reports
- Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
- (2016) Christopher Tibbitt et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- pMHC affinity controls duration of CD8 + T cell–DC interactions and imprints timing of effector differentiation versus expansion
- (2016) Aleksandra J. Ozga et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses
- (2016) Susanne Heinzel et al. NATURE IMMUNOLOGY
- Control of T cell antigen reactivity via programmed TCR downregulation
- (2016) Alena M Gallegos et al. NATURE IMMUNOLOGY
- A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli
- (2016) Zachary B Katz et al. NATURE IMMUNOLOGY
- What Scales the T Cell Response?
- (2016) Viveka Mayya et al. TRENDS IN IMMUNOLOGY
- Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
- (2016) Julia Merkenschlager et al. Nature Communications
- Low-affinity CD4+ T cells are major responders in the primary immune response
- (2016) Ryan J. Martinez et al. Nature Communications
- Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells
- (2016) Karmel A Allison et al. eLife
- TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation
- (2016) Nicholas van Panhuys Frontiers in Immunology
- T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells
- (2016) James M. Conley et al. Frontiers in Immunology
- T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
- (2015) Jamie Rossjohn et al. Annual Review of Immunology
- The role of T cell receptor signaling thresholds in guiding T cell fate decisions
- (2015) Julie Zikherman et al. CURRENT OPINION IN IMMUNOLOGY
- Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes
- (2015) G. C. Preston et al. EMBO JOURNAL
- Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells
- (2015) Ilko Kastirr et al. JOURNAL OF IMMUNOLOGY
- Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells
- (2015) Jinsung Hong et al. JOURNAL OF IMMUNOLOGY
- T cell receptor dwell times control the kinase activity of Zap70
- (2015) Christian Klammt et al. NATURE IMMUNOLOGY
- Signaling in Lymphocyte Activation
- (2015) Doreen Cantrell Cold Spring Harbor Perspectives in Biology
- Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response
- (2015) Ryan J. Martinez et al. Frontiers in Immunology
- Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling
- (2014) Baoyu Liu et al. CELL
- T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo
- (2014) Nicholas van Panhuys et al. IMMUNITY
- Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
- (2014) Julio Gomez-Rodriguez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Clonotypic Composition of the CD4+T Cell Response to a Vectored Retroviral Antigen Is Determined by Its Speed
- (2014) Georgina Thorborn et al. JOURNAL OF IMMUNOLOGY
- Antigen Signal Strength during Priming Determines Effector CD4 T Cell Function and Antigen Sensitivity during Influenza Virus Challenge
- (2014) Mika Nagaoka et al. JOURNAL OF IMMUNOLOGY
- Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation
- (2014) S. Keck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
- (2014) J. M. Marchingo et al. SCIENCE
- Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection
- (2013) Noah J. Tubo et al. CELL
- Role of Diacylglycerol Kinases in T Cell Development and Function
- (2013) Sruti Krishna et al. CRITICAL REVIEWS IN IMMUNOLOGY
- T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
- (2013) Kai Yang et al. IMMUNITY
- Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation
- (2013) Shuyu Yao et al. IMMUNITY
- The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells
- (2013) Francesco Marangoni et al. IMMUNITY
- Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype
- (2013) Dirk Baumjohann et al. IMMUNITY
- A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells
- (2013) Jun Huang et al. IMMUNITY
- Insights into the Role of Bcl6 in Follicular Th Cells Using a New Conditional Mutant Mouse Model
- (2013) K. Hollister et al. JOURNAL OF IMMUNOLOGY
- Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory
- (2013) Y. S. Choi et al. JOURNAL OF IMMUNOLOGY
- The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
- (2013) Kevin Man et al. NATURE IMMUNOLOGY
- Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
- (2013) Clifford S Guy et al. NATURE IMMUNOLOGY
- Heterogeneous Differentiation Patterns of Individual CD8+ T Cells
- (2013) C. Gerlach et al. SCIENCE
- A new look at T cell receptor signaling to nuclear factor-κB
- (2013) Suman Paul et al. TRENDS IN IMMUNOLOGY
- Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?
- (2012) Selena Viganò et al. Clinical & Developmental Immunology
- T-follicular helper cells survive as long-term memory cells
- (2012) Jan P. Weber et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
- (2012) Carolyn G. King et al. IMMUNITY
- The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function
- (2012) Jia-huai Wang et al. IMMUNOLOGICAL REVIEWS
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
- (2012) Stephanie M. Stanford et al. IMMUNOLOGY
- STAT5 is a potent negative regulator of TFHcell differentiation
- (2012) Robert J. Johnston et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells
- (2012) A. T. Waickman et al. JOURNAL OF IMMUNOLOGY
- A TCR Affinity Threshold Regulates Memory CD4 T Cell Differentiation following Vaccination
- (2012) C. K. Baumgartner et al. JOURNAL OF IMMUNOLOGY
- Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics
- (2012) Kristen M. Rosenthal et al. PLoS One
- Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
- (2012) R. A. Gottschalk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
- (2012) Aditi Kanhere et al. Nature Communications
- All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells
- (2012) Christopher J. Gamper et al. Frontiers in Immunology
- TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling
- (2012) Sun Taek Kim et al. Frontiers in Immunology
- Follicular Helper CD4 T Cells (TFH)
- (2011) Shane Crotty Annual Review of Immunology
- NF-κB in immunobiology
- (2011) Matthew S Hayden et al. CELL RESEARCH
- T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex
- (2011) Jarrett J. Adams et al. IMMUNITY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells
- (2011) Marion Pepper et al. IMMUNITY
- Regulation of NF-κB induction by TCR/CD28
- (2011) Jing Cheng et al. IMMUNOLOGIC RESEARCH
- Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection
- (2011) James M. Ertelt et al. IMMUNOLOGY
- Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell Activation
- (2011) Jing Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses
- (2011) Joseph J. Sabatino et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Role of Two Adaptor Molecules SLP-76 and LAT in the PI3K Signaling Pathway in Activated T Cells
- (2011) E. K. Shim et al. JOURNAL OF IMMUNOLOGY
- B Cells and TCR Avidity Determine Distinct Functions of CD4+ T Cells in Retroviral Infection
- (2011) M. J.- Y. Ploquin et al. JOURNAL OF IMMUNOLOGY
- Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
- (2011) E. Corse et al. JOURNAL OF IMMUNOLOGY
- Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number
- (2011) J. Quiel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiation of Effector CD4 T Cell Populations
- (2010) Jinfang Zhu et al. Annual Review of Immunology
- Low-strength T-cell activation promotes Th17 responses
- (2010) H. A. Purvis et al. BLOOD
- Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
- (2010) Konstantina Nika et al. IMMUNITY
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Ca 2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor
- (2010) Ji-Li Chen et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: TCR Ligation Triggers Digital Activation of NF- B
- (2010) L. M. Kingeter et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Lack of High Affinity Competition for Peptide in Polyclonal CD4+ Responses Unmasks IL-4 Production
- (2010) J. D. Milner et al. JOURNAL OF IMMUNOLOGY
- Fast on-rates allow short dwell time ligands to activate T cells
- (2010) C. C. Govern et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
- (2010) S. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The TCR-mediated signaling pathways that control the direction of helper T cell differentiation
- (2010) Toshinori Nakayama et al. SEMINARS IN IMMUNOLOGY
- Perspectives for Computer Modeling in the Study of T Cell Activation
- (2010) J. Coward et al. Cold Spring Harbor Perspectives in Biology
- An Enigmatic Tail of CD28 Signaling
- (2010) J. S. Boomer et al. Cold Spring Harbor Perspectives in Biology
- Attenuated T Cell Responses to a High-Potency Ligand In Vivo
- (2010) Emily Corse et al. PLOS BIOLOGY
- Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells
- (2009) Jayajit Das et al. CELL
- IL-4–producing CD4+T cells in reactive lymph nodes during helminth infection are T follicular helper cells
- (2009) Irah L. King et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Differential Regulation of IL-4R Expression by Antigen versus Cytokine Stimulation Characterizes Th2 Progression In Vivo
- (2009) G. Perona-Wright et al. JOURNAL OF IMMUNOLOGY
- Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion
- (2009) M. S. Turner et al. JOURNAL OF IMMUNOLOGY
- Cell Cycle Progression following Naive T Cell Activation Is Independent of Jak3/Common -Chain Cytokine Signals
- (2009) M. Shi et al. JOURNAL OF IMMUNOLOGY
- Complete but curtailed T-cell response to very low-affinity antigen
- (2009) Dietmar Zehn et al. NATURE
- The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
- (2009) Nicolas Fazilleau et al. NATURE IMMUNOLOGY
- Cytokine-secreting follicular T cells shape the antibody repertoire
- (2009) R Lee Reinhardt et al. NATURE IMMUNOLOGY
- CD40–CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
- (2009) Giandomenica Iezzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif
- (2008) Chenqi Xu et al. CELL
- Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK
- (2008) H. C. Dan et al. GENES & DEVELOPMENT
- Vaccine Adjuvants Alter TCR-Based Selection Thresholds
- (2008) Laurent Malherbe et al. IMMUNITY
- T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
- (2008) Sarah E Henrickson et al. NATURE IMMUNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now