Control of T cell antigen reactivity via programmed TCR downregulation

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

SHP-1 phosphatase activity counteracts increased T cell receptor affinity

(2013) Michael Hebeisen et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation

(2013) Jeroen W J van Heijst et al.   NATURE MEDICINE

T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

(2012) Carolyn G. King et al.   IMMUNITY

Maintaining system homeostasis: the third law of Newtonian immunology

(2012) Ronald N Germain   NATURE IMMUNOLOGY

Distinct CD4+ helper T cells involved in primary and secondary responses to infection

(2012) K. S. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas

(2011) Jackson G. Egen et al.   IMMUNITY

Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses

(2011) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Suboptimal Activation of Antigen-Specific CD4+ Effector Cells Enables Persistence of M. tuberculosis In Vivo

(2011) Tyler D. Bold et al.   PLoS Pathogens

A Gamma Interferon Independent Mechanism of CD4 T Cell Mediated Control of M. tuberculosis Infection in vivo

(2011) Alena M. Gallegos et al.   PLoS Pathogens

Attenuated T Cell Responses to a High-Potency Ligand In Vivo

(2010) Emily Corse et al.   PLOS BIOLOGY

Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa

(2009) Stephen D Lawn et al.   AIDS

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

Delayed protection by ESAT-6–specific effector CD4+T cells after airborneM. tuberculosisinfection

(2008) Alena M. Gallegos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

(2008) Angel Varela-Rohena et al.   NATURE MEDICINE