Selected signalling proteins recruited to the T-cell receptor-CD3 complex

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain

(2016) Ren Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

(2016) Alice Y. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

(2016) Zachary B Katz et al.   NATURE IMMUNOLOGY

Sclerosing cholangitis and intracranial lymphoma in a child with classical Wiskott-Aldrich syndrome

(2016) Pandiarajan Vignesh et al.   PEDIATRIC BLOOD & CANCER

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

(2016) A. Borroto et al.   Science Translational Medicine

T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells

(2015) Cecilie Dahl Hem et al.   Cell Communication and Signaling

CD3ε recruits Numb to promote TCR degradation

(2015) Nadia Martin-Blanco et al.   INTERNATIONAL IMMUNOLOGY

T-cell receptor diversity is selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome

(2015) Junfeng Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning

(2015) Pussadee Paensuwan et al.   JOURNAL OF IMMUNOLOGY

T cell receptor dwell times control the kinase activity of Zap70

(2015) Christian Klammt et al.   NATURE IMMUNOLOGY

Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation

(2014) Jatuporn Ngoenkam et al.   Cell Communication and Signaling

Insight into the therapeutic aspects of ‘Zeta-Chain Associated Protein Kinase 70kDa’ inhibitors: A review

(2014) Maninder Kaur et al.   CELLULAR SIGNALLING

Crammed signaling motifs in the T-cell receptor

(2014) Aldo Borroto et al.   IMMUNOLOGY LETTERS

The Proline-Rich Sequence of CD3  as an Amplifier of Low-Avidity TCR Signaling

(2014) P. Tailor et al.   JOURNAL OF IMMUNOLOGY

The adapter proteins ADAP and Nck cooperate in T cell adhesion

(2014) Marcus Lettau et al.   MOLECULAR IMMUNOLOGY

The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192

(2014) S. Granum et al.   Science Signaling

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

(2014) Javier Casas et al.   Nature Communications

Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1型糖尿病患者外周血单个核细胞miR-146表达下调与胰岛持续免疫失衡相关

(2014) Minglan Yang et al.   Journal of Diabetes

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

(2013) Himadri Mukhopadhyay et al.   PLoS Computational Biology

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

(2012) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

(2012) Jérémie Rossy et al.   Frontiers in Immunology

The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division

(2010) R. Aguado et al.   BLOOD

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Characterization of ζ-associated protein, 70 kd (ZAP70)–deficient human lymphocytes

(2010) Chaim M. Roifman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers

(2010) Chiara Ferrandi et al.   Multiple Sclerosis Journal

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

(2010) Hee-Don Chae et al.   PLoS One

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Nck adapter proteins: functional versatility in T cells

(2009) Marcus Lettau et al.   Cell Communication and Signaling

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling

(2009) Pilar Delgado et al.   NATURE IMMUNOLOGY

Checkpoints in lymphocyte development and autoimmune disease

(2009) Harald von Boehmer et al.   NATURE IMMUNOLOGY

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

(2009) S. Deindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Actin Cytoskeleton in T Cell Activation

(2008) Janis K. Burkhardt et al.   Annual Review of Immunology

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

(2008) Michaël Mingueneau et al.   NATURE IMMUNOLOGY

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY

Kinase inhibitors for the treatment of inflammatory and autoimmune disorders

(2008) Shripad S. Bhagwat   Purinergic Signalling