Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

Multisite Phosphorylation Modulates the T Cell Receptor ζ -Chain Potency but not the Switchlike Response

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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

(2016) Karmel A Allison et al.   eLife

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

(2016) Neel H Shah et al.   eLife

TCR ITAM multiplicity is required for the generation of follicular helper T-cells

(2015) SuJin Hwang et al.   Nature Communications

CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

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Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

(2013) Himadri Mukhopadhyay et al.   PLoS Computational Biology

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

(2010) Guoping Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection

(2010) Michel Mallaun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

The structure, regulation, and function of ZAP-70

(2009) Byron B. Au-Yeung et al.   IMMUNOLOGICAL REVIEWS

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY