DNA probes that store mechanical information reveal transient piconewton forces applied by T cells

DNA Nanotechnology as an Emerging Tool to Study Mechanotransduction in Living Systems

(2019) Victor Pui‐Yan Ma et al.   Small

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse

(2018) Viveka Mayya et al.   Cell Reports

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

A TCR mechanotransduction signaling loop induces negative selection in the thymus

(2018) Jinsung Hong et al.   NATURE IMMUNOLOGY

In situandin silicokinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network

(2017) Kaitao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation

(2017) Yun Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

(2017) En Cai et al.   SCIENCE

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire

(2016) Susanne G. Oberle et al.   Cell Reports

Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

(2016) Catherine A Hartzell et al.   eLife

The coreceptor programmed death 1 inhibits T-cell adhesion by regulating Rap1

(2015) Inbar Azoulay-Alfaguter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

The bright future of single-molecule fluorescence imaging

(2014) Manuel F Juette et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A DNA-based molecular probe for optically reporting cellular traction forces

(2014) Brandon L Blakely et al.   NATURE METHODS

DNA-based digital tension probes reveal integrin forces during early cell adhesion

(2014) Yun Zhang et al.   Nature Communications

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

(2014) Cristina Godinho-Silva et al.   PLoS Pathogens

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Kinetics and Dynamics of DNA Hybridization

(2011) Yandong Yin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visualizing mechanical tension across membrane receptors with a fluorescent sensor

(2011) Daniel R Stabley et al.   NATURE METHODS

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

(2010) Georges A. Azar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS