PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia

PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+T Cells

(2015) Hyo Jin Park et al.   JOURNAL OF IMMUNOLOGY

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

(2015) Vijayakumar Velu et al.   Retrovirology

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Immunologic and Clinical Effects of Targeting PD-1 in Lung Cancer

(2014) R D Harvey   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Animal models for viral infection and cell exhaustion

(2014) Colleen S. McGary et al.   Current Opinion in HIV and AIDS

Cell exhaustion in HIV-1 infection

(2014) Nabila Seddiki et al.   Current Opinion in HIV and AIDS

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

(2014) Nathan L. Bowers et al.   PLoS Pathogens

The phenotype and activation status of regulatory T cells during Friend retrovirus infection

(2014) Jara J. Joedicke et al.   VIROLOGICA SINICA

Induction, control, and plasticity of Treg cells: The immune regulatory network revised?

(2013) Vincenzo Barnaba et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease

(2013) M. Wong et al.   JOURNAL OF IMMUNOLOGY

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Incomplete Normalization of Regulatory T-Cell Frequency in the Gut Mucosa of Colombian HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment

(2013) Cesar M. Rueda et al.   PLoS One

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

(2013) Edward Seung et al.   PLoS One

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

(2013) M. J. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8+ T Cells and Efficiently Reduces Chronic Retroviral Loads

(2013) Kirsten K. Dietze et al.   PLoS Pathogens

CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection

(2013) Federico Simonetta et al.   Frontiers in Immunology

The split personality of regulatory T cells in HIV infection

(2012) M. F. Chevalier et al.   BLOOD

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

(2012) Ravi Dyavar Shetty et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice

(2012) B. E. Palmer et al.   JOURNAL OF IMMUNOLOGY

Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

(2012) M. E. Moreno-Fernandez et al.   JOURNAL OF VIROLOGY

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

(2012) J. Gotot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

(2011) F. Porichis et al.   BLOOD

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Role of PD-1 in HIV Pathogenesis and as Target for Therapy

(2011) Filippos Porichis et al.   Current HIV/AIDS Reports

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

(2010) Q. Zhou et al.   BLOOD

Features of responding T cells in cancer and chronic infection

(2010) Peter S Kim et al.   CURRENT OPINION IN IMMUNOLOGY

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

(2010) M. Rodriguez-Garcia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands

(2009) Angela Meier et al.   AIDS

Regulatory T Cells in the Control of Host-Microorganism Interactions

(2009) Yasmine Belkaid et al.   Annual Review of Immunology

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

CD4+ and CD8+ T Cells Expressing FoxP3 in HIV-Infected Patients Are Phenotypically Distinct and Influenced by Disease Severity and Antiretroviral Therapy

(2009) Andrew Lim et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

(2009) Debora Franceschini et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: Restricted expression of type I interferon receptor by CCR5-expressing leukocytes

(2008) Adriano Boasso et al.   CLINICAL IMMUNOLOGY

The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

(2008) Milica Vukmanovic-Stejic et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA