CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

(2018) Jun Wang et al.   CELL

Increasing LAG-3 expression suppresses T-cell function in chronic hepatitis B

(2017) Bo Ye et al.   MEDICINE

Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM

(2015) Zhenling Deng et al.   BMC IMMUNOLOGY

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B

(2015) Sachiyo Yoshio et al.   HEPATOLOGY

The Expression of Programmed Death-1 in Circulating CD4+and CD8+T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics

(2014) Ping Xu et al.   Gut and Liver

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

(2014) A. Gibson et al.   JOURNAL OF IMMUNOLOGY

Acute and Chronic B Cell Depletion Disrupts CD4+and CD8+T Cell Homeostasis and Expansion during Acute Viral Infection in Mice

(2014) Jacquelyn M. Lykken et al.   JOURNAL OF IMMUNOLOGY

Postnatal Acquisition of Primary Rhesus Cytomegalovirus Infection is Associated With Prolonged Virus Shedding and Impaired CD4+ T Lymphocyte Function

(2014) Pierre Antoine et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

Cellular immune response in patients with chronic hepatitis B virus infection

(2014) Xuefen Li et al.   MICROBIAL PATHOGENESIS

CD4+ T-Cell Help Is Required for Effective CD8+ T Cell-Mediated Resolution of Acute Viral Hepatitis in Mice

(2014) Tanja Trautmann et al.   PLoS One

Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules

(2014) Bijan Raziorrouh et al.   PLoS One

Characteristics of splenic CD8+T cell exhaustion in patients with hepatitis C

(2013) K. Sumida et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD8+T Cell Exhaustion During Persistent Viral Infection is Regulated Independently of the Virus-Specific T Cell Receptor

(2013) Stephanie R. Jackson et al.   IMMUNOLOGICAL INVESTIGATIONS

Increased regulatory T cells and impaired functions of circulating CD8 T lymphocytes is associated with viral persistence in Hepatitis B virus-positive newborns

(2013) S. Shrivastava et al.   JOURNAL OF VIRAL HEPATITIS

Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1

(2012) Guangxu Ren et al.   AIDS

Antigen amount dictates CD8+T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell

(2012) Kirsten Richter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues

(2012) Carolina Boni et al.   GASTROENTEROLOGY

Immunopathogenesis and prognostic immune markers of chronic hepatitis B virus infection

(2011) Zheng Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

(2010) Bijan Raziorrouh et al.   HEPATOLOGY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells

(2009) J. F. Grosso et al.   JOURNAL OF IMMUNOLOGY

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion

(2008) Alexander Evans et al.   HEPATOLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients

(2007) Guoping Peng et al.   MOLECULAR IMMUNOLOGY