Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade

Roles, function and relevance of LAG3 in HIV infection

(2019) Colin G. Graydon et al.   PLoS Pathogens

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

Peripheral PD-1+ T Cells Co-expressing Inhibitory Receptors Predict SVR With Ultra Short Duration DAA Therapy in HCV Infection

(2019) Sara Romani et al.   Frontiers in Immunology

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

(2018) Marina Wierz et al.   BLOOD

Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis

(2018) Nathaniel Meyer et al.   CRITICAL CARE MEDICINE

Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer

(2018) Yunxuan Wang et al.   Journal of Breast Cancer

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

(2018) Felix S. Lichtenegger et al.   Frontiers in Immunology

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

(2018) Yean K. Yong et al.   Frontiers in Immunology

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

(2018) Guoying Zhou et al.   OncoImmunology

Drug response to PD-1/PD-L1 blockade: based on biomarkers

(2018) Qi Chen et al.   OncoTargets and Therapy

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression

(2018) Yingjun Liu et al.   Scientific Reports

Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis

(2018) Qiang Zhang et al.   Biomed Research International

Oxygen Saturation on Admission Is a Predictive Biomarker for PD-L1 Expression on Circulating Monocytes and Impaired Immune Response in Patients With Sepsis

(2018) José Avendaño-Ortiz et al.   Frontiers in Immunology

Precision Immunotherapy for Sepsis

(2018) Annemieke M. Peters van Ton et al.   Frontiers in Immunology

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

(2018) Jun Wang et al.   CELL

Focus on sepsis: new concepts and findings in sepsis care

(2018) Jean-Francois Timsit et al.   INTENSIVE CARE MEDICINE

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses

(2018) Alireza Saeidi et al.   Frontiers in Immunology

LAG3 (CD223) as a cancer immunotherapy target

(2017) Lawrence P. Andrews et al.   IMMUNOLOGICAL REVIEWS

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit

(2017) Eamon P. Raith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-PD-L1 peptide improves survival in sepsis

(2017) Yuichiro Shindo et al.   JOURNAL OF SURGICAL RESEARCH

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

(2017) Jason Pinger et al.   Nature Communications

Lymphocyte-activation gene-3, an important immune checkpoint in cancer

(2016) Yayi He et al.   CANCER SCIENCE

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

Cooperation of PD-1 and LAG-3 Contributes to T-Cell Exhaustion in Anaplasma marginale-Infected Cattle

(2016) Tomohiro Okagawa et al.   INFECTION AND IMMUNITY

Basics of PD-1 in self-tolerance, infection, and cancer immunity

(2016) Shunsuke Chikuma   International Journal of Clinical Oncology

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lymphocyte-activation gene 3 + (LAG3 + ) forkhead box protein 3 − (FOXP3 − ) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis

(2016) Szu-Ying Chen et al.   JOURNAL OF AUTOIMMUNITY

Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection withPlasmodiumparasites

(2016) Henrietta T. Doe et al.   MICROBIOLOGY AND IMMUNOLOGY

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression

(2016) Naeem K. Patil et al.   PHARMACOLOGICAL RESEARCH

Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

(2016) Atsushi Kadowaki et al.   Nature Communications

Experimental Persistent Infection of BALB/c Mice with Small-Colony Variants of Burkholderia pseudomallei Leads to Concurrent Upregulation of PD-1 on T Cells and Skewed Th1 and Th17 Responses

(2016) Jia-Xiang See et al.   PLoS Neglected Tropical Diseases

SnapShot: T Cell Exhaustion

(2015) Kristen E. Pauken et al.   CELL

Role of Circulating Lymphocytes in Patients with Sepsis

(2014) Raul de Pablo et al.   Biomed Research International

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

(2011) Taku Okazaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis

(2009) Christian Torgersen et al.   ANESTHESIA AND ANALGESIA

Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells

(2009) J. F. Grosso et al.   JOURNAL OF IMMUNOLOGY