Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

Cutting Edge: Programmed Death-1 Expression Is Increased on Immunocytes in Chronic Hepatitis C Virus and Predicts Failure of Response to Antiviral Therapy: Race-Dependent Differences

(2014) L. Golden-Mason et al.   JOURNAL OF IMMUNOLOGY

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Unraveling the Role of PD-1/PD-L Interactions in Persistent Hepatotropic Infections: Potential for Therapeutic Application?

(2008) Henry Radziewicz et al.   GASTROENTEROLOGY

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis

(2008) David E. Kaplan et al.   JOURNAL OF HEPATOLOGY

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

(2008) Simona Urbani et al.   JOURNAL OF HEPATOLOGY

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

(2008) H. Radziewicz et al.   JOURNAL OF VIROLOGY

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

(2008) H. Ebinuma et al.   JOURNAL OF VIROLOGY

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 trafficking and surface expression

(2008) Elke Valk et al.   TRENDS IN IMMUNOLOGY