If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Moral Limits of Brain Organoid Research

(2020) Julian J. Koplin et al.   JOURNAL OF LAW MEDICINE & ETHICS

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Are There Islands of Awareness?

(2019) Tim Bayne et al.   TRENDS IN NEUROSCIENCES

NIA commentary on the NIA-AA Research Framework: Towards a biological definition of Alzheimer’s disease

(2018) Nina Silverberg et al.   Alzheimers & Dementia

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Simultaneous Aerobic Exercise and Memory Training Program in Older Adults with Subjective Memory Impairments

(2018) Sarah C. McEwen et al.   JOURNAL OF ALZHEIMERS DISEASE

Ethical (and epistemological) issues regarding consciousness in cerebral organoids

(2018) Joshua Shepherd   JOURNAL OF MEDICAL ETHICS

Manipulation of neural progenitor fate through the oxygen sensing pathway

(2018) Yuan Xie et al.   METHODS

The ethics of experimenting with human brain tissue

(2018) Nita A. Farahany et al.   NATURE

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

(2018) Heidi I. L. Jacobs et al.   NATURE NEUROSCIENCE

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Global View on Alzheimer’s Disease and Diabetes Mellitus: Threats, Risks and Treatment

(2018) Blanka Klimova et al.   Current Alzheimer Research

Can We Do Better? Researchers' Experiences with Ethical Review Boards on Projects with Later Life as a Focus

(2018) Nancy A. Pachana et al.   JOURNAL OF ALZHEIMERS DISEASE

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

(2018) Celeste M. Karch et al.   Alzheimers Research & Therapy

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

(2018) Viola Volpato et al.   Stem Cell Reports

Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife

(2018) Lindsay R. Clark et al.   Alzheimers & Dementia

Biomarkers for diseases with TDP-43 pathology

(2018) Petra Steinacker et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

(2018) Miia Kivipelto et al.   Nature Reviews Neurology

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

(2018) Serena Pavoni et al.   PLoS One

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium

(2018) Bernt Popp et al.   Scientific Reports

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

(2018) Farid Rajabli et al.   PLoS Genetics

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records

(2018) Dominika Seblova et al.   Clinical Epidemiology

Dementia prevention, intervention, and care

(2017) Gill Livingston et al.   LANCET

Association Between Exercise Capacity and Late Onset of Dementia, Alzheimer Disease, and Cognitive Impairment

(2017) Jan Müller et al.   MAYO CLINIC PROCEEDINGS

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Molecular and functional variation in iPSC-derived sensory neurons

(2017) Jeremy Schwartzentruber et al.   NATURE GENETICS

Imaging and fluid biomarkers in frontotemporal dementia

(2017) Lieke H. Meeter et al.   Nature Reviews Neurology

The changing prevalence and incidence of dementia over time — current evidence

(2017) Yu-Tzu Wu et al.   Nature Reviews Neurology

Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target

(2017) Youmei Wang et al.   Neurodegenerative Diseases

Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

(2017) Jessica Mira Gabin et al.   Alzheimers Research & Therapy

APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts

(2017) Jing Qian et al.   PLOS MEDICINE

Voting on Embryonic Stem Cell Research: Citizens More Supportive than Politicians

(2017) David Stadelmann et al.   PLoS One

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

(2016) Erin L. Abner et al.   Alzheimers & Dementia

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)

(2016) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aβ-related memory decline inAPOEε4 noncarriers

(2016) Yen Ying Lim et al.   NEUROLOGY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines

(2016) George Q. Daley et al.   Stem Cell Reports

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities

(2015) Mario M. Dorostkar et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Common polygenic variation enhances risk prediction for Alzheimer’s disease

(2015) Valentina Escott-Price et al.   BRAIN

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months

(2015) Christine Thai et al.   PLoS One

Identifiability and Privacy in Pluripotent Stem Cell Research

(2014) Rosario Isasi et al.   Cell Stem Cell

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Alzheimer's disease: The forgetting gene

(2014) Laura Spinney   NATURE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Targeted MOOC captivates students

(2013) Carolyn King et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

(2013) T. Hedden et al.   NEUROLOGY

A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior

(2013) A. G. Casali et al.   Science Translational Medicine

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease

(2013) Rik Vandenberghe et al.   NeuroImage-Clinical

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

 -Amyloid burden in healthy aging: Regional distribution and cognitive consequences

(2012) K. M. Rodrigue et al.   NEUROLOGY

Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention

(2012) M Valenzuela et al.   Translational Psychiatry

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

(2011) William E. Klunk   NEUROBIOLOGY OF AGING

Neuropathology of Alzheimer's Disease

(2010) Daniel P. Perl   MOUNT SINAI JOURNAL OF MEDICINE

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

(2010) Matthias Stadtfeld et al.   NATURE

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

(2010) Jose M Polo et al.   NATURE BIOTECHNOLOGY

Disclosure ofAPOEGenotype for Risk of Alzheimer's Disease

(2009) Robert C. Green et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevalence of dementia after age 90: Results from The 90+ Study

(2008) M. M. Corrada et al.   NEUROLOGY