Imaging and fluid biomarkers in frontotemporal dementia

Blood-based NfL

(2017) Oskar Hansson et al.   NEUROLOGY

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72 -associated amyotrophic lateral sclerosis

(2017) Tania F. Gendron et al.   Science Translational Medicine

Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

(2016) Ruben Smith et al.   ACTA NEUROPATHOLOGICA

MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases

(2016) Lorna Harper et al.   BRAIN

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

On the right side? A longitudinal study of left- versus right-lateralized semantic dementia

(2016) Fiona Kumfor et al.   BRAIN

Pathophysiology of the behavioral variant of frontotemporal lobar degeneration: A study combining MRI and FDG-PET

(2016) M-S. Buhour et al.   Brain Imaging and Behavior

Vulnerability of microRNA biogenesis in FTD–ALS

(2016) Chen Eitan et al.   BRAIN RESEARCH

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Tau imaging with [18F]THK-5351 in progressive supranuclear palsy

(2016) A. Ishiki et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mapping brain morphological and functional conversion patterns in predementia late-onset bvFTD

(2016) Silvia Morbelli et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Cerebrospinal Fluid Biomarkers as a Diagnostic Tool of the Underlying Pathology of Primary Progressive Aphasia

(2016) George P. Paraskevas et al.   JOURNAL OF ALZHEIMERS DISEASE

Looking for Neuroimaging Markers in Frontotemporal Lobar Degeneration Clinical Trials: A Multi-Voxel Pattern Analysis Study in Granulin Disease

(2016) Enrico Premi et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Biomarkers for the Differential Diagnosis between Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Systematic Review, HSROC Analysis, and Confounding Factors

(2016) Amado Rivero-Santana et al.   JOURNAL OF ALZHEIMERS DISEASE

Diagnostic Accuracy of MRI and Additional [18F]FDG-PET for Behavioral Variant Frontotemporal Dementia in Patients with Late Onset Behavioral Changes

(2016) Everard G.B. Vijverberg et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia

(2016) Chiara Cerami et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Rather than TDP-43 Proteins are Potential Cerebrospinal Fluid Biomarkers for Frontotemporal Lobar Degeneration Subtypes: A Pilot Study

(2016) H. Bea Kuiperij et al.   JOURNAL OF ALZHEIMERS DISEASE

Advances in neuroimaging in frontotemporal dementia

(2016) Elizabeth Gordon et al.   JOURNAL OF NEUROCHEMISTRY

Genetics of FTLD: overview and what else we can expect from genetic studies

(2016) Cyril Pottier et al.   JOURNAL OF NEUROCHEMISTRY

Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum

(2016) Carlo Wilke et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia

(2016) Jonathan D. Rohrer et al.   NEUROLOGY

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET

(2016) Akio Kikuchi et al.   NEUROLOGY

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

(2016) Mehtap Bacioglu et al.   NEURON

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

(2016) Jie Jiang et al.   NEURON

Diagnostic and prognostic significance of neurofilament light chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net

(2016) Petra Steinacker et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study

(2016) Elise G.P. Dopper et al.   NeuroImage-Clinical

Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD

(2016) Duygu Tosun et al.   Annals of Clinical and Translational Neurology

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy

(2016) Julio C. Rojas et al.   Annals of Clinical and Translational Neurology

Neurofilament light chain: a biomarker for genetic frontotemporal dementia

(2016) Lieke H. Meeter et al.   Annals of Clinical and Translational Neurology

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

Cerebrospinal fluid proteomics and protein biomarkers in frontotemporal lobar degeneration: Current status and future perspectives

(2015) Patrick Oeckl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia

(2015) Jennifer L. Whitwell et al.   BRAIN AND LANGUAGE

Inflammatory molecules in Frontotemporal Dementia: Cerebrospinal fluid signature of progranulin mutation carriers

(2015) D. Galimberti et al.   BRAIN BEHAVIOR AND IMMUNITY

Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability

(2015) Anthony Fourier et al.   CLINICA CHIMICA ACTA

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion

(2015) Anna K�m�l�inen et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images

(2015) J. L. Whitwell et al.   EUROPEAN JOURNAL OF NEUROLOGY

Early-stage differentiation between presenile Alzheimer’s disease and frontotemporal dementia using arterial spin labeling MRI

(2015) Rebecca M. E. Steketee et al.   EUROPEAN RADIOLOGY

Cerebral perfusion and glucose metabolism in Alzheimer’s disease and frontotemporal dementia: two sides of the same coin?

(2015) Sander C. J. Verfaillie et al.   EUROPEAN RADIOLOGY

Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease

(2015) Anne Hafkemeijer et al.   Frontiers in Human Neuroscience

MRI signatures of the frontotemporal lobar degeneration continuum

(2015) Federica Agosta et al.   HUMAN BRAIN MAPPING

Progranulin as a candidate biomarker for therapeutic trial in patients with ALS and FTLD

(2015) Emily Feneberg et al.   JOURNAL OF NEURAL TRANSMISSION

Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration

(2015) Aiko Ishiki et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid and FDG-PET study of logopenic primary progressive aphasia: evidence for the existence of two subtypes

(2015) Jordi A. Matías-Guiu et al.   JOURNAL OF NEUROLOGY

Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study

(2015) M. Tahmasian et al.   JOURNAL OF NUCLEAR MEDICINE

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

(2015) Jonathan D Rohrer et al.   LANCET NEUROLOGY

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo

(2015) A Yuan et al.   MOLECULAR PSYCHIATRY

Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

(2015) Linda Gibbons et al.   NEUROBIOLOGY OF AGING

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

(2015) C.-H. Lu et al.   NEUROLOGY

Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

(2015) Joery Goossens et al.   Acta Neuropathologica Communications

Longitudinal diffusion tensor imaging in frontotemporal dementia

(2014) Colin J. Mahoney et al.   ANNALS OF NEUROLOGY

Fully-Automated Volumetric MRI with Normative Ranges: Translation to Clinical Practice

(2014) J. B. Brewer   BEHAVIOURAL NEUROLOGY

Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion

(2014) S. E. Lee et al.   BRAIN

Conceptualizing neuropsychiatric diseases with multimodal data-driven meta-analyses – The case of behavioral variant frontotemporal dementia

(2014) Matthias L. Schroeter et al.   CORTEX

Imaging Frontotemporal Lobar Degeneration

(2014) Janine Diehl-Schmid et al.   Current Neurology and Neuroscience Reports

The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients

(2014) Angelina Cistaro et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Distinct perfusion patterns in Alzheimer’s disease, frontotemporal dementia and dementia with Lewy bodies

(2014) Maja A. A. Binnewijzend et al.   EUROPEAN RADIOLOGY

The power of neuroimaging biomarkers for screening frontotemporal dementia

(2014) Corey T. McMillan et al.   HUMAN BRAIN MAPPING

Profiles of white matter tract pathology in frontotemporal dementia

(2014) Colin J. Mahoney et al.   HUMAN BRAIN MAPPING

Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia

(2014) David C. Alsop et al.   MAGNETIC RESONANCE IN MEDICINE

Disrupted brain connectome in semantic variant of primary progressive aphasia

(2014) Federica Agosta et al.   NEUROBIOLOGY OF AGING

Phonologic errors as a clinical marker of the logopenic variant of PPA

(2014) C. E. Leyton et al.   NEUROLOGY

Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia

(2014) E. G. P. Dopper et al.   NEUROLOGY

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

(2014) T. Skillback et al.   NEUROLOGY

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

Multimodal fMRI Resting-State Functional Connectivity in Granulin Mutations: The Case of Fronto-Parietal Dementia

(2014) Enrico Premi et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia

(2014) Barbara Borroni et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology

(2014) Robert Laforce et al.   NeuroImage-Clinical

PET Approaches for Diagnosis of Dementia

(2013) K. Ishii   AMERICAN JOURNAL OF NEURORADIOLOGY

Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration

(2013) Carole S. Scherling et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia

(2013) Maria Landqvist Waldö et al.   BMC Neurology

Anterior temporal lobe degeneration produces widespread network-driven dysfunction

(2013) Christine C. Guo et al.   BRAIN

Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation

(2013) M. Teichmann et al.   BRAIN

GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia

(2013) Riikka Rytty et al.   Frontiers in Human Neuroscience

Longitudinal white matter changes in frontotemporal dementia subtypes

(2013) Bonnie Y. K. Lam et al.   HUMAN BRAIN MAPPING

White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration

(2013) C. T. McMillan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

White matter tract signatures of the progressive aphasias

(2013) Colin J. Mahoney et al.   NEUROBIOLOGY OF AGING

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

(2013) C. Jacova et al.   NEUROLOGY

Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP

(2013) W. T. Hu et al.   NEUROLOGY

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

CSF biomarkers cutoffs: the importance of coincident neuropathological diseases

(2012) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics

(2012) J. L. Whitwell et al.   BRAIN

Functional network connectivity in the behavioral variant of frontotemporal dementia

(2012) Massimo Filippi et al.   CORTEX

Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation

(2012) Norman A.S. Farb et al.   CORTEX

Gray Matter Atrophy in Behavioral Variant Frontotemporal Dementia: A Meta-Analysis of Voxel-Based Morphometry Studies

(2012) Ping Lei Pan et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Neuroimaging in frontotemporal lobar degeneration—predicting molecular pathology

(2012) Jennifer L. Whitwell et al.   Nature Reviews Neurology

White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration

(2012) C. T. McMillan et al.   NEUROLOGY

Frontotemporal dementia due to C9ORF72 mutations: Clinical and imaging features

(2012) S. J. Sha et al.   NEUROLOGY

Neuropathological background of phenotypical variability in frontotemporal dementia

(2011) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

White Matter Damage in Frontotemporal Lobar Degeneration Spectrum

(2011) F. Agosta et al.   CEREBRAL CORTEX

Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia

(2011) Graeme C. Schwindt et al.   HUMAN BRAIN MAPPING

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

(2011) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional network disruption in the degenerative dementias

(2011) Michela Pievani et al.   LANCET NEUROLOGY

Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD

(2011) Barbara Borroni et al.   NEUROBIOLOGY OF AGING

Optimal Plasma Progranulin Cutoff Value for Predicting Null Progranulin Mutations in Neurodegenerative Diseases: A Multicenter Italian Study

(2011) Roberta Ghidoni et al.   Neurodegenerative Diseases

Altered functional connectivity in asymptomatic MAPT subjects: A comparison to bvFTD

(2011) J. L. Whitwell et al.   NEUROLOGY

Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia

(2011) E. Rogalski et al.   NEUROLOGY

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Combined Evaluation of FDG-PET and MRI Improves Detection and Differentiation of Dementia

(2011) Juergen Dukart et al.   PLoS One

Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s disease

(2010) Juan Zhou et al.   BRAIN

Caudate atrophy on MRI is a characteristic feature of FTLD-FUS

(2010) K. A. Josephs et al.   EUROPEAN JOURNAL OF NEUROLOGY

Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

(2010) H. Seelaar et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations

(2010) Jonathan D. Rohrer et al.   NEUROIMAGE

Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia

(2010) W. T. Hu et al.   NEUROLOGY

Novel CSF biomarkers for frontotemporal lobar degenerations

(2010) W. T. Hu et al.   NEUROLOGY

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

(2009) N. Finch et al.   BRAIN

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

(2009) Y. Zhang et al.   BRAIN

Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study

(2009) J. L. Whitwell et al.   BRAIN

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration

(2009) Harro Seelaar et al.   JOURNAL OF NEUROLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration

(2009) J. D. Rohrer et al.   NEUROLOGY

Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia

(2008) Gil D. Rabinovici et al.   ANNALS OF NEUROLOGY

Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia

(2008) William W. Seeley et al.   ARCHIVES OF NEUROLOGY

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration

(2008) D. Galimberti et al.   JOURNAL OF NEUROLOGY

CSF biomarkers in frontotemporal lobar degeneration with known pathology

(2008) H. Bian et al.   NEUROLOGY

Brain Magnetic Resonance Imaging Structural Changes in a Pedigree of Asymptomatic Progranulin Mutation Carriers

(2008) B. Borroni et al.   REJUVENATION RESEARCH