Microbiota in cerebrovascular disease: A key player and future therapeutic target

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Microbiota and metabolites in metabolic diseases

(2019) Patrice D. Cani   Nature Reviews Endocrinology

Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut

(2019) Xiuli Zeng et al.   Frontiers in Cellular and Infection Microbiology

Duration and life-stage of antibiotic use and risk of cardiovascular events in women

(2019) Yoriko Heianza et al.   EUROPEAN HEART JOURNAL

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

(2019) Edward S Chambers et al.   GUT

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Bacteria to alleviate metabolic syndrome

(2019) Fernando F. Anhê et al.   NATURE MEDICINE

The MSCRAMM Family of Cell-Wall-Anchored Surface Proteins of Gram-Positive Cocci

(2019) Timothy J. Foster   TRENDS IN MICROBIOLOGY

Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation

(2019) Kun Zuo et al.   GigaScience

Infection as a Stroke Trigger

(2019) Solly Sebastian et al.   STROKE

Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells

(2019) Hiroyuki Tezuka et al.   Frontiers in Immunology

Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

(2019) Tiara R. Ahmad et al.   Nature Reviews Endocrinology

The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

(2019) Matthias Prestel et al.   STROKE

Modulation of Gut Microbiota for Health by Current and Next-Generation Probiotics

(2019) Reetta Satokari   Nutrients

Global Burden of Small Vessel Disease–Related Brain Changes on MRI Predicts Cognitive and Functional Decline

(2019) Hanna Jokinen et al.   STROKE

Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome

(2018) Monica S. Spychala et al.   ANNALS OF NEUROLOGY

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

A potential relationship between gut microbes and atrial fibrillation: Trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation

(2018) Lilei Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Increased plasma trimethylamine- N -oxide is associated with incident atrial fibrillation

(2018) Gard F.T. Svingen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence

(2018) Maya L. Gosztyla et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction

(2018) Mohamed H. Noureldein et al.   MICROBIAL PATHOGENESIS

Immune quiescence in the oral mucosa is maintained by a uniquely large population of highly activated Foxp3+ regulatory T cells

(2018) Joo-Young Park et al.   Mucosal Immunology

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Microbial modulation of cardiovascular disease

(2018) J. Mark Brown et al.   NATURE REVIEWS MICROBIOLOGY

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

G.I. pros: Antimicrobial defense in the gastrointestinal tract

(2018) Lawton K. Chung et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Post-stroke inflammation—target or tool for therapy?

(2018) Kate Lykke Lambertsen et al.   ACTA NEUROPATHOLOGICA

Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

(2018) De-Cai Tian et al.   ANNALS OF NEUROLOGY

Quorum sensing inhibitors as antipathogens: biotechnological applications

(2018) Vipin Chandra Kalia et al.   BIOTECHNOLOGY ADVANCES

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Rapamycin in ischemic stroke: Old drug, new tricks?

(2018) Gina Hadley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

(2018) Kazuyuki Kasahara et al.   Nature Microbiology

Bacterial butyrate prevents atherosclerosis

(2018) Scott J. Bultman   Nature Microbiology

The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota

(2017) Christian Milani et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Beyond gut feelings: how the gut microbiota regulates blood pressure

(2017) Francine Z. Marques et al.   Nature Reviews Cardiology

Human genetic variation and the gut microbiome in disease

(2017) Andrew Brantley Hall et al.   NATURE REVIEWS GENETICS

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

Genetics of Spontaneous Intracerebral Hemorrhage

(2017) Guido J. Falcone et al.   STROKE

Procalcitonin and Midregional Proatrial Natriuretic Peptide as Biomarkers of Subclinical Cerebrovascular Damage

(2017) Mira Katan et al.   STROKE

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

(2017) Thomas W. Buford   Microbiome

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

A murine model of inflammation-induced cerebral microbleeds

(2016) Rachita K. Sumbria et al.   Journal of Neuroinflammation

Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2016) Valery L Feigin et al.   LANCET NEUROLOGY

Characterization of the human immune cell network at the gingival barrier

(2016) N Dutzan et al.   Mucosal Immunology

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Rare Variants in NOD1 Associated with Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families

(2016) Nicole D. Dueker et al.   PLoS One

Procalcitonin and Midregional Proatrial Natriuretic Peptide as Markers of Ischemic Stroke

(2016) Mira Katan et al.   STROKE

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

(2016) Masafumi Ihara et al.   STROKE

Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment

(2016) Isao Watanabe et al.   Scientific Reports

Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients

(2016) Jyoti Chhibber-Goel et al.   npj Biofilms and Microbiomes

Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study

(2016) Shuichi Tonomura et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility

(2015) Ioannis Koutsounas et al.   Expert Opinion on Drug Metabolism & Toxicology

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Oral and intestinal sweet and fat tasting: impact of receptor polymorphisms and dietary modulation for metabolic disease

(2015) N. Cvijanovic et al.   NUTRITION REVIEWS

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

(2014) Mark J. Shen et al.   CIRCULATION RESEARCH

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Maturation of the enteric mucosal innate immune system during the postnatal period

(2014) Marcus Fulde et al.   IMMUNOLOGICAL REVIEWS

Dynamics and associations of microbial community types across the human body

(2014) Tao Ding et al.   NATURE

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

The Placenta Harbors a Unique Microbiome

(2014) K. Aagaard et al.   Science Translational Medicine

Intestinal macrophages and dendritic cells: what's the difference?

(2014) Vuk Cerovic et al.   TRENDS IN IMMUNOLOGY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

The SCFA Receptor GPR43 and Energy Metabolism

(2014) Ikuo Kimura et al.   Frontiers in Endocrinology

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

Application of phylogenetic microarrays to interrogation of human microbiota

(2011) Oleg Paliy et al.   FEMS MICROBIOLOGY ECOLOGY

The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells

(2011) Jacqueline Abranches et al.   INFECTION AND IMMUNITY

Antimicrobial peptides and periodontal disease

(2011) Sven-Ulrik Gorr et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

(2011) Kazuhiko Nakano et al.   Nature Communications

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Common infections and the risk of stroke

(2010) Armin J. Grau et al.   Nature Reviews Neurology

Infectious Burden and Risk of Stroke

(2009) Mitchell S. V. Elkind   ARCHIVES OF NEUROLOGY

Molecular characterization of Streptococcus mutans strains containing the cnm gene encoding a collagen-binding adhesin

(2009) K. Nakano et al.   ARCHIVES OF ORAL BIOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE

The immune privilege of the oral mucosa

(2008) Natalija Novak et al.   TRENDS IN MOLECULAR MEDICINE