Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

(2014) Le Zhan et al.   PLoS One

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Genetic Variation inNR1H4Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

(2013) Martin Heni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Farnesoid X receptor: from medicinal chemistry to clinical applications

(2012) Stefano Fiorucci et al.   Future Medicinal Chemistry

Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

(2012) Daniel Merk et al.   Future Medicinal Chemistry

The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin

(2012) Miao Hu et al.   JOURNAL OF LIPID RESEARCH

Genetic Factors in the Pathogenesis of Cholangiocarcinoma

(2011) Christopher A. Wadsworth et al.   DIGESTIVE DISEASES

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

28 AN INTERNATIONAL STUDY EVALUATING THE FARNESOID X RECEPTOR AGONIST OBETICHOLIC ACID AS MONOTHERAPY IN PBC

(2011) K.V. Kowdley et al.   JOURNAL OF HEPATOLOGY

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

Hepatic FXR: key regulator of whole-body energy metabolism

(2011) João Soeiro Teodoro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

(2010) Tim C. M. A. Schreuder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease

(2010) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins

(2010) Miao Hu et al.   Expert Opinion on Drug Metabolism & Toxicology

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1

(2010) Henriette E. Meyer zu Schwabedissen et al.   HEPATOLOGY

2 FARNESOID-X RECEPTOR AGONISTS: A NEW CLASS OF DRUGS FOR THE TREATMENT OF PBC? AN INTERNATIONAL STUDY EVALUATING THE ADDITION OF INT-747 TO URSODEOXYCHOLIC ACID

(2010) A. Mason et al.   JOURNAL OF HEPATOLOGY

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting Farnesoid X Receptor in Hepatic and Biliary Inflammatory Diseases

(2009) Nicolas Chignard et al.   GASTROENTEROLOGY

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

(2009) Songwen Zhang et al.   JOURNAL OF HEPATOLOGY

Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy

(2009) Vincent Zimmer et al.   LIVER INTERNATIONAL

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH

Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea

(2008) Sara Balesaria et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium

(2008) Emilie D'Aldebert et al.   GASTROENTEROLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans

(2007) Peter Kovacs et al.   JOURNAL OF HEPATOLOGY