Microbial modulation of cardiovascular disease

Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery

(2017) J. Mark Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A prominent glycyl radical enzyme in human gut microbiomes metabolizestrans-4-hydroxy-l-proline

(2017) B. J. Levin et al.   SCIENCE

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

Uncovering the trimethylamine-producing bacteria of the human gut microbiota

(2017) Silke Rath et al.   Microbiome

Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men

(2016) Yan Zheng et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

(2016) Ali Ramezani et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Diet, Lifestyle, Biomarkers, Genetic Factors, and Risk of Cardiovascular Disease in the Nurses’ Health Studies

(2016) Edward Yu et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

(2016) Karolina Skagen et al.   ATHEROSCLEROSIS

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

Bile Acid Analog Intercepts Liver Fibrosis

(2016) C. Daniel De Magalhaes Filho et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Executive Summary: Heart Disease and Stroke Statistics—2016 Update

(2016) Dariush Mozaffarian et al.   CIRCULATION

Increased Trimethylamine N- Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

(2016) W. H. Wilson Tang et al.   CLINICAL CHEMISTRY

The role of short-chain fatty acid on blood pressure regulation

(2016) Junki Miyamoto et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Endotoxemia-menace, marker, or mistake?

(2016) Robert S. Munford   JOURNAL OF LEUKOCYTE BIOLOGY

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

(2016) Annika Wahlström et al.   JOURNAL OF LIPID RESEARCH

Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden

(2016) Vichai Senthong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events

(2016) Richard B. Kim et al.   KIDNEY INTERNATIONAL

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

(2016) Shuai Lu et al.   MEDICINE

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

(2016) Peter Spanogiannopoulos et al.   NATURE REVIEWS MICROBIOLOGY

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort

(2016) Vichai Senthong et al.   Journal of the American Heart Association

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

(2016) Catharina Missailidis et al.   PLoS One

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans

(2016) Elko Randrianarisoa et al.   Scientific Reports

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

(2015) J. Mark Brown et al.   Annual Review of Medicine

Microbiology Meets Big Data: The Case of Gut Microbiota–Derived Trimethylamine

(2015) Gwen Falony et al.   Annual Review of Microbiology

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

(2015) Daniel M. Mueller et al.   ATHEROSCLEROSIS

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study

(2015) Aki Mafune et al.   Clinical and Experimental Nephrology

Mechanistic Insight into TrimethylamineN-Oxide Recognition by the Marine Bacterium Ruegeria pomeroyi DSS-3

(2015) Chun-Yang Li et al.   JOURNAL OF BACTERIOLOGY

Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women

(2015) Chisato Nagata et al.   JOURNAL OF NUTRITION

Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis

(2015) Simone Filardo et al.   MEDIATORS OF INFLAMMATION

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Oral infections and cardiovascular disease

(2015) Karim El Kholy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

P. gingivalis in Periodontal Disease and Atherosclerosis – Scenes of Action for Antimicrobial Peptides and Complement

(2015) Mehak Hussain et al.   Frontiers in Immunology

In silico analyses of metagenomes from human atherosclerotic plaque samples

(2015) Suparna Mitra et al.   Microbiome

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2014) Christine Koulis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Functional role oftlyC1encoding a hemolysin-like protein fromBifidobacterium longumBBMN68 in bile tolerance

(2014) Ying Liu et al.   FEMS MICROBIOLOGY LETTERS

Trimethylamine and trimethylamine N-oxide are supplementary energy sources for a marine heterotrophic bacterium: implications for marine carbon and nitrogen cycling

(2014) Ian DEA Lidbury et al.   ISME Journal

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contributory role of gut microbiota in cardiovascular disease

(2014) W.H. Wilson Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation

(2014) S. Chen et al.   JOURNAL OF IMMUNOLOGY

Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis inApoe−/−Mice

(2014) Shunsuke Kanno et al.   JOURNAL OF IMMUNOLOGY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

(2014) Norlida M. Daud et al.   Obesity

Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study

(2014) Michael Lever et al.   PLoS One

Trimethylamine N-oxide metabolism by abundant marine heterotrophic bacteria

(2014) I. Lidbury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

(2014) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study

(2013) Camilla Pedersen et al.   APPETITE

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis

(2013) Anna M. Lundberg et al.   CARDIOVASCULAR RESEARCH

Genetic Variation inNR1H4Encoding the Bile Acid Receptor FXR Determines Fasting Glucose and Free Fatty Acid Levels in Humans

(2013) Martin Heni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults

(2013) Jelena Vulevic et al.   JOURNAL OF NUTRITION

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

(2013) E. P. Rhee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbial composition of atherosclerotic plaques

(2013) CA Calandrini et al.   ORAL DISEASES

Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine

(2013) Ivonne Wallrabenstein et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing?

(2013) Lutz Hamann et al.   Immunity & Ageing

Toll-Like Receptor 4 Deficiency Decreases Atherosclerosis But Does Not Protect Against Inflammation in Obese Low-Density Lipoprotein Receptor–Deficient Mice

(2012) Yilei Ding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining “Inflammatory” Macrophage Activation

(2012) Maria Salagianni et al.   CIRCULATION

Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response

(2012) Qian Li et al.   CURRENT BIOLOGY

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

(2012) J Fernandes et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Vitamin D Receptor Signaling Inhibits Atherosclerosis in Mice

(2012) Frances L. Szeto et al.   MOLECULAR ENDOCRINOLOGY

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of PXR decreases atherosclerosis in apoE-deficient mice

(2011) Yipeng Sui et al.   JOURNAL OF LIPID RESEARCH

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

(2011) Diego Ardissino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Toll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women

(2010) M. L. Sales et al.   AMERICAN JOURNAL OF HYPERTENSION

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2010) Peter Kanellakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dissecting thein VivoMetabolic Potential of Two Human Gut Acetogens

(2010) Federico E. Rey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

TLR2 Looks at Lipoproteins

(2009) Mirjam Schenk et al.   IMMUNITY

TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases

(2009) Carmela Rita Balistreri et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Bile salts of vertebrates: structural variation and possible evolutionary significance

(2009) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

The cell-envelope proteome of Bifidobacterium longum in an in vitro bile environment

(2009) L. Ruiz et al.   MICROBIOLOGY-SGM

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction

(2008) Arto J. Hautala et al.   ANNALS OF MEDICINE

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fifty years of advances in bile acid synthesis and metabolism

(2008) David W. Russell   JOURNAL OF LIPID RESEARCH

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY