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Title
Rapamycin in ischemic stroke: Old drug, new tricks?
Authors
Keywords
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Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 39, Issue 1, Pages 20-35
Publisher
SAGE Publications
Online
2018-10-18
DOI
10.1177/0271678x18807309
References
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Note: Only part of the references are listed.- Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
- (2018) Konark Malhotra et al. JOURNAL OF NEUROLOGY
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- (2018) Ana Antonic et al. Journal of Stroke & Cerebrovascular Diseases
- Early Blood–Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules
- (2018) Angelika Hoffmann et al. STROKE
- SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)
- (2018) Craig J. Smith et al. STROKE
- NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons
- (2018) Ana Antonic et al. Journal of Stroke & Cerebrovascular Diseases
- Neuroprotective effects of adjunctive treatments for acute stroke thrombolysis: a review of clinical evidence
- (2017) Hongxing Zhou et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system
- (2017) Yawei Zhao et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression
- (2017) Zhijun Li et al. NEUROSCIENCE
- Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia
- (2017) Oak Z. Chi et al. NEUROSCIENCE LETTERS
- Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners
- (2017) Jung Hwa Ko et al. Oncotarget
- Evolution of blood-brain-barrier permeability after acute ischemic stroke
- (2017) Zamir Merali et al. PLoS One
- Protective features of peripheral monocytes/macrophages in stroke
- (2016) Michael Gliem et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Systemic inflammation affects reperfusion following transient cerebral ischaemia
- (2016) F. Burrows et al. EXPERIMENTAL NEUROLOGY
- mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type
- (2016) Daojing Li et al. FASEB JOURNAL
- Post-stroke dysphagia: A review and design considerations for future trials
- (2016) David L Cohen et al. International Journal of Stroke
- The Translational Significance of the Neurovascular Unit
- (2016) Heather L. McConnell et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease
- (2016) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice
- (2016) Yuanyuan Ma et al. Journal of Neuroinflammation
- Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia
- (2016) Robert G. Underly et al. JOURNAL OF NEUROSCIENCE
- Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
- (2016) Sebastian I. Arriola Apelo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
- (2016) Sebastian I. Arriola Apelo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia
- (2016) O.Z. Chi et al. NEUROSCIENCE
- Effects of rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion
- (2016) Oak Z. Chi et al. NEUROSCIENCE LETTERS
- Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update
- (2016) Sarah K. McCann et al. Translational Stroke Research
- Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
- (2015) Sebastian I. Arriola Apelo et al. AGING CELL
- Neurovascular Regulation in the Ischemic Brain
- (2015) Katherine Jackman et al. ANTIOXIDANTS & REDOX SIGNALING
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE
- (2015) Zilong Zhu et al. CIRCULATION
- Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model
- (2015) Zhao Yang et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Selective modulation of microglia polarization to M2 phenotype for stroke treatment
- (2015) Cong-Yuan Xia et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
- (2015) Joyce S. Balami et al. International Journal of Stroke
- A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
- (2015) Samaneh Maysami et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate
- (2015) Sejeong Shin et al. MOLECULAR CELL
- Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen–glucose deprivation and reoxygenation
- (2015) Chun-Yu Li et al. NEUROCHEMISTRY INTERNATIONAL
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Control of macrophage metabolism and activation by mTOR and Akt signaling
- (2015) Anthony J. Covarrubias et al. SEMINARS IN IMMUNOLOGY
- Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome
- (2015) Tae-Hee Cho et al. STROKE
- A New Model of Cuprizone-Mediated Demyelination/Remyelination
- (2014) Hilary H. Sachs et al. ASN Neuro
- Autophagic neuron death in neonatal brain ischemia/hypoxia
- (2014) Yasuo Uchiyama et al. Autophagy
- Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke
- (2014) Qiang Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2014) Hugo You-Hsien Lin et al. BMC IMMUNOLOGY
- Autophagy suppression by exercise pretreatment and p38 inhibition is neuroprotective in cerebral ischemia
- (2014) Li Zhang et al. BRAIN RESEARCH
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- (2014) Yoko Takahashi et al. BRAIN RESEARCH
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- (2014) Zhongwu Liu et al. GLIA
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- (2013) Ruchi Rastogi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Kirtiman Srivastava et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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- (2013) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010
- (2013) Valery L Feigin et al. LANCET
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- (2013) Luke A. J. O'Neill et al. NATURE
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- (2012) A. M. McInturff et al. BLOOD
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- (2012) Dieter A. Kubli et al. CIRCULATION RESEARCH
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- Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation
- (2012) Esther Steiner et al. GLIA
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- (2012) Jens Minnerup et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2012) Lele Yin et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
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- (2012) Turgay Dalkara et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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- (2012) Yasemin Gursoy-Ozdemir et al. JOURNAL OF NEUROCHEMISTRY
- The effect of stroke on immune function
- (2012) Roberta Brambilla et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation
- (2012) Thomas H. Sanderson et al. MOLECULAR NEUROBIOLOGY
- Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in Rats
- (2012) Li Gao et al. PLoS One
- Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats
- (2011) Anjali Chauhan et al. BEHAVIOURAL BRAIN RESEARCH
- S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation
- (2011) J. E. Aslan et al. BLOOD
- Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats
- (2011) Wenjun Yan et al. BRAIN RESEARCH
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- (2011) Vittoria Zinzalla et al. CELL
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- (2011) Won Jun Oh et al. CELL CYCLE
- Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia
- (2011) Yoshiki Hase et al. EXPERIMENTAL NEUROLOGY
- Cellular Mechanisms of Neurovascular Damage and Repair After Stroke
- (2011) Ken Arai et al. JOURNAL OF CHILD NEUROLOGY
- Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy
- (2011) Jin-Ye Wang et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Cerebral blood flow alteration in neuroprotection following cerebral ischaemia
- (2011) Brad A. Sutherland et al. JOURNAL OF PHYSIOLOGY-LONDON
- Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
- (2010) Ai-Ping Qin et al. Autophagy
- Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning
- (2010) Rui Sheng et al. Autophagy
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- (2010) Lunhua Liu et al. DEVELOPMENTAL CELL
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity
- (2010) Lei Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy gone awry in neurodegenerative diseases
- (2010) Esther Wong et al. NATURE NEUROSCIENCE
- FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma
- (2010) V. E. Kwitkowski et al. ONCOLOGIST
- Small GTPase RhoA and Its Effector Rho Kinase Mediate Oxygen Glucose Deprivation-Evoked In Vitro Cerebral Barrier Dysfunction
- (2010) Claire Allen et al. STROKE
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
- (2009) Alyson K. Baker et al. MOLECULAR IMMUNOLOGY
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- (2009) Muge Yemisci et al. NATURE MEDICINE
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- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- Assessing Reperfusion and Recanalization as Markers of Clinical Outcomes After Intravenous Thrombolysis in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)
- (2009) Deidre A. De Silva et al. STROKE
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- (2009) Livia S. Machado et al. STROKE
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- (2009) Bruno P. Soares et al. STROKE
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- (2008) T. Tomsick et al. AMERICAN JOURNAL OF NEURORADIOLOGY
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- (2008) Masato Koike et al. AMERICAN JOURNAL OF PATHOLOGY
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- A new penumbra: transitioning from injury into repair after stroke
- (2008) Eng H Lo NATURE MEDICINE
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- (2008) Karin E. Sandoval et al. NEUROBIOLOGY OF DISEASE
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- (2008) D. Strbian et al. NEUROSCIENCE
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- (2008) Malcolm R. Macleod et al. STROKE
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- (2008) B. P. Soares et al. STROKE
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