Journal
CELL TRANSPLANTATION
Volume 28, Issue 5, Pages 529-537Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0963689718794864
Keywords
cord blood; induced pluripotent stem cell; cartilage; chondrogenesis; tissue regeneration; differentiation
Funding
- Korea Healthcare Technology R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [HI16C2177, H18C1178]
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Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in cartilage regeneration. The abilities of these cells to undergo chondrogenic differentiation are also described. Finally, the technical challenges of articular cartilage regeneration and future directions are discussed.
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