Emerging myelin repair agents in preclinical and early clinical development for the treatment of multiple sclerosis

Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis

(2020) Andrew P. Robinson et al.   Scientific Reports

Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis

(2019) Carlijn R. Hooijmans et al.   Scientific Reports

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors

(2019) Kelsey A. Rankin et al.   JOURNAL OF NEUROSCIENCE

Remyelination in multiple sclerosis

(2019) David Kremer et al.   CURRENT OPINION IN NEUROLOGY

Transcriptional control of myelination and remyelination

(2019) Elisabeth Sock et al.   GLIA

Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial

(2019) Diego Cadavid et al.   LANCET NEUROLOGY

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

(2019) Simon Faissner et al.   NATURE REVIEWS DRUG DISCOVERY

Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis

(2019) Jaime Gonzalez Cardona et al.   PLoS One

Evoked potentials as a biomarker of remyelination

(2019) Moones Heidari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Sclerosis Pathology

(2018) Hans Lassmann   Cold Spring Harbor Perspectives in Medicine

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α

(2018) Samuel K. Jensen et al.   Cell Reports

Predictors of response to opicinumab in acute optic neuritis

(2018) Diego Cadavid et al.   Annals of Clinical and Translational Neurology

Current advancements in promoting remyelination in multiple sclerosis

(2018) David Kremer et al.   Multiple Sclerosis Journal

The adult oligodendrocyte can participate in remyelination

(2018) Ian D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury

(2017) Robert B Shultz et al.   Journal of Neural Engineering

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

Remyelination therapies: a new direction and challenge in multiple sclerosis

(2017) Jason R. Plemel et al.   NATURE REVIEWS DRUG DISCOVERY

Achievements and obstacles of remyelinating therapies in multiple sclerosis

(2017) Martin Stangel et al.   Nature Reviews Neurology

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination

(2017) Ariana P. Mullin et al.   NEUROBIOLOGY OF DISEASE

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

(2017) Yongfeng Chen et al.   PLoS One

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination

(2016) Abbe H. Crawford et al.   AMERICAN JOURNAL OF PATHOLOGY

Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study

(2016) Caryl J. Schwartzbach et al.   JOURNAL OF NEUROLOGY

Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice

(2016) Adib Zendedel et al.   METABOLIC BRAIN DISEASE

Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules

(2016) K. Magalon et al.   NEUROPHARMACOLOGY

Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial—study protocol

(2016) Ricarda Diem et al.   BMJ Open

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease

(2015) Bharath Wootla et al.   MOLECULAR NEUROBIOLOGY

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

(2015) Ernest S. Smith et al.   NEUROBIOLOGY OF DISEASE

Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination

(2015) Zhifang Li et al.   Neuroscience Bulletin

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Neuroprotective effects of testosterone treatment in men with multiple sclerosis

(2014) Florian Kurth et al.   NeuroImage-Clinical

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

(2013) David M. Wilson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

(2013) Rashad Hussain et al.   BRAIN

The Safety, Tolerability, Pharmacokinetics and Cognitive Effects of GSK239512, a Selective Histamine H3 Receptor Antagonist in Patients with Mild to Moderate Alzheimer’s Disease: A Preliminary Investigation

(2013) Pradeep J. Nathan et al.   Current Alzheimer Research

A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis

(2012) Kurt-Wolfram Sühs et al.   ANNALS OF NEUROLOGY

Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination

(2012) Yanbo Zhang et al.   SCHIZOPHRENIA RESEARCH

Olesoxime accelerates myelination and promotes repair in models of demyelination

(2011) Karine Magalon et al.   ANNALS OF NEUROLOGY

Erythropoietin promotes oligodendrogenesis and myelin repair following lysolecithin-induced injury in spinal cord slice culture

(2011) Yun Kyung Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of immune semaphorins in multiple sclerosis

(2011) Tatsusada Okuno et al.   FEBS LETTERS

Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes

(2010) J. Watzlawik et al.   GLIA

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

(2009) Sha Mi et al.   ANNALS OF NEUROLOGY

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Extensive remyelination of the CNS leads to functional recovery

(2009) I. D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone

(2008) Stefan M Gold et al.   Journal of Neuroinflammation

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

(2008) L.-A. Harsan et al.   JOURNAL OF NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE