Current advancements in promoting remyelination in multiple sclerosis

Teriflunomide promotes oligodendroglial differentiation and myelination

(2018) Peter Göttle et al.   Journal of Neuroinflammation

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

(2018) Ivana Bjelobaba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

(2017) Bernhard Josef Rüther et al.   GLIA

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

(2016) Antonietta Gentile et al.   Journal of Neuroinflammation

Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study

(2016) Caryl J. Schwartzbach et al.   JOURNAL OF NEUROLOGY

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination

(2016) Feng Mei et al.   JOURNAL OF NEUROSCIENCE

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Long-term safety and efficacy of teriflunomide

(2016) Paul O'Connor et al.   NEUROLOGY

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

(2016) Frédéric Sedel et al.   NEUROPHARMACOLOGY

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Promoting remyelination in multiple sclerosis: Current drugs and future prospects

(2015) David Kremer et al.   Multiple Sclerosis Journal

A Phase II study of a histamine H3 receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy

(2015) L. Fredrik Jarskog et al.   SCHIZOPHRENIA RESEARCH

Promoting remyelination in multiple sclerosis: Current drugs and future prospects

(2015) David Kremer et al.   Multiple Sclerosis Journal

A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H3 Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease

(2014) Richard Grove et al.   Current Alzheimer Research

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial

(2014) Christian Confavreux et al.   LANCET NEUROLOGY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Teriflunomide for the treatment of multiple sclerosis

(2013) Clemens Warnke et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic

(2013) Sha Mi et al.   CNS DRUGS

Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice

(2012) Xiaoying Bi et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

The complex world of oligodendroglial differentiation inhibitors

(2011) David Kremer et al.   ANNALS OF NEUROLOGY

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

The role of immune semaphorins in multiple sclerosis

(2011) Tatsusada Okuno et al.   FEBS LETTERS

Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis

(2011) Vanja Tepavčević et al.   JOURNAL OF CLINICAL INVESTIGATION

Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

(2011) Per Soelberg Sorensen et al.   LANCET NEUROLOGY

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic disruption of the WNT/ß-catenin signaling pathway in human cancers

(2010) Ying Ying et al.   Epigenetics

Overcoming remyelination failure in multiple sclerosis and other myelin disorders

(2010) Stephen P.J. Fancy et al.   EXPERIMENTAL NEUROLOGY

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

(2009) Hervé Perron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2009) T. Okuno et al.   JOURNAL OF IMMUNOLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

The role of SVZ-derived neural precursors in demyelinating diseases: From animal models to multiple sclerosis

(2007) B. Nait-Oumesmar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES