The Recombinant BCG ΔureC::hlyVaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation

The BCG replacement vaccine VPM1002: from drawing board to clinical trial

(2014) Stefan HE Kaufmann et al.   Expert Review of Vaccines

Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine's Superior Protection Against Tuberculosis

(2014) Alexis Vogelzang et al.   JOURNAL OF INFECTIOUS DISEASES

Recent advances towards tuberculosis control: vaccines and biomarkers

(2014) J. Weiner et al.   JOURNAL OF INTERNAL MEDICINE

AhR sensing of bacterial pigments regulates antibacterial defence

(2014) Pedro Moura-Alves et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Autophagy in Tuberculosis

(2014) V. Deretic   Cold Spring Harbor Perspectives in Medicine

Receptor-mediated recognition of mycobacterial pathogens

(2013) Kate E. Killick et al.   CELLULAR MICROBIOLOGY

Inflammation in tuberculosis: interactions, imbalances and interventions

(2013) Stefan HE Kaufmann et al.   CURRENT OPINION IN IMMUNOLOGY

Tuberculosis vaccines: Time to think about the next generation

(2013) Stefan H.E. Kaufmann   SEMINARS IN IMMUNOLOGY

Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial

(2013) Leander Grode et al.   VACCINE

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

The recombinant tuberculosis vaccine rBCG ΔureC::hly+ induces apoptotic vesicles for improved priming of CD4+ and CD8+ T cells

(2012) Maura Farinacci et al.   VACCINE

Mycobacterium tuberculosis and the intimate discourse of a chronic infection

(2011) David G. Russell   IMMUNOLOGICAL REVIEWS

Recombinant BCG ΔureC hly+ Induces Superior Protection Over Parental BCG by Stimulating a Balanced Combination of Type 1 and Type 17 Cytokine Responses

(2011) Christiane Desel et al.   JOURNAL OF INFECTIOUS DISEASES

Role of innate cytokines in mycobacterial infection

(2011) A M Cooper et al.   Mucosal Immunology

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

(2010) K. Tsuchiya et al.   JOURNAL OF IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance

(2008) Jean Pieters   Cell Host & Microbe

Human macrophage host defense against Mycobacterium tuberculosis

(2008) Philip T Liu et al.   CURRENT OPINION IN IMMUNOLOGY

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY