Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

Autophagy and acute pancreatitis: A novel autophagy theory for trypsinogen activation

(2014) Masaki Ohmuraya et al.   Autophagy

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

(2012) Timo D. Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis

(2011) Stephen J. Pandol et al.   DIGESTIVE DISEASES

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice

(2011) David A. Hess et al.   GASTROENTEROLOGY

Digesting New Information About the Role of Trypsin in Pancreatitis

(2011) Baoan Ji et al.   GASTROENTEROLOGY

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

(2011) Mark J. Czaja   GASTROENTEROLOGY

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis

(2011) S. Gaiser et al.   GUT

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

(2011) Takashi Itoh et al.   JOURNAL OF CELL BIOLOGY

The Complex Exocrine–Endocrine Relationship and Secondary Diabetes in Exocrine Pancreatic Disorders

(2011) Nancy Chen et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Molecular biology of pancreatic cancer

(2011) Miroslav Zavoral   WORLD JOURNAL OF GASTROENTEROLOGY

Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis

(2010) Risheng Ye et al.   AMERICAN JOURNAL OF PATHOLOGY

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage

(2010) Aurelia Lugea et al.   GASTROENTEROLOGY

MutantCHUKand Severe Fetal Encasement Malformation

(2010) Jenni Lahtela et al.   NEW ENGLAND JOURNAL OF MEDICINE

IKK-dependent, NF-κB-independent control of autophagic gene expression

(2010) W C Comb et al.   ONCOGENE

Selective degradation of p62 by autophagy

(2010) Yoshinobu Ichimura et al.   Seminars in Immunopathology

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Chronic Pancreatitis: Genetics and Pathogenesis

(2009) Jian-Min Chen et al.   Annual Review of Genomics and Human Genetics

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice

(2009) Thomas Wartmann et al.   GASTROENTEROLOGY

Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

(2009) R. Szmola et al.   GUT

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism

(2009) Éva Kereszturi et al.   HUMAN MUTATION

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

(2009) Olga A. Mareninova et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

IKKα Is Required to Maintain Skin Homeostasis and Prevent Skin Cancer

(2008) Bigang Liu et al.   CANCER CELL

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

(2008) Daisuke Hashimoto et al.   JOURNAL OF CELL BIOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Endoplasmic reticulum stress and the pancreatic acinar cell

(2008) Constanze H Kubisch et al.   Expert Review of Gastroenterology & Hepatology