The PYHIN protein family as mediators of host defenses

Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection

(2014) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fc  Receptor (Fc RIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein

(2011) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Interferon-Inducible Protein 16: Insight into the Interaction with Tumor Suppressor p53

(2011) Jack C.C. Liao et al.   STRUCTURE

Genomes in Conflict: Maintaining Genome Integrity During Virus Infection

(2010) Matthew D. Weitzman et al.   Annual Review of Microbiology

Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

(2010) S. Costa et al.   BRITISH JOURNAL OF DERMATOLOGY

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus and increased risk to develop B cell malignancies: Role of the p200-family proteins

(2010) Sudhakar Veeranki et al.   IMMUNOLOGY LETTERS

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus

(2010) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and a Loss of Virulence

(2010) T. K. Ulland et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2

(2010) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

(2010) I. M. Cristea et al.   JOURNAL OF VIROLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

RPA nucleic acid-binding properties of IFI16-HIN200

(2008) Hongyue Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE