BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs

The application of big data to cardiovascular disease: paths to precision medicine

(2020) Jane A. Leopold et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

(2020) Emily J. Faivre et al.   NATURE

Make your best BET: The emerging role of BET inhibitor treatment in malignant tumors

(2020) Oliver Bechter et al.   PHARMACOLOGY & THERAPEUTICS

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

(2019) Marios K. Georgakis et al.   CIRCULATION

Endothelial to Mesenchymal Transition in Cardiovascular Disease

(2019) Jason C. Kovacic et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats

(2019) Jianle Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

(2019) Anup Dey et al.   EMBO JOURNAL

Inflammation and fibrosis in murine models of heart failure

(2019) Lucas Bacmeister et al.   BASIC RESEARCH IN CARDIOLOGY

How Might Bromodomain and Extra-Terminal (BET) Inhibitors Operate in Cardiovascular Disease?

(2019) C. Mary Schooling et al.   American Journal of Cardiovascular Drugs

BET in Pulmonary Arterial Hypertension: Exploration of BET Inhibitors to Reverse Vascular Remodeling

(2019) Zhiyu Dai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetics in Human Obesity and Type 2 Diabetes

(2019) Charlotte Ling et al.   Cell Metabolism

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

(2019) Leighton Core et al.   GENES & DEVELOPMENT

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

(2019) Shweta Joshi et al.   MOLECULAR CANCER THERAPEUTICS

BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

(2019) Judith Sánchez-Ventura et al.   Journal of Neuroinflammation

Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D

(2019) Michael I. Robson et al.   MOLECULAR CELL

Bromodomains: a new target class for drug development

(2019) Andrea G. Cochran et al.   NATURE REVIEWS DRUG DISCOVERY

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production

(2019) Hunter R. Gibbons et al.   Scientific Reports

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

(2019) Laura M. Tsujikawa et al.   Clinical Epigenetics

A systematic review of smoking-related epigenetic alterations

(2019) Gagandeep Kaur et al.   ARCHIVES OF TOXICOLOGY

Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension

(2019) Mohammad AbdulHai Siddique et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation

(2019) Mengxue Zhang et al.   CELLULAR SIGNALLING

Epigenetics and vascular diseases

(2019) Matthew S. Stratton et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epigenetic Modification in Coronary Atherosclerosis

(2019) Barbara Rizzacasa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells

(2019) Shino Murakami et al.   MOLECULAR CANCER RESEARCH

Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial

(2019) Kausik K. Ray et al.   AMERICAN HEART JOURNAL

Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction

(2019) Hannah R. Elliott et al.   DIABETOLOGIA

Evidence of epigenetic alterations in thrombosis and coagulation: A systematic review

(2019) M.D. Patsouras et al.   JOURNAL OF AUTOIMMUNITY

The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1β eRNA and mRNA transcription in mouse melanoma and macrophage cell lines

(2019) Soon-Duck Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing

(2019) Sheetal Uppal et al.   Cell Reports

A patent review of BRD4 inhibitors (2013-2019)

(2019) Tian Lu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia

(2018) Kelly M. DeMars et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters

(2018) Bowen Wang et al.   BIOMATERIALS

Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression

(2018) Zhongyuan Gao et al.   CANCER BIOLOGY & THERAPY

JQ-1 Inhibits Colon Cancer Proliferation via Suppressing Wnt/β-Catenin Signaling and miR-21

(2018) Yan Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Disrupting Acetyl-lysine Interactions: Recent Advance in the Development of BET Inhibitors

(2018) Fa Zhang et al.   CURRENT DRUG TARGETS

Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

(2018) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

(2018) Erik Abner et al.   JOURNAL OF VIROLOGY

Born to run: control of transcription elongation by RNA polymerase II

(2018) Fei Xavier Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

(2018) Andrew P. Feinberg   NEW ENGLAND JOURNAL OF MEDICINE

BRD4 facilitates replication stress-induced DNA damage response

(2018) Jingwen Zhang et al.   ONCOGENE

BET bromodomain proteins regulate enhancer function during adipogenesis

(2018) Jonathan D. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

(2018) Bing Tian et al.   Cell Reports

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

(2018) Anne Gegonne et al.   Cell Reports

Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

(2018) Maria A Sacta et al.   eLife

Bromodomain Drug Discovery – the Past, the Present, and the Future

(2018) Mehrosh Pervaiz et al.   CHEMICAL RECORD

Breakthrough Therapy Designation for New Drugs

(2018) Edward J. Benz   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells

(2018) Kotaro Hishiki et al.   LEUKEMIA RESEARCH

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Inhibition of BRD4 attenuates transverse aortic constriction- and TGF-β-induced endothelial-mesenchymal transition and cardiac fibrosis

(2018) Shuai Song et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

(2017) Lei Zhao et al.   Journal of Neuroinflammation

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

(2017) D T Saenz et al.   LEUKEMIA

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

(2017) B Sun et al.   LEUKEMIA

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

(2017) Georg E. Winter et al.   MOLECULAR CELL

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

The interplay of epigenetic marks during stem cell differentiation and development

(2017) Yaser Atlasi et al.   NATURE REVIEWS GENETICS

BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

(2017) Kalung Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brd4 modulates the innate immune response through Mnk2–eIF4E pathway-dependent translational control of IκBα

(2017) Yan Bao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

(2017) Qiming Duan et al.   Science Translational Medicine

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

(2017) Sadhan Das et al.   Nature Communications

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

(2017) Jiahuan Chen et al.   Nature Communications

BET Proteins as Targets for Anticancer Treatment

(2017) Anastasios Stathis et al.   Cancer Discovery

BET inhibitors as novel therapeutic agents in breast cancer

(2017) Alberto Ocaña et al.   Oncotarget

Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages

(2017) Wenhui Ren et al.   Scientific Reports

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

(2017) Simon J. Hogg et al.   Cell Reports

Targeting Cancer Cells with BET Bromodomain Inhibitors

(2017) Yali Xu et al.   Cold Spring Harbor Perspectives in Medicine

Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer

(2016) Sophia Pinz et al.   BMC MOLECULAR BIOLOGY

A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

(2016) Michele Ceribelli et al.   CANCER CELL

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Epigenetic Changes in Diabetes and Cardiovascular Risk

(2016) Samuel T. Keating et al.   CIRCULATION RESEARCH

Does intrauterine exposure to hypercholesterolemia adversely affect familial hypercholesterolemia phenotype?

(2016) Martin P. Bogsrud et al.   CURRENT OPINION IN LIPIDOLOGY

Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE −/− mice

(2016) Qiong Duan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Molecular mechanisms of HIV latency

(2016) Daniele C. Cary et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

(2016) Lars Tögel et al.   MOLECULAR CANCER THERAPEUTICS

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

(2016) Ballachanda N Devaiah et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer

(2016) L L da Motta et al.   ONCOGENE

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects

(2016) Hidayatullah Munshi et al.   OncoTargets and Therapy

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

(2016) Ballachanda N Devaiah et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS

(2016) Mingcheng Huang et al.   Scientific Reports

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

(2015) Michael Zengerle et al.   ACS Chemical Biology

Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial

(2015) Stephen J. Nicholls et al.   American Journal of Cardiovascular Drugs

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

(2015) Rachel L. Clifford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

(2015) Delphine Gomez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

(2015) Y. Sun et al.   BLOOD

Bromodomain-Containing Protein 4Novelty and Significance

(2015) Jolyane Meloche et al.   CIRCULATION RESEARCH

Small-Molecule BET Inhibitors in Clinical and Preclinical Development and Their Therapeutic Potential

(2015) Lei Yu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Epigenetic modifications of the immune system in health and disease

(2015) Yuuki Obata et al.   IMMUNOLOGY AND CELL BIOLOGY

BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle

(2015) Mark M. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

(2015) Philipp Rathert et al.   NATURE

BET inhibitor resistance emerges from leukaemia stem cells

(2015) Chun Yew Fong et al.   NATURE

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

Structure of an RNA polymerase II preinitiation complex

(2015) Kenji Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression

(2015) Gong-Quan Li et al.   Oncotarget

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

(2015) Ioanna Ledaki et al.   Oncotarget

Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1

(2015) Amitabh Das et al.   Scientific Reports

Bromodomain Blockade for Intimal Hyperplasia — A Good BET?

(2015) Allison C. Ostriker et al.   EBioMedicine

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries

(2015) Bowen Wang et al.   EBioMedicine

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice

(2014) Ravi Jahagirdar et al.   ATHEROSCLEROSIS

Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression

(2014) Mar Gacias et al.   CHEMISTRY & BIOLOGY

BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes

(2014) Chun Hin Chan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bromodomain and Extraterminal Proteins Suppress NF-E2-Related Factor 2-Mediated Antioxidant Gene Expression

(2014) C. Michaeloudes et al.   JOURNAL OF IMMUNOLOGY

The Epigenetic Regulator I-BET151 Induces BIM-Dependent Apoptosis and Cell Cycle Arrest of Human Melanoma Cells

(2014) Stuart J. Gallagher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

(2014) Romain Gosmini et al.   JOURNAL OF MEDICINAL CHEMISTRY

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

The genetic code

(2014) J. Marshall   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

(2014) Jessica E. Bolden et al.   Cell Reports

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

(2014) Raffaella Di Micco et al.   Cell Reports

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

(2013) A. Chaidos et al.   BLOOD

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

BET bromodomain inhibition suppresses TH17-mediated pathology

(2013) Deanna A. Mele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

(2013) S. Picaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bromodomain interaction module

(2012) Panagis Filippakopoulos et al.   FEBS LETTERS

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

(2012) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

(2012) B. N. Devaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives

(2012) Matthew M. Croken et al.   TRENDS IN PARASITOLOGY

Vascular Inflammation and Repair

(2011) Teruo Inoue et al.   JACC-Cardiovascular Interventions

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

(2011) Sebastian Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease

(2011) Stephen J. Nicholls et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RVX-208

(2010) Dana Bailey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

(2009) Jeanne Morinière et al.   NATURE