BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Macrophage precursor cells from the left atrial appendage of the heart spontaneously reprogram into a C-kit+/CD45− stem cell-like phenotype

(2016) Jussi V. Leinonen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Roche bets on bromodomains

(2016) Eva von Schaper   NATURE BIOTECHNOLOGY

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

(2016) Dong U. Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

(2016) Matthew S. Stratton et al.   Cell Reports

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis -Regulatory Elements

(2016) Anand S. Bhagwat et al.   Cell Reports

Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study

(2016) Céline Berthon et al.   Lancet Haematology

miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2015) Xiaojun Liu et al.   Cell Metabolism

Cardio-Oncology

(2015) Andrew M. Bellinger et al.   CIRCULATION

Innate Immunity and the Failing Heart

(2015) Douglas L. Mann   CIRCULATION RESEARCH

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

(2015) Chen Shen et al.   MOLECULAR CELL

BRD4 is a novel therapeutic target for liver fibrosis

(2015) Ning Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes

(2015) Huanyu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4/TRAF6/NF-κB pathway

(2015) YANGLI SUN et al.   Experimental and Therapeutic Medicine

Transcriptional Landscape of Cardiomyocyte Maturation

(2015) Hideki Uosaki et al.   Cell Reports

Epigenetic Mechanisms in Heart Failure Pathogenesis

(2014) Thomas G. Di Salvo et al.   Circulation-Heart Failure

BET-ting on chromatin-based therapeutics for heart failure

(2014) Saptarsi M. Haldar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

(2014) Lei Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs

(2014) S. J. Matkovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

(2014) Jessica E. Bolden et al.   Cell Reports

Genetics and Disease of Ventricular Muscle

(2014) D. Fatkin et al.   Cold Spring Harbor Perspectives in Medicine

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

(2013) Bjoern Chapuy et al.   CANCER CELL

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

(2013) Bernhard Unsöld et al.   CARDIOVASCULAR RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Transcriptional Regulation and Its Misregulation in Disease

(2013) Tong Ihn Lee et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Research Advances in Heart Failure

(2013) Eugene Braunwald   CIRCULATION RESEARCH

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

(2013) Jessica I. Spiltoir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Small-Molecule Inhibition of BRDT for Male Contraception

(2012) Martin M. Matzuk et al.   CELL

Executive Summary: Heart Disease and Stroke Statistics—2012 Update

(2012) et al.   CIRCULATION

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Epigenetic Readers in Cancer

(2012) Mark A. Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy

(2012) Hong Ki Song et al.   PLoS One

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Left Ventricular Remodeling in Heart Failure

(2011) Marvin A. Konstam et al.   JACC-Cardiovascular Imaging

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Klf15 Deficiency Is a Molecular Link Between Heart Failure and Aortic Aneurysm Formation

(2010) S. M. Haldar et al.   Science Translational Medicine

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE