CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells

(2014) T. Tanabe et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells

(2014) Younis M. Khan et al.   PLoS One

Differences in Specificity and Selectivity Between CBP and p300 Acetylation of Histone H3 and H3/H4

(2013) Ryan A. Henry et al.   BIOCHEMISTRY

PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

(2013) S. Picaud et al.   CANCER RESEARCH

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes

(2013) S.-M. Ho et al.   ILAR JOURNAL

BET bromodomain inhibition suppresses TH17-mediated pathology

(2013) Deanna A. Mele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer

(2012) Xavier Tekpli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Abnormal Histone Methylation Is Responsible for Increased Vascular Endothelial Growth Factor 165a Secretion from Airway Smooth Muscle Cells in Asthma

(2012) R. L. Clifford et al.   JOURNAL OF IMMUNOLOGY

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas

(2011) Jan Dimberg et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer

(2011) Anne-Marie Baird et al.   PLoS One

LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes

(2010) Tiziana Angrisano et al.   BMC MICROBIOLOGY

Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children

(2010) C. M. H. H. T. Robroeks et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Airway smooth muscle proliferation and survival is not modulated by mast cells

(2010) D. Kaur et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Neutrophils in chronic inflammatory airway diseases: can we target them and how?

(2010) Y. Gernez et al.   EUROPEAN RESPIRATORY JOURNAL

Epigenetic regulation of cancer growth by histone demethylases

(2010) Soyoung Lim et al.   INTERNATIONAL JOURNAL OF CANCER

Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704

(2010) Ananya Manuyakorn et al.   JOURNAL OF CLINICAL ONCOLOGY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Global Initiative for Asthma (GINA) guidelines: 15 years of application

(2009) Claus Kroegel   Expert Review of Clinical Immunology

Human Airway Smooth Muscle Cells from Asthmatic Individuals Have CXCL8 Hypersecretion Due to Increased NF- B p65, C/EBP , and RNA Polymerase II Binding to the CXCL8 Promoter

(2009) A. E. John et al.   JOURNAL OF IMMUNOLOGY

Oxidative Stress CausesIL8Promoter Hyperacetylation in Cystic Fibrosis Airway Cell Models

(2008) Toni R. Bartling et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CpG dinucleotides and the mutation rate of non-CpG DNA

(2008) J.-C. Walser et al.   GENOME RESEARCH