Ubiquitin chromatin remodelling after DNA damage is associated with the expression of key cancer genes and pathways

Writing Histone Monoubiquitination in Human Malignancy—The Role of RING Finger E3 Ubiquitin Ligases

(2019) Deborah J. Marsh et al.   Genes

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

(2018) Chunwan Lu et al.   BMC CANCER

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

(2018) Mikkel Staberg et al.   Molecular Oncology

Overexpression of xeroderma pigmentosum group�C decreases the chemotherapeutic sensitivity of colorectal carcinoma cells to cisplatin

(2018) Yi Zhang et al.   Oncology Letters

C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

(2018) Dan Liu et al.   Nature Communications

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

(2018) Tibor van Welsem et al.   NUCLEIC ACIDS RESEARCH

Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer

(2018) Jagmohan Hooda et al.   CANCER RESEARCH

Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy

(2017) Rogerio Castilho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells

(2017) Ercan Cacan   JOURNAL OF CHEMOTHERAPY

Targeting HDAC3, a new partner protein of AKT in the reversal of chemoresistance in acute myeloid leukemia via DNA damage response

(2017) J Long et al.   LEUKEMIA

Sharing the SAGA

(2017) Dominique Helmlinger et al.   TRENDS IN BIOCHEMICAL SCIENCES

KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

(2017) Jiong Li et al.   Nature Communications

Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity

(2017) Markus Kaller et al.   Oncotarget

Novel anti-EPHA2 antibody, DS-8895a for cancer treatment

(2016) Jun Hasegawa et al.   CANCER BIOLOGY & THERAPY

The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer

(2016) Kristie-Ann Dickson et al.   HUMAN MOLECULAR GENETICS

Epigenome Maintenance in Response to DNA Damage

(2016) Juliette Dabin et al.   MOLECULAR CELL

Structural and biochemical analyses of monoubiquitinated human histones H2B and H4

(2016) Shinichi Machida et al.   Open Biology

The state-of-play and future of platin drugs

(2015) M. Apps et al.   ENDOCRINE-RELATED CANCER

Tetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers

(2015) Kyu Kwang Kim et al.   Scientific Reports

Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors

(2014) Betty K Samulitis et al.   CANCER BIOLOGY & THERAPY

Histone H2B monoubiquitination: roles to play in human malignancy

(2014) Alexander J Cole et al.   ENDOCRINE-RELATED CANCER

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

(2014) Gilad Fuchs et al.   GENOME RESEARCH

Histones and Their Modifications in Ovarian Cancer – Drivers of Disease and Therapeutic Targets

(2014) Deborah J. Marsh et al.   Frontiers in Oncology

Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research

(2013) Michael S. Anglesio et al.   PLoS One

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Systematic Identification of Proteins Binding to Chromatin-Embedded Ubiquitylated H2B Reveals Recruitment of SWI/SNF to Regulate Transcription

(2013) Efrat Shema-Yaacoby et al.   Cell Reports

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin

(2012) Sigurd Braun et al.   EMBO REPORTS

H2B monoubiquitylation is a 5′-enriched active transcription mark and correlates with exon–intron structure in human cells

(2012) Inkyung Jung et al.   GENOME RESEARCH

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells

(2012) N Chapman-Rothe et al.   ONCOGENE

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Histone Methyltransferase MLL1 Regulates MDR1 Transcription and Chemoresistance

(2010) H. Huo et al.   CANCER RESEARCH

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

(2010) D. Rossetto et al.   CLINICAL CANCER RESEARCH

The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes

(2010) Edwin Smith et al.   MOLECULAR CELL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

(2008) M. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

Deciphering histone 2A deubiquitination

(2008) Michael J Clague et al.   GENOME BIOLOGY