Review
Oncology
Bayley G. Matthews, Nikola A. Bowden, Michelle W. Wong-Brown
Summary: High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer, with a stagnant overall survival rate over the past three decades. Chemoresistance remains a major challenge in treating HGSOC, and may be driven by epigenetic modifications. Identifying epigenetic changes in chemoresistant HGSOC allows for the development of targeted therapies to improve outcomes.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Biochemistry & Molecular Biology
Rieke Schroeder, Anna-Lena Illert, Thalia Erbes, Christian Flotho, Michael Luebbert, Jesus Duque-Afonso
Summary: Breast cancer presents challenges in early diagnosis and treatment, with epigenetics offering potential solutions. Differential DNA methylation and expression of histone-modifying enzymes can differentiate breast cancer cells, while new technologies like detection of circulating nucleic acids are emerging for early detection. Preclinical and clinical studies show therapeutic benefits of epigenetically active drugs, especially when combined with conventional therapies. Integration of epigenetic substances into established breast cancer therapy protocols holds promise for future clinical applications.
Article
Biochemistry & Molecular Biology
Jin Song, Julia A. VanBuskirk, Shannath L. Merbs
Summary: This study reveals an important role of epigenetic regulation in controlling opsin expression, and demonstrates this through experiments using epigenetic modifiers in cell cultures and mouse retinal explants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bibiana Torok, Csilla Lea Fazekas, Adrienn Szabo, Dora Zelena
Summary: Vasopressin, acting through V2, V1a, and V1b receptors, regulates kidney water resorption, blood pressure, stress-axis, social behavior, and memory. Its implication in depression and schizophrenia may involve epigenetic changes such as DNA methylation, histone modification, and micro RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Review
Oncology
Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang, Xipeng Wang
Summary: Ovarian cancer is associated with activation of oncogenes and inactivation of tumor suppressor genes, with epigenetic processes playing a key role in tumorigenesis. MicroRNA and long non-coding RNA are promising molecular markers for precision medicine in OC. Clinical application of epigenetic approaches is currently limited by hurdles such as heterogeneity of OC and insufficient sample sizes, but holds promise for future clinical investigation into diagnosis, treatment, and prognosis.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Chaithanya Ganji, Batoul Farran
Summary: This review focuses on dysregulated genes associated with epigenetic mechanisms in pancreatic cancer progression and resistance, as well as current clinical trials for epigenetic drugs. Combining epigenetic drugs with targeted therapies might represent a promising approach for treating pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Shunhao Zhang, Sining Duan, Zhuojun Xie, Wanlin Bao, Bo Xu, Wenbin Yang, Lingyun Zhou
Summary: The NRF2/KEAP1 signaling pathway plays a key role in cellular physiology by protecting cells from stress conditions. However, recent studies have shown that this pathway may have oncogenic effects and contribute to therapy resistance. This article investigates the role of epigenetic modifications in regulating the NRF2/KEAP1 signaling pathway and its impact on cancer development, and explores the potential of targeting epigenetic changes as therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Wang, Xiaolong Du, Mingxing Chu, Xiaoyun He
Summary: This study investigated the effects of photoperiod on the expression and epigenetic changes of the GNAQ gene. The results showed that photoperiod can induce DNA methylation in the core promoter region and histone acetylation in the promoter region of the GNAQ gene. These findings are important for understanding the role of epigenetic modifications in reproduction in sheep.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Pharmacology & Pharmacy
Junying Lu, Yuanyuan Huang, Xiaohao Zhang, Yang Xu, Shu Nie
Summary: Diabetes, a metabolic disorder, leads to vascular complications, accelerated by mechanisms such as oxidative stress and inflammation caused by high blood glucose. Epigenetic modifications and non-coding RNAs play important roles in the pathogenesis of diabetic vascular complications.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Caglar Berkel, Ercan Cacan
Summary: This study identified differential expression of miRNAs in serous OC based on tumor stage and grade. Some of the top miRNAs were associated with patient survival, and most of them have not been previously studied in the context of OC. Mechanistic studies of these miRNAs may be vital in developing novel treatment strategies for serous ovarian cancer.
Article
Geriatrics & Gerontology
Caglar Berkel, Ercan Cacan
Summary: The study examines the variation in longevity among animals, particularly in Chordata, identifying species with exceptional longevity within different taxonomic ranks. It suggests that ecological variables and mode-of-life traits may contribute to longer lifespans in certain species. Despite the positive skewness towards increased longevity in most taxa, potential biases in data collection should be considered.
Article
Cell Biology
Caglar Berkel, Ercan Cacan
Summary: The study found that human cancer cell lines isolated from metastatic sites have a higher potential to metastasize to another site in mice compared to those from primary sites, but this potential seems to be cancer type-dependent. In certain types of cancer, cell lines from primary tumors have increased metastatic potential.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Caglar Berkel, Ercan Cacan
Summary: CEP89 is overexpressed in ovarian cancer and associated with shorter overall survival. It may serve as a prognostic marker and therapeutic target.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Letter
Cell Biology
Caglar Berkel, Ercan Cacan
Article
Immunology
Burak Kucuk, Ercan Cacan
Summary: This study analyzed genomic and gene expression data to investigate the regulation of NKG2DLs in lung adenocarcinoma (LUAD). The results showed that NKG2DLs, particularly MICA, were downregulated in LUAD compared to normal samples. Downregulated MICA transcript expression may be a prognostic indicator for LUAD. However, the mechanisms underlying the downregulation of MICA were not clarified in this study.
Article
Pathology
Feyzanur Yildirimtepe Caldiran, Ercan Cacan
Summary: Colorectal cancer is the third most common cancer, with genetic and epigenetic changes playing major roles in its development. The expression of RGS10 is regulated by DNA methylation, and its role in colorectal carcinoma varies depending on tumor stage and microsatellite stability.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Caglar Berkel, Ercan Cacan
Summary: Gasdermin proteins form pores in cell membranes upon stimuli, leading to pyroptotic cell death. NINJ1 has been identified as responsible for plasma membrane rupture following lytic cell death mechanisms. The study found differential expression of GSDMD and GSDME proteins in ovarian tumors, with low NINJ1 expression associated with poorer prognosis.
IMMUNOLOGIC RESEARCH
(2023)
Article
Psychology, Biological
Caglar Berkel, Ercan Cacan
Summary: Predation is a psychological stressor for prey animals, influencing their behavior, dynamics, and physiology. Using gene expression data from wild yellow-bellied marmots, it was found that female marmots had a higher number of differentially expressed genes in response to predator stress compared to males. Only a small percentage of these genes were shared between the sexes, with most of the differentially expressed genes being expressed in a sex-specific manner.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Caglar Berkel, Ercan Cacan
Summary: Certain dietary supplements and caloric-restricted diets can promote weight loss by increasing CNDP2 expression in adipose tissue, leading to the synthesis of Lac-Phe that suppresses feeding and obesity. The effect of t10-c12 conjugated linoleic acid on CNDP2 expression may be isomer-specific. Understanding the regulation of CNDP2 expression in diverse tissues is important for the treatment of obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Caglar Berkel, Ercan Cacan
Summary: Pyroptosis is a form of lytic cell death characterized by inflammation, which is induced by specific inflammatory caspases and inflammasome complexes such as NLRP3 inflammasome. Gasdermins play a role in pyroptosis by forming cell membrane pores and releasing inflammatory cytokines, causing damage to the cell membrane. Recent studies have shown that various pollutants can induce pyroptotic cell death in different tissues. This review focuses on the current understanding of pollutant-induced pyroptosis and the upstream events leading to pyroptotic cell death upon exposure to pollutants.
Review
Parasitology
Caglar Berkel, Ercan Cacan
Summary: Immunological capability shows sexual dimorphism in animals, with females generally being more immunocompetent than males. This study investigated the sex differences in parasitemia of three different parasite lineages in a bird community, and found that male birds had higher parasitemia than females for one of the lineages. The study suggests that sexual dimorphism in parasitemia might be more common in birds than previously thought, potentially impacting population dynamics in a sex-specific manner.
PARASITOLOGY RESEARCH
(2023)
Letter
Obstetrics & Gynecology
Caglar Berkel, Ercan Cacan
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Caglar Berkel, Ercan Cacan
Summary: GALNT7 expression is associated with the positive status of estrogen receptor, progesterone receptor, and HER2 in breast cancer. High GALNT7 expression is related to favorable prognosis and survival rate in breast cancer patients.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Genetics & Heredity
Feyzanur Yildirimtepe Caldiran, Caglar Berkel, Koksal Deveci, Ercan Cacan
Summary: The expression and methylation status of NLRP13 gene vary in different cancer types, and are associated with cancer progression and patient prognosis.
