Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study

(2017) Martin J van den Bent et al.   LANCET

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

(2017) Tyler E. Miller et al.   NATURE

Lomustine and Bevacizumab in Progressive Glioblastoma

(2017) Wolfgang Wick et al.   NEW ENGLAND JOURNAL OF MEDICINE

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL

(2017) Ibrahim Cagri Kurt et al.   Cell Death & Disease

Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin

(2016) HIKARU WATARAI et al.   ANTICANCER RESEARCH

Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis

(2016) Jaclyn Andricovich et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer stem cells

(2016) Jeremy N. Rich   MEDICINE

An epigenetic gateway to brain tumor cell identity

(2016) Stephen C Mack et al.   NATURE NEUROSCIENCE

Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance

(2016) S Ramadoss et al.   ONCOGENE

Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine

(2016) Mikkel Staberg et al.   CELLULAR ONCOLOGY

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2

(2015) T. Ueda et al.   BLOOD

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma

(2015) Barbara Banelli et al.   CELL CYCLE

Advances in the development of histone lysine demethylase inhibitors

(2015) Tamara Maes et al.   CURRENT OPINION IN PHARMACOLOGY

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

(2015) Yuhui Jiang et al.   NATURE CELL BIOLOGY

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

(2015) Stefano Amente et al.   Oncotarget

Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21

(2014) Bin Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells

(2014) F. Kottakis et al.   CANCER RESEARCH

The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis

(2014) Takeshi Inagaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial

(2014) Walter Taal et al.   LANCET ONCOLOGY

Inhibition of demethylases by GSK-J1/J4

(2014) Bo Heinemann et al.   NATURE

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

(2014) Ekapun Karoopongse et al.   PLoS One

The histone LSD1 demethylase in stemness and cancer transcription programs

(2013) Stefano Amente et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

(2013) Joshua C. Black et al.   CELL

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(2013) Jin He et al.   NATURE CELL BIOLOGY

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

Is Glioblastoma an Epigenetic Malignancy?

(2013) Marta Maleszewska et al.   Cancers

Epigenetics in human gliomas

(2012) Simone Kreth et al.   CANCER LETTERS

Histone Demethylase KDM5B Collaborates with TFAP2C and Myc To Repress the Cell Cycle Inhibitor p21cip (CDKN1A)

(2012) P.-P. Wong et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

The role of histone demethylases in cancer therapy

(2012) Inga Hoffmann et al.   Molecular Oncology

Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming

(2012) Gaoyang Liang et al.   NATURE CELL BIOLOGY

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

(2011) J. He et al.   BLOOD

Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells

(2011) Alexandros Tzatsos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

(2011) V. Ginjala et al.   MOLECULAR AND CELLULAR BIOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

Histone demethylases in development and disease

(2010) Marianne Terndrup Pedersen et al.   TRENDS IN CELL BIOLOGY

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing theInk4a/Arflocus

(2009) Alexandros Tzatsos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

(2008) Jin He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY