Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

Integrated Testing Strategy (ITS) – Opportunities to better use existing data and guide future testing in toxicology

(2016) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

(2015) Thomas Luechtefeld et al.   JOURNAL OF APPLIED TOXICOLOGY

In silico risk assessment for skin sensitization using artificial neural network analysis

(2015) Kyoko Tsujita-Inoue et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Assessing skin sensitization hazard in mice and men using non-animal test methods

(2015) Daniel Urbisch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

(2015) Vinicius M. Alves et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

(2015) Kerstin Reisinger et al.   TOXICOLOGY IN VITRO

LLNA variability: An essential ingredient for a comprehensive assessment of non-animal skin sensitization test methods and strategies

(2015) Sebastian Hoffmann   ALTEX-Alternatives to Animal Experimentation

Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

(2014) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

TIMES-SS – Recent refinements resulting from an industrial skin sensitisation consortium

(2014) G. Patlewicz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

(2014) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway Development II: Best Practices

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

(2014) Kyoko Tsujita-Inoue et al.   TOXICOLOGY IN VITRO

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

(2014) David Basketter   ALTEX-Alternatives to Animal Experimentation

Integrated testing strategies for safety assessments

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients

(2013) Osamu Takenouchi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Allergic Skin Inflammation Induced by Chemical Sensitizers Is Controlled by the Transcription Factor Nrf2

(2013) Zeina El Ali et al.   TOXICOLOGICAL SCIENCES

Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

(2012) Yuri Dancik et al.   ADVANCED DRUG DELIVERY REVIEWS

Induction of skin sensitization is augmented in Nrf2-deficient mice

(2012) Jochem W. van der Veen et al.   ARCHIVES OF TOXICOLOGY

Non-animal test methods for predicting skin sensitization potentials

(2012) Annette Mehling et al.   ARCHIVES OF TOXICOLOGY

Quantifying Processes Determining the Free Concentration of Phenanthrene in Basal Cytotoxicity Assays

(2012) Nynke I. Kramer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation

(2012) Philipp R. Esser et al.   PLoS One

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation

(2012) Bart De Wever et al.   TOXICOLOGY IN VITRO

Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Relating Skin Sensitizing Potency to Chemical Reactivity: Reactive Michael Acceptors Inhibit NF-κB Signaling and Are Less Sensitizing than SNAr- and SN2- Reactive Chemicals

(2011) Andreas Natsch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach

(2011) Nicholas Ball et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells

(2010) James M. McKim et al.   Cutaneous and Ocular Toxicology

Lack of the purinergic receptor P2X7results in resistance to contact hypersensitivity

(2010) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Towards optimization of chemical testing under REACH: A Bayesian network approach to Integrated Testing Strategies

(2010) Joanna Jaworska et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Chemical Allergy: Translating Biology into Hazard Characterization

(2010) I. Kimber et al.   TOXICOLOGICAL SCIENCES

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic ElectrophilesApplication to α,β-Unsaturated Ketones, Acrylates, and Propiolates

(2009) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Updating the skin sensitizationin vitrodata assessment paradigm in 2009

(2009) David A. Basketter et al.   JOURNAL OF APPLIED TOXICOLOGY

Oxidation of Cell Surface Thiol Groups by Contact Sensitizers Triggers the Maturation of Dendritic Cells

(2009) Saori Kagatani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Toxicity Testing in the 21st Century: A View from the Chemical Industry

(2009) James S. Bus et al.   TOXICOLOGICAL SCIENCES

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

(2009) Andreas Natsch   TOXICOLOGICAL SCIENCES

Mathematical Modelling of Immune Response in Tissues

(2008) B. Su et al.   Computational and Mathematical Methods in Medicine

Role of MAPK signaling pathway in the activation of dendritic type cell line, THP-1, induced by DNCB and NiSO4

(2008) Masaaki Miyazawa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Determinants of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients

(2007) Anne Marie Api et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY