Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

Systems Biology Approach Reveals a Calcium-Dependent Mechanism for Basal Toxicity in Daphnia magna

(2015) Philipp Antczak et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicity testing in the 21st century beyond environmental chemicals

(2015) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

From “weight of evidence” to quantitative data integration using multicriteria decision analysis and Bayesian methods

(2015) Igor Linkov   ALTEX-Alternatives to Animal Experimentation

Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

(2014) Jochem W. van der Veen et al.   CRITICAL REVIEWS IN TOXICOLOGY

Are Adverse Outcome Pathways Here to Stay?

(2014) Natàlia Garcia-Reyero   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A novel framework for interpretation of data from the fish short-term reproduction assay (FSTRA) for the detection of endocrine-disrupting chemicals

(2014) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

(2014) Nicole C Kleinstreuer et al.   NATURE BIOTECHNOLOGY

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Mode of action analysis for liver tumors from oral 1,4-dioxane exposures and evidence-based dose response assessment

(2014) Michael Dourson et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Development of a chronic fish toxicity model for predicting sub-lethal NOEC values for non-polar narcotics

(2014) T.J. Austin et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway Development II: Best Practices

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Pathways of Toxicity

(2014) Andre Kleensang et al.   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

Pathway-based toxicity: history, current approaches and liver fibrosis and steatosis as prototypes

(2014) Catherine Willett   ALTEX-Alternatives to Animal Experimentation

Development and validation of a quantitative structure-activity relationship for chronic narcosis to fish

(2013) Lieve Claeys et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Investigating Alternatives to the fish early-life stage test: A strategy for discovering and annotating adverse outcome pathways for early fish development

(2013) Daniel Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling

(2013) Miyuki Breen et al.   TOXICOLOGICAL SCIENCES

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

Advancing the Next Generation of Health Risk Assessment

(2012) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Coagulation and cancer: biological and clinical aspects

(2012) A. FALANGA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Emerging Signaling Pathways in Hepatocellular Carcinoma

(2012) Agrin Moeini et al.   Liver Cancer

Chemistry-Based Risk Assessment for Skin Sensitization: Quantitative Mechanistic Modeling for the SNAr Domain

(2011) D. W. Roberts et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of aquatic experimental versus predicted and extrapolated chronic toxicity data of four structural analogues

(2011) Nathalie Dom et al.   CHEMOSPHERE

Physiological and Molecular Effect Assessment versus Physico-Chemistry Based Mode of Action Schemes: Daphnia magna Exposed to Narcotics and Polar Narcotics

(2011) Nathalie Dom et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

Adverse Outcome Pathways during Early Fish Development: A Conceptual Framework for Identification of Chemical Screening and Prioritization Strategies

(2011) David C. Volz et al.   TOXICOLOGICAL SCIENCES

TimeDelay-ARACNE: Reverse engineering of gene networks from time-course data by an information theoretic approach

(2010) Pietro Zoppoli et al.   BMC BIOINFORMATICS

Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

(2010) Jason E Shoemaker et al.   BMC Systems Biology

The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

(2010) Markus Hecker et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects

(2010) Vincent J. Kramer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Carcinogenicity studies of 1,4-dioxane administered in drinking-water to rats and mice for 2years

(2009) Hirokazu Kano et al.   FOOD AND CHEMICAL TOXICOLOGY

Two-year inhalation study of carcinogenicity and chronic toxicity of 1,4-dioxane in male rats

(2009) Tatsuya Kasai et al.   INHALATION TOXICOLOGY

Role of Tissue Factor in Cancer

(2009) Raj S. Kasthuri et al.   JOURNAL OF CLINICAL ONCOLOGY

The physicochemical basis of QSARs for baseline toxicity

(2009) D. Mackay et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

An overview of coagulation disorders in cancer patients

(2009) Slavica Kvolik et al.   SURGICAL ONCOLOGY-OXFORD

Effects on coagulation factor production following primaryhepatomitogen-induced direct hyperplasia

(2009) Kohei Tatsumi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ecotoxicology of narcosis: Stereoselectivity and potential target sites

(2008) Heinrich Sandermann   CHEMOSPHERE

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation

(2007) Stephen M. Black et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients

(2007) Anne Marie Api et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY