Limitations of toxicity characterization in life cycle assessment: Can adverse outcome pathways provide a new foundation?

Data-Driven Method to Estimate Nonlinear Chemical Equivalence

(2015) Michael Mayo et al.   PLoS One

Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality

(2014) Christine L. Russom et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Uncertainty in multi-media fate and transport models: A case study for TNT life cycle assessment

(2014) Michael Mayo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Validation of a Genomics-Based Hypothetical Adverse Outcome Pathway: 2,4-Dinitrotoluene Perturbs PPAR Signaling Thus Impairing Energy Metabolism and Exercise Endurance

(2014) Mitchell S. Wilbanks et al.   TOXICOLOGICAL SCIENCES

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Quantifying the Trade-off between Parameter and Model Structure Uncertainty in Life Cycle Impact Assessment

(2013) Rosalie van Zelm et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling

(2013) Miyuki Breen et al.   TOXICOLOGICAL SCIENCES

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: I. Data Generation in a Small Fish Model

(2013) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

(2013) Katie B. Paul et al.   TOXICOLOGY IN VITRO

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone

(2011) Zhenhong Li et al.   BMC Systems Biology

Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics

(2011) Natàlia Garcia-Reyero et al.   ECOTOXICOLOGY

Coupling Multi-Criteria Decision Analysis, Life-Cycle Assessment, and Risk Assessment for Emerging Threats

(2011) Igor Linkov et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties

(2011) Ralph K. Rosenbaum et al.   INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT

Use of Multicriteria Decision Analysis to Support Weight of Evidence Evaluation

(2011) Igor Linkov et al.   RISK ANALYSIS

Why and how to combine evidence in environmental assessments: Weighing evidence and building cases

(2011) Glenn W. Suter et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

(2010) Jason E Shoemaker et al.   BMC Systems Biology

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

(2010) Karen H. Watanabe et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Systems biology: Leading the revolution in ecotoxicology

(2010) Natàlia Garcia-Reyero et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Reverse engineering adverse outcome pathways

(2010) Edward J. Perkins et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects

(2010) Vincent J. Kramer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Assessing regional intake fractions in North America

(2009) Sebastien Humbert et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Weight-of-evidence evaluation in environmental assessment: Review of qualitative and quantitative approaches

(2009) Igor Linkov et al.   SCIENCE OF THE TOTAL ENVIRONMENT

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

A General Approach to Modeling Biphasic Relationships

(2008) William N. Beckon et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

USEtox—the UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in life cycle impact assessment

(2008) Ralph K. Rosenbaum et al.   INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT

A weight of evidence approach to causal inference

(2008) Gerard Swaen et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Coupling Multicriteria Decision Analysis and Life Cycle Assessment for Nanomaterials

(2008) Thomas P. Seager et al.   JOURNAL OF INDUSTRIAL ECOLOGY

Characterizing, Propagating, and Analyzing Uncertainty in Life-Cycle Assessment: A Survey of Quantitative Approaches

(2007) Shannon M. Lloyd et al.   JOURNAL OF INDUSTRIAL ECOLOGY