Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence

Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations.

(2019) Dustin Flanagan et al.   CANCER RESEARCH

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies

(2019) Swetha Raman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Frizzled-Related Protein 2 Is Associated with Disease Progression and Poor Prognosis in Breast Cancer

(2019) Chumei Huang et al.   DISEASE MARKERS

The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation

(2019) Sanne M. van Neerven et al.   DIFFERENTIATION

The Wnt signaling pathway: a potential therapeutic target against cancer

(2019) Noyel Ghosh et al.   Annals of the New York Academy of Sciences

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression

(2019) S. J. Kim et al.   ONCOGENE

TP53 Mutations Promote Immunogenic Activity in Breast Cancer

(2019) Zhixian Liu et al.   Journal of Oncology

Wnt signaling in cancer: not a binary ON:OFF switch

(2019) Dustin J Flanagan et al.   CANCER RESEARCH

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

(2019) Rachel Eyre et al.   Nature Communications

A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors

(2019) Ólöf Gerdur Ísberg et al.   Scientific Reports

LGR5 overexpression confers poor relapse-free survival in breast cancer patients

(2018) Ming-Feng Hou et al.   BMC CANCER

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Aberrant Expression of miR-142-3p and its Target Gene HMGA1 and FZD7 in Breast Cancer and its Clinical Significance

(2018) Xiu-Peng Jia et al.   Clinical Laboratory

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Early lineage segregation of multipotent embryonic mammary gland progenitors

(2018) Aline Wuidart et al.   NATURE CELL BIOLOGY

Dramatic dysbalancing of the Wnt pathway in breast cancers

(2018) Alexey Koval et al.   Scientific Reports

Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1

(2018) Jingying Cao et al.   Theranostics

Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling

(2018) Justin A. Colacino et al.   Stem Cell Reports

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

(2018) Yuemin Celina Chee et al.   DEVELOPMENTAL CELL

Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy

(2018) Kacey VanderVorst et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

71OPhase I extension study of ETC-159 an oral PORCN inhibitor administered with bone protective treatment, in patients with advanced solid tumours

(2018) D Tan et al.   ANNALS OF ONCOLOGY

TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

(2018) Nikolaos Doumpas et al.   EMBO JOURNAL

Wnt7a Deficiency Could Predict Worse Disease-Free and Overall Survival in Estrogen Receptor-Positive Breast Cancer

(2017) Kijong Yi et al.   Journal of Breast Cancer

Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion

(2017) Jinlu Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells

(2017) Biancastella Cereser et al.   JOURNAL OF PATHOLOGY

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Identity and dynamics of mammary stem cells during branching morphogenesis

(2017) Colinda L. G. J. Scheele et al.   NATURE

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1

(2017) Xueqian Zhuang et al.   NATURE CELL BIOLOGY

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions

(2017) Marc Damelin et al.   Science Translational Medicine

Frizzled7 Antibody-Functionalized Nanoshells Enable Multivalent Binding for Wnt Signaling Inhibition in Triple Negative Breast Cancer Cells

(2017) Rachel S. Riley et al.   Small

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

(2017) Marcus M. Fischer et al.   Science Advances

Animal multicellularity and polarity without Wnt signaling

(2017) Quentin Schenkelaars et al.   Scientific Reports

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues

(2016) Ashwini Balakrishnan et al.   CLINICAL CANCER RESEARCH

Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules

(2016) Yukio Nakamura et al.   DEVELOPMENT

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

(2016) Kyle M. Loh et al.   DEVELOPMENTAL CELL

Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells

(2016) Aline Wuidart et al.   GENES & DEVELOPMENT

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

(2016) Leander Blaas et al.   NATURE CELL BIOLOGY

Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling

(2016) Annika Jacobsen et al.   PLoS One

Expression of ROR1 has prognostic significance in triple negative breast cancer

(2016) Hui-Ping Chien et al.   VIRCHOWS ARCHIV

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

(2016) Alexandra Avgustinova et al.   Nature Communications

Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny

(2016) Felicity M. Davis et al.   Nature Communications

Decreased Wnt5a Expression is a Poor Prognostic Factor in Triple-Negative Breast Cancer

(2016) ZhenBin Zhong et al.   MEDICAL SCIENCE MONITOR

Murine mammary stem/progenitor cell isolation: Different method matters?

(2016) Hui Gao et al.   SpringerPlus

Mammary Development and Breast Cancer: A Wnt Perspective

(2016) Qing Yu et al.   Cancers

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells

(2015) N. Borcherding et al.   CANCER RESEARCH

Quantification of regenerative potential in primary human mammary epithelial cells

(2015) J. R. Linnemann et al.   DEVELOPMENT

Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy

(2015) Mahdi Shabani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium

(2015) Kevin Roarty et al.   JOURNAL OF CELL BIOLOGY

Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation

(2015) Gabriela Dontu et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Molecular characteristics of recurrent triple-negative breast cancer

(2015) CHUNG-HSIN TSAI et al.   Molecular Medicine Reports

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity

(2015) Alexandra Van Keymeulen et al.   NATURE

PIK3CAH1047R induces multipotency and multi-lineage mammary tumours

(2015) Shany Koren et al.   NATURE

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

Comprehensive DNA Methylation and Extensive Mutation Analyses of HER2-Positive Breast Cancer

(2015) Takeshi Yamaguchi et al.   ONCOLOGY

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway

(2015) Qian Jiang et al.   TUMOR BIOLOGY

Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway

(2015) Tsai-Hsien Hung et al.   Oncotarget

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Benign Breast Tissue Composition in Breast Cancer Patients: Association with Risk Factors, Clinical Variables, and Gene Expression

(2014) X. Sun et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer

(2014) E.-J. Yeo et al.   CANCER RESEARCH

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Whole genome DNA methylation signature of HER2-positive breast cancer

(2014) Breezy M Lindqvist et al.   Epigenetics

Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling

(2014) C. Henry et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Taxonomy of breast cancer based on normal cell phenotype predicts outcome

(2014) Sandro Santagata et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of multipotent mammary stem cells by protein C receptor expression

(2014) Daisong Wang et al.   NATURE

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

(2014) Rumela Chakrabarti et al.   NATURE CELL BIOLOGY

PTK 7 Is a Transforming Gene and Prognostic Marker for Breast Cancer and Nodal Metastasis Involvement

(2014) Silvia Gärtner et al.   PLoS One

Both Canonical and Non-Canonical Wnt Signaling Independently Promote Stem Cell Growth in Mammospheres

(2014) Alexander M. Many et al.   PLoS One

Human Breast Progenitor Cell Numbers Are Regulated by WNT and TBX3

(2014) Lisa M. Arendt et al.   PLoS One

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Validation of DNA promoter hypermethylation biomarkers in breast cancer — a short report

(2014) Jolien S. de Groot et al.   CELLULAR ONCOLOGY

Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis

(2013) B. Cui et al.   CANCER RESEARCH

Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

(2013) Lili Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

(2013) Peter Wend et al.   EMBO Molecular Medicine

Expression and significance of Wnt signaling components and their target genes in breast carcinoma

(2013) YANJIAO HE et al.   Molecular Medicine Reports

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells

(2013) Rebecca Lamb et al.   PLoS One

Differential Activation of Wnt-β-Catenin Pathway in Triple Negative Breast Cancer Increases MMP7 in a PTEN Dependent Manner

(2013) Nandini Dey et al.   PLoS One

Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44

(2013) S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

(2013) J. L. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Small GTPase ARF6 Stimulates  -Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

(2013) A. H. Grossmann et al.   Science Signaling

Loss of WIF-1 and Wnt5a expression is related to aggressiveness of sporadic breast cancer in Tunisian patients

(2013) Fatma Trifa et al.   TUMOR BIOLOGY

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland

(2012) Renée van Amerongen et al.   Cell Stem Cell

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

(2012) Renée van Amerongen et al.   DEVELOPMENTAL BIOLOGY

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity

(2012) Frances L. Shaw et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

(2012) Karin E de Visser et al.   JOURNAL OF PATHOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth

(2012) Suping Zhang et al.   PLoS One

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential gene expression of Wnt signaling pathway in benign, premalignant, and malignant human breast epithelial cells

(2012) Yu-Zhou Wang et al.   TUMOR BIOLOGY

Alternative Wnt Pathways and Receptors

(2012) R. van Amerongen   Cold Spring Harbor Perspectives in Biology

Cadherin–catenin complex dissociation in lobular neoplasia of the breast

(2011) Mary Morrogh et al.   BREAST CANCER RESEARCH AND TREATMENT

Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers

(2011) Bryan D. White et al.   GASTROENTEROLOGY

Distinct stem cells contribute to mammary gland development and maintenance

(2011) Alexandra Van Keymeulen et al.   NATURE

FZD7 has a critical role in cell proliferation in triple negative breast cancer

(2011) L Yang et al.   ONCOGENE

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis

(2010) F. Klemm et al.   CARCINOGENESIS

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast

(2010) Magali Lacroix-Triki et al.   MODERN PATHOLOGY

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer

(2009) Jürgen Veeck et al.   BMC CANCER

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

A gene expression signature that defines breast cancer metastases

(2009) Rachel E. Ellsworth et al.   CLINICAL & EXPERIMENTAL METASTASIS

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development

(2009) Charlotta Lindvall et al.   PLoS One

The Wnt Receptor, Lrp5, Is Expressed by Mouse Mammary Stem Cells and Is Required to Maintain the Basal Lineage

(2009) Nisha M. Badders et al.   PLoS One

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

(2009) Claudia Gaspar et al.   PLoS Genetics

Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype

(2008) I Van der Auwera et al.   BRITISH JOURNAL OF CANCER

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

(2008) H Suzuki et al.   BRITISH JOURNAL OF CANCER

Epigenetic inactivation of the secreted frizzled-related protein-5 ( SFRP5 ) gene in human breast cancer is associated with unfavorable prognosis

(2008) Jürgen Veeck et al.   CARCINOGENESIS

Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast

(2008) M. J. Hayes et al.   CLINICAL CANCER RESEARCH

The Wnt-5a-Derived Hexapeptide Foxy-5 Inhibits Breast Cancer Metastasis In vivo by Targeting Cell Motility

(2008) A. Safholm et al.   CLINICAL CANCER RESEARCH

Epigenetic alterations of CDH1 and APC genes: Relationship with activation of Wnt/β-catenin Pathway in invasive ductal carcinoma of breast

(2008) Chandra P. Prasad et al.   LIFE SCIENCES

Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

(2008) Jürgen Veeck et al.   Molecular Cancer