Article
Endocrinology & Metabolism
Vanessa J. De-Paula, Carla Cristine C. dos Santos, Maria Carolina A. Luque, Taccyana M. Ali, Jorge E. Kalil, Orestes V. Forlenza, Edecio Cunha-Neto
Summary: This study evaluated the effect of acute and chronic lithium treatment on the expression of beta-catenin target genes in the brain of mice. The results showed that lithium treatment up-regulated the expression of these genes, with a positive correlation between serum lithium concentrations and gene expression levels.
METABOLIC BRAIN DISEASE
(2021)
Article
Plant Sciences
Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen
Summary: This study found that Portulaca oleracea extract (POE) inhibited the development of colorectal cancer (CRC) by regulating gut microbiota imbalance, inactivating the Wnt/beta-catenin signaling pathway, and downregulating the expression of c-Myc and cyclin D1.
Article
Nutrition & Dietetics
Jun Chen, Zhiguang Duan, Yannan Liu, Rongzhan Fu, Chenhui Zhu
Summary: This study found that ginsenoside Rh4 inhibits the metastasis of esophageal squamous cell carcinoma (ESCC) by regulating the Wnt/beta-catenin signaling pathway and the level of c-Myc. In vitro and in vivo experiments confirmed the inhibitory effect of Rh4 on ESCC metastasis.
Review
Medicine, Research & Experimental
Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, Xin Chen
Summary: Deregulated Wnt/β-catenin signaling is a major genetic alteration in hepatocellular carcinoma (HCC), and its activation plays an oncogenic role in hepatocarcinogenesis. The activated pathway is associated with specific gene expression patterns and pathological features, and it synergizes with other signaling cascades to promote HCC formation. Therefore, understanding and targeting this pathway has important implications for the diagnosis, classification, and personalized treatment of HCC.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-ll Park, Yi Zheng, Kwon-Sik Park
Summary: This study characterizes the activity of the WNT pathway in small cell lung cancer (SCLC) and identifies the key role of the WNT5A-RHOA axis in SCLC progression. It provides potential targets for therapeutic interventions and biomarkers to improve patient treatment.
Article
Oncology
Adnan Shami Shah, Xiaofu Cao, Andrew C. White, Jeremy M. Baskin
Summary: The study identifies PLEKHA4 as a crucial factor for melanoma proliferation and survival, demonstrating its essential role in Wnt/beta-catenin signaling. Knocking down PLEKHA4 attenuated tumor growth in both BRAF- and NRAS-mutant melanoma models, with an additive effect when combined with the clinically used inhibitor encorafenib in the BRAF-mutant model. As an E3 ubiquitin ligase regulator, PLEKHA4 presents promising opportunities for targeting in melanoma therapy.
Article
Medicine, Research & Experimental
Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Summary: The study demonstrates that miR-218 acts as a downstream effector of Notch signaling in quiescent endothelial cells, inhibiting cell proliferation and sprouting, and could be a potential treatment for angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Ana R. Moshkovsky, Marc W. Kirschner
Summary: Axin is a crucial protein in the canonical Wnt pathway, and its differential regulation allows for tissue-specific functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei, Weiguo Hu
Summary: This study uncovers the activation of C5 complement within tumor cells, which affects colorectal tumorigenesis by regulating the stability of beta-catenin. The findings provide a potential target for tumor prevention and treatment.
Article
Oncology
Himanshu Singh Saroha, Rohith Kumar Guddeti, Jasmine P. Jacob, Kiran Kumar Pulukuri, Prashanthi Karyala, Suresh B. Pakala
Summary: The expression of MORC2 is positively correlated with beta-catenin in breast cancer, and overexpression of MORC2 increases beta-catenin and its target genes. The target gene of beta-catenin, c-Myc, regulates the MORC2-beta-catenin signaling axis through a feedback mechanism. MORC2 regulates beta-catenin expression and function by modulating AKT phosphorylation, promoting proliferation and migration of breast cancer cells.
Article
Cell Biology
Yan Lu, Yijia Shao, Yinping Xie, Huinan Qu, Da Qi, Yuan Dong, Qiu Jin, Liping Wang, Junyuan Wei, Chengshi Quan
Summary: Overexpression of CLAUDIN6 can inhibit the malignant behavior of breast cancer by suppressing cell proliferation, migration, and invasion. CLAUDIN6 achieves this effect by inhibiting the ERK/Sp1/cyclin D1 and ERK/IL-8 signaling pathways.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Bi-juan Yang, Shi-rui Fan, Xin-fang Zhang, Jie-yun Cai, Ting Ruan, Zheng-rui Xiang, Juan Ren, Xiao-jiang Hao, Duo-zhi Chen
Summary: This study explores the potential of activating the Wnt/β-catenin signaling pathway for the treatment of vitiligo through the design and synthesis of compounds. The results suggest that compounds 41 and 43 may be potential candidates for vitiligo treatment.
BIOORGANIC CHEMISTRY
(2022)
Article
Oncology
Lijuan Yin, Qinlong Li, Stefan Mrdenovic, Gina Chia-Yi Chu, Boyang Jason Wu, Hong Bu, Peng Duan, Jayoung Kim, Sungyong You, Michael S. Lewis, Gangning Liang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung
Summary: This study reveals that KRT13 promotes breast cancer growth and metastasis via the plakoglobin/c-Myc pathway. Overexpression of KRT13 in breast cancer cells leads to increased aggressive behaviors, while knockdown of KRT13 inhibits these behaviors. High expression of KRT13 in breast cancer tissues is associated with decreased patient survival.
BREAST CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays. RapMIF is a rapid multiplexed immunofluorescence method that can measure the spatial protein maps of up to 25 proteins, providing combinatorial signaling states and enabling precision therapy design.
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)