Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing

Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway

(2019) Arisa Takeuchi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNA profiling and identification of let-7a as a target to prevent chemotherapy-induced primordial follicles apoptosis in mouse ovaries

(2019) C. Alexandri et al.   Scientific Reports

PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage

(2019) Daniela Madanes et al.   GYNECOLOGICAL ENDOCRINOLOGY

Ovarian damage from chemotherapy and current approaches to its protection

(2019) N Spears et al.   HUMAN REPRODUCTION UPDATE

Answer to Controversy: miR-10a Replacement Approaches Do Not Offer Protection against Chemotherapy-Induced Gonadotoxicity in Mouse Model

(2019) Chrysanthi Alexandri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation

(2019) Yingzheng Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging

(2019) Volkan Turan et al.   HUMAN REPRODUCTION UPDATE

Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis

(2018) Fabio Barra et al.   BRITISH JOURNAL OF PHARMACOLOGY

The capacity of oocytes for DNA repair

(2018) Jessica M. Stringer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dynamics of PI3K and Hippo signaling pathways during in vitro human follicle activation

(2018) J Grosbois et al.   HUMAN REPRODUCTION

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing

(2018) Amy L Winship et al.   HUMAN REPRODUCTION UPDATE

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

(2018) Quynh-Nhu Nguyen et al.   Cell Death & Disease

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes

(2018) Jacinta H. Martin et al.   Scientific Reports

Essential Role of BRCA2 in Ovarian Development and Function

(2018) Ariella Weinberg-Shukron et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRCA carriers have similar reproductive potential at baseline to noncarriers: comparisons in cancer and cancer-free cohorts undergoing fertility preservation

(2018) Vinay Gunnala et al.   FERTILITY AND STERILITY

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response

(2018) Mila Maidarti et al.   HUMAN REPRODUCTION

BRCA1/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro

(2018) Michaël Grynberg et al.   HUMAN REPRODUCTION

Cytotoxicity and DNA Damage Caused from Diazinon Exposure by Inhibiting the PI3K-AKT Pathway in Porcine Ovarian Granulosa Cells

(2018) Wei Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crosstalk between Phosphoinositide 3-kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer

(2018) Ansar Karimian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients With Endometriosis

(2018) Young Sik Choi et al.   Frontiers in Endocrinology

Antimüllerian hormone levels are lower in BRCA2 mutation carriers

(2017) Lauren Johnson et al.   FERTILITY AND STERILITY

Everolimus as an mTOR Inhibitor Suppresses Endometriotic Implants: an Experimental Rat Study

(2017) T. Kacan et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

BRCA1 mutation carriers have a lower number of mature oocytes after ovarian stimulation for IVF/PGD

(2017) I. A. P. Derks-Smeets et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation

(2017) Zohar Gavish et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Control mechanisms in germ cells mediated by p53 family proteins

(2017) Jakob Gebel et al.   JOURNAL OF CELL SCIENCE

Ovarian Aging in Women With BRCA Germline Mutations

(2017) Wayne Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cell Cycle Control by PTEN

(2017) Andrew Brandmaier et al.   JOURNAL OF MOLECULAR BIOLOGY

Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27 Kip1 promoter in primordial follicles

(2017) Hoon Jang et al.   JOURNAL OF PINEAL RESEARCH

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

(2017) Kara N. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

(2017) Linyan Zhou et al.   Journal of Ovarian Research

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries

(2016) Vijayakumar Govindaraj et al.   ANIMAL BIOTECHNOLOGY

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

(2016) J. Dupont et al.   BIOCHEMICAL JOURNAL

Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors

(2016) So-Youn Kim et al.   CANCER RESEARCH

Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced?

(2016) Theodora C. van Tilborg et al.   HUMAN REPRODUCTION

Anti-Müllerian hormone serum concentrations of women with germlineBRCA1orBRCA2mutations

(2016) Kelly-Anne Phillips et al.   HUMAN REPRODUCTION

Bisphenol A-Induced Ovotoxicity Involves DNA Damage Induction to Which the Ovary Mounts a Protective Response Indicated by Increased Expression of Proteins Involved in DNA Repair and Xenobiotic Biotransformation

(2016) Shanthi Ganesan et al.   TOXICOLOGICAL SCIENCES

The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion

(2016) Shanthi Ganesan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

(2016) Daniel Coutandin et al.   eLife

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

(2016) Reza Soleimani et al.   Aging-US

Long-Term Moderate Oxidative Stress Decreased Ovarian Reproductive Function by Reducing Follicle Quality and Progesterone Production

(2016) Liangyan Shi et al.   PLoS One

BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging1

(2015) Kutluk Oktay et al.   BIOLOGY OF REPRODUCTION

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

Functions of the MRE11 complex in the development and maintenance of oocytes

(2015) Akiko Inagaki et al.   CHROMOSOMA

Cell Autonomous Phosphoinositide 3-Kinase Activation in Oocytes Disrupts Normal Ovarian Function Through Promoting Survival and Overgrowth of Ovarian Follicles

(2015) So-Youn Kim et al.   ENDOCRINOLOGY

Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency

(2015) Nao Suzuki et al.   HUMAN REPRODUCTION

Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey

(2015) Dongdong Zhang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Error-Prone Repair of DNA Double-Strand Breaks

(2015) Kasey Rodgers et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair

(2015) Pengda Liu et al.   MOLECULAR CELL

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

(2015) Felix R Day et al.   NATURE GENETICS

Changes in the expression of DNA double strand break repair genes in primordial follicles from immature and aged rats

(2015) Vijayakumar Govindaraj et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats

(2015) Vijayakumar Govindaraj et al.   Systems Biology in Reproductive Medicine

Short-Term PTEN Inhibition Improves In Vitro Activation of Primordial Follicles, Preserves Follicular Viability, and Restores AMH Levels in Cryopreserved Ovarian Tissue From Cancer Patients

(2015) Edurne Novella-Maestre et al.   PLoS One

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

(2015) Eun Mi Chang et al.   PLoS One

BRCA1 germline mutations may be associated with reduced ovarian reserve

(2014) Erica T. Wang et al.   FERTILITY AND STERILITY

Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas

(2014) Michio Kitajima et al.   FERTILITY AND STERILITY

Age-Related Decline in DNA Repair Function Explains Diminished Ovarian Reserve, Earlier Menopause, and Possible Oocyte Vulnerability to Chemotherapy in Women WithBRCAMutations

(2014) Kutluk Oktay et al.   JOURNAL OF CLINICAL ONCOLOGY

Defying DNA Double-Strand Break-Induced Death during Prophase I Meiosis by Temporal TAp63  Phosphorylation Regulation in Developing Mouse Oocytes

(2014) D.-A. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

(2014) M. McLaughlin et al.   MOLECULAR HUMAN REPRODUCTION

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1

(2013) Ying Wang et al.   Autophagy

Ovarian follicle burnout: A universal phenomenon?

(2013) Hadassa Roness et al.   CELL CYCLE

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation

(2013) Amy Finch et al.   FERTILITY AND STERILITY

Ovarian follicle culture: advances and challenges for human and nonhuman primates

(2013) Evelyn E. Telfer et al.   FERTILITY AND STERILITY

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression

(2013) Xing-mei Zhang et al.   GENE

Mutations in the PTEN tumor gene and risk of endometriosis: a case–control study

(2013) Suresh Govatati et al.   HUMAN REPRODUCTION

Redox regulation of tumor suppressor PTEN in cancer and aging

(2013) YASUKO KITAGISHI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles

(2013) Galit Lerer-Serfaty et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The DNA damage response during mitosis

(2013) Anne Margriet Heijink et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling

(2013) Deepak Adhikari et al.   PLoS One

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

(2013) K. Kawamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Cyclophosphamide Triggers Follicle Activation and "Burnout"; AS101 Prevents Follicle Loss and Preserves Fertility

(2013) L. Kalich-Philosoph et al.   Science Translational Medicine

Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

(2013) Emanuele Pelosi et al.   Nature Communications

p63 the guardian of human reproduction

(2012) Ivano Amelio et al.   CELL CYCLE

MicroRNAs and DNA damage response

(2012) Yemin Wang et al.   CELL CYCLE

Oocytes Progress beyond Prophase in the Presence of DNA Damage

(2012) Petros Marangos et al.   CURRENT BIOLOGY

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

(2012) Deepak Adhikari et al.   PLoS One

Current understanding of ovarian aging

(2012) Qian Li et al.   Science China-Life Sciences

RAD51 Plays a Crucial Role in Halting Cell Death Program Induced by Ionizing Radiation in Bovine Oocytes1

(2011) Loro L. Kujjo et al.   BIOLOGY OF REPRODUCTION

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

Quality control in oocytes: Domain-domain interactions regulate the activity of p63

(2011) Gregor B. Deutsch et al.   CELL CYCLE

TAp73 is downregulated in oocytes from women of advanced reproductive age

(2011) Maria Rosa Guglielmino et al.   CELL CYCLE

Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?

(2011) C. R. Hunt et al.   CLINICAL CANCER RESEARCH

PI3K-Akt-mTOR and MAPK signaling pathways in polycystic ovarian syndrome, uterine leiomyomas and endometriosis: an update

(2011) Annu Makker et al.   GYNECOLOGICAL ENDOCRINOLOGY

Increased Activation of the PI3K/AKT Pathway Compromises Decidualization of Stromal Cells from Endometriosis

(2011) Xunqin Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

mTOR signaling in the control of activation of primordial follicles

(2010) Deepak Adhikari et al.   CELL CYCLE

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence

(2010) Omid Tavana et al.   CELL CYCLE

MDC1: The art of keeping things in focus

(2010) Stephanie Jungmichel et al.   CHROMOSOMA

Assembly and function of DNA double-strand break repair foci in mammalian cells

(2010) Simon Bekker-Jensen et al.   DNA REPAIR

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

(2010) Naihan Xu et al.   JOURNAL OF CELL BIOLOGY

Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

(2010) Loro L. Kujjo et al.   PLoS One

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage and repair in human oocytes and embryos: a review

(2010) Yves Ménézo et al.   ZYGOTE

The C-terminus of p63 contains multiple regulatory elements with different functions

(2010) W E Straub et al.   Cell Death & Disease

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

(2009) Deepak Adhikari et al.   ENDOCRINE REVIEWS

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles

(2009) Pradeep Reddy et al.   HUMAN MOLECULAR GENETICS

Expression profiling of DNA repair genes in human oocytes and blastocysts using microarrays

(2009) Souraya Jaroudi et al.   HUMAN REPRODUCTION

The current knowledge on radiosensitivity of ovarian follicle development stages

(2009) I. Adriaens et al.   HUMAN REPRODUCTION UPDATE

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks

(2009) Kutluk Oktay et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetically modified mouse models for premature ovarian failure (POF)

(2009) Krishna Jagarlamudi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

17βE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFκB-dependent pathway

(2009) Hui Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair

(2009) Ali Pedram et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation

(2009) Krishna Jagarlamudi et al.   PLoS One

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

(2008) I. Plo et al.   CANCER RESEARCH

Age-associated increase in aneuploidy and changes in gene expression in mouse eggs

(2008) Hua Pan et al.   DEVELOPMENTAL BIOLOGY

A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause

(2008) K. R. Hansen et al.   HUMAN REPRODUCTION

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN: a new guardian of the genome

(2008) Y Yin et al.   ONCOGENE

Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell–cell interactions during folliculogenesis

(2008) Gretchen Dole et al.   REPRODUCTION

Awakening the oocyte: controlling primordial follicle development

(2008) Eileen A McLaughlin et al.   REPRODUCTION

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE