Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy

(2017) Hoon Jang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Control mechanisms in germ cells mediated by p53 family proteins

(2017) Jakob Gebel et al.   JOURNAL OF CELL SCIENCE

A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice

(2017) Monica M. Laronda et al.   Nature Communications

Quantitative three-dimensional evaluation of immunofluorescence staining for large whole mount spheroids with light sheet microscopy

(2017) I. Smyrek et al.   Biomedical Optics Express

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse

(2016) Valerio Rossi et al.   CELL DEATH AND DIFFERENTIATION

Late endocrine effects of childhood cancer

(2016) Susan R. Rose et al.   Nature Reviews Endocrinology

Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients

(2016) Julia Richter et al.   TUMOR BIOLOGY

Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

(2016) Prashanth Gokare et al.   Oncotarget

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

(2016) Daniel Coutandin et al.   eLife

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

(2016) Reza Soleimani et al.   Aging-US

Dexrazoxane Abrogates Acute Doxorubicin Toxicity in Marmoset Ovary1

(2015) Sana M. Salih et al.   BIOLOGY OF REPRODUCTION

Multifaceted programmed cell death in the mammalian fetal ovary

(2015) Francesca G. Klinger et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Anthracyclines induce double-strand DNA breaks at active gene promoters

(2015) Fan Yang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Therapeutic targeting of casein kinase 1δ in breast cancer

(2015) Laura H. Rosenberg et al.   Science Translational Medicine

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Nucleotide Excision Repair-dependent DNA Double-strand Break Formation and ATM Signaling Activation in Mammalian Quiescent Cells

(2014) Mitsuo Wakasugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fertility preservation in women with cancer

(2014) Michel De Vos et al.   LANCET

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Defying DNA Double-Strand Break-Induced Death during Prophase I Meiosis by Temporal TAp63  Phosphorylation Regulation in Developing Mouse Oocytes

(2014) D.-A. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

(2014) Birgit Schittek et al.   Molecular Cancer

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion

(2013)   FERTILITY AND STERILITY

The dynamics of the primordial follicle reserve

(2013) Jeffrey B Kerr et al.   REPRODUCTION

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Reply to: Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Emiliano Maiani et al.   NATURE MEDICINE

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates

(2011) Mary B. Zelinski et al.   FERTILITY AND STERILITY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Anticancer therapy with checkpoint inhibitors: what, where and when?

(2011) Michelle D. Garrett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

c-Abl phosphorylation of ΔNp63α is critical for cell viability

(2010) M Yuan et al.   Cell Death & Disease

The C-terminus of p63 contains multiple regulatory elements with different functions

(2010) W E Straub et al.   Cell Death & Disease

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Preservation of Fertility in Patients with Cancer

(2009) Jacqueline S. Jeruss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Normal ovarian function and assessment of ovarian reserve in the survivor of childhood cancer

(2009) Robert J. Johnston et al.   PEDIATRIC BLOOD & CANCER

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY