Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

(2018) Marcel Tuppi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure

(2017) Vera D. Rinaldi et al.   MOLECULAR CELL

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

(2016) Daniel Coutandin et al.   eLife

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

(2015) Eun Mi Chang et al.   PLoS One

Is unilateral oophorectomy associated with age at menopause? A population study (the HUNT2 Survey)

(2014) E. K. Bjelland et al.   HUMAN REPRODUCTION

Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice

(2014) Hua Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network

(2013) S-Y Kim et al.   CELL DEATH AND DIFFERENTIATION

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Cisplatin and Doxorubicin Induce Distinct Mechanisms of Ovarian Follicle Loss; Imatinib Provides Selective Protection Only against Cisplatin

(2013) Stephanie Morgan et al.   PLoS One

The dynamics of the primordial follicle reserve

(2013) Jeffrey B Kerr et al.   REPRODUCTION

Cyclophosphamide Triggers Follicle Activation and "Burnout"; AS101 Prevents Follicle Loss and Preserves Fertility

(2013) L. Kalich-Philosoph et al.   Science Translational Medicine

Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

(2013) Emanuele Pelosi et al.   Nature Communications

The Effect of Radiation on Semen Quality and Fertility in Men Treated With Brachytherapy for Early Stage Prostate Cancer

(2012) Dilpreet K. Singh et al.   JOURNAL OF UROLOGY

Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women

(2012) Toshiyuki Yasui et al.   MATURITAS

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Jeffrey B Kerr et al.   NATURE MEDICINE

Exposure to anticancer drugs can result in transgenerational genomic instability in mice

(2012) C. D. Glen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion

(2012) J B Kerr et al.   REPRODUCTION

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?

(2011) A Villunger et al.   CELL DEATH AND DIFFERENTIATION

The ovarian reserve in mammals: A functional and evolutionary perspective

(2011) Philippe Monget et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chemotherapy-Induced Late Transgenerational Effects in Mice

(2011) Loro L. Kujjo et al.   PLoS One

Toxicity of Chemotherapy and Radiation on Female Reproduction

(2010) DROR MEIROW et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer

(2009) William C. Spanos et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries

(2009) Hong Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Apoptosis: Stabbed in the BAX

(2008) Douglas R. Green et al.   NATURE

Making eggs: is it now or later?

(2008) Teresa K Woodruff   NATURE MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY