p63 the guardian of human reproduction

Another "Janus paradox" of p53: induction of cell senescence versus quiescence

(2016) Zbigniew Darzynkiewicz   Aging-US

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence

(2016) Frédérick A. Mallette et al.   Aging-US

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

(2016) Yiping Huang et al.   Aging-US

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

(2016) Lavinia Nardinocchi et al.   Aging-US

p53 governs telomere regulation feedback too, via TRF2

(2016) Izumi Horikawa et al.   Aging-US

Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?

(2016) Vjekoslav Dulic   Aging-US

Spontaneous inactivating p53 mutations and the “selfish cell”

(2016) Steven M. Sorscher et al.   Aging-US

Recent progress in targeting cancer

(2016) Zoya N. Demidenko et al.   Aging-US

Imatinib in chronic myeloid leukemia elderly patients

(2016) Gabriele Gugliotta et al.   Aging-US

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad

(2016) Mathew D. McGee et al.   Aging-US

Caloric restriction: is mammalian life extension linked to p53?

(2016) Paola Tucci   Aging-US

Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction

(2015)   Oncotarget

The requirement of p53 for maintaining chromosomal stability during tetraploidization

(2015)   Oncotarget

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

(2015)   Oncotarget

Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosisy as a Target for Cancer Therapy?

(2015)   Oncotarget

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death

(2015) Naveen Muppani et al.   Oncotarget

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53

(2015)   Oncotarget

A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity

(2015) Benjamin Ory et al.   Oncotarget

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

(2015) Esha Madan et al.   Oncotarget

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

(2015) Richard Hill et al.   Oncotarget

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors

(2015) Valeria G. Antico Arciuch et al.   Oncotarget

The RP-Mdm2-p53 Pathway and Tumorigenesis

(2015) Paula L. Miliani de Marval et al.   Oncotarget

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

EDD induces cell cycle arrest by increasing p53 levels

(2012) Veronique A.J. Smits   CELL CYCLE

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration

(2012) Ivano Amelio et al.   JOURNAL OF CELL BIOLOGY

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Reply to: Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Emiliano Maiani et al.   NATURE MEDICINE

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Jeffrey B Kerr et al.   NATURE MEDICINE

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell death pathology: Cross-talk with autophagy and its clinical implications

(2011) Ivano Amelio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death pathology: Perspective for human diseases

(2011) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles

(2011) Stefano Rufini et al.   BIOCHEMICAL PHARMACOLOGY

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

(2011) Yiping Huang et al.   CELL CYCLE

Regulation of ΔNp63α by NFκΒ 

(2011) Tanusree Sen et al.   CELL CYCLE

p53-mediated induction of Noxa and p53AIP1 requires NFκB

(2011) Jim O’Prey et al.   CELL CYCLE

Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon

(2011) Ulrike Beyer et al.   CELL CYCLE

Quality control in oocytes: Domain-domain interactions regulate the activity of p63

(2011) Gregor B. Deutsch et al.   CELL CYCLE

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

(2011) V Graupner et al.   CELL DEATH AND DIFFERENTIATION

Abl interconnects oncogenic Met and p53 core pathways in cancer cells

(2011) A Furlan et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21WAF1/CIP1

(2011) D Sohn et al.   CELL DEATH AND DIFFERENTIATION

The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans

(2011) A J Ross et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

(2011) M K Leonard et al.   CELL DEATH AND DIFFERENTIATION

The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

(2011) A Vilborg et al.   CELL DEATH AND DIFFERENTIATION

Repression of Puma by Scratch2 is required for neuronal survival during embryonic development

(2011) E Rodríguez-Aznar et al.   CELL DEATH AND DIFFERENTIATION

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

(2011) C Spinnler et al.   CELL DEATH AND DIFFERENTIATION

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Intracellular zinc release-activated ERK-dependent GSK-3β–p53 and Noxa–Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury

(2011) C-L Lin et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes

(2011) Ulrike Beyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors

(2011) A V Vaseva et al.   Cell Death & Disease

NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table

(2011) R Gatta et al.   Cell Death & Disease

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression

(2010) Anna Maria Lena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p73 and p63 regulate the expression of fibroblast growth factor receptor 3

(2010) A. Emre Sayan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa

(2010) M T de Bruijn et al.   BRITISH JOURNAL OF CANCER

PUMA-mediated tumor suppression: A tale of two stories

(2010) Verena Labi et al.   CELL CYCLE

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

(2010) Marina Pajic et al.   CELL CYCLE

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence

(2010) Omid Tavana et al.   CELL CYCLE

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo

(2010) M K Lee et al.   CELL DEATH AND DIFFERENTIATION

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

(2010) L Zhang et al.   CELL DEATH AND DIFFERENTIATION

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

(2010) Ö Yalcin-Ozuysal et al.   CELL DEATH AND DIFFERENTIATION

The microRNA and p53 families join forces against cancer

(2010) N A Barlev et al.   CELL DEATH AND DIFFERENTIATION

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

(2010) M Aoubala et al.   CELL DEATH AND DIFFERENTIATION

c-Abl tyrosine kinase in the DNA damage response: cell death and more

(2010) V Meltser et al.   CELL DEATH AND DIFFERENTIATION

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

(2010) P Gaub et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria

(2010) K John et al.   CELL DEATH AND DIFFERENTIATION

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

(2010) J-J Lee et al.   CELL DEATH AND DIFFERENTIATION

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

(2010) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

(2010) Cho-Rok Jung et al.   JOURNAL OF CLINICAL INVESTIGATION

Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA

(2010) Barbora Brodská et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Noxa: A Sweet Twist to Survival and More

(2010) Alfredo Gimenez-Cassina et al.   MOLECULAR CELL

Cancer: The blind spot of p53

(2010) Anton Berns   NATURE

Selective activation of p53-mediated tumour suppression in high-grade tumours

(2010) Melissa R. Junttila et al.   NATURE

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

(2010) R. Melero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-molecule characterization of p53 search on DNA

(2010) A. Tafvizi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts

(2010) J A Manning et al.   Cell Death & Disease

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

(2010) M Fricker et al.   Cell Death & Disease

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus

(2010) E C Bunk et al.   Cell Death & Disease

Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation

(2010) C E Barton et al.   Cell Death & Disease

p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma

(2010) D Meley et al.   Cell Death & Disease

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis

(2010) M Karlberg et al.   Cell Death & Disease

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis

(2010) V Tomlinson et al.   Cell Death & Disease

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

(2010) T Engel et al.   Cell Death & Disease

Ubiquitin-independent p53 proteasomal degradation

(2009) P Tsvetkov et al.   CELL DEATH AND DIFFERENTIATION

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

(2009) J Gao et al.   CELL DEATH AND DIFFERENTIATION

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

(2009) N D Marchenko et al.   CELL DEATH AND DIFFERENTIATION

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Phosphorylation and Stabilization of TAp63γ by IκB Kinase-β

(2008) Mary MacPartlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY