Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

MCM9 Mutations Are Associated with Ovarian Failure, Short Stature, and Chromosomal Instability

(2014) Michelle A. Wood-Trageser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs

(2014) Xiaoling Zhang et al.   BMC GENOMICS

Kisspeptin Receptor Haplo-insufficiency Causes Premature Ovarian Failure Despite Preserved Gonadotropin Secretion

(2014) Francisco Gaytan et al.   ENDOCRINOLOGY

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells

(2014) J. Garcia-Ortega et al.   HUMAN REPRODUCTION

Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability

(2014) Saleh AlAsiri et al.   JOURNAL OF CLINICAL INVESTIGATION

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

(2014) John R. B. Perry et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes

(2014) John D. Eicher et al.   NUCLEIC ACIDS RESEARCH

Multiple Regulation of Rad51-Mediated Homologous Recombination by Fission Yeast Fbh1

(2014) Yasuhiro Tsutsui et al.   PLoS Genetics

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

(2014) Karani S Vimaleswaran et al.   Lancet Diabetes & Endocrinology

Inherited Genetic Susceptibility to Breast Cancer

(2013) Maya Ghoussaini et al.   AMERICAN JOURNAL OF PATHOLOGY

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

(2013) John R.B. Perry et al.   HUMAN MOLECULAR GENETICS

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials

(2013) JoAnn E. Manson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

FBH1 Helicase Disrupts RAD51 Filamentsin Vitroand Modulates Homologous Recombination in Mammalian Cells

(2013) Jitka Simandlova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Approach to the Patient With Hypogonadotropic Hypogonadism

(2013) Letícia Ferreira Gontijo Silveira et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Do BRCA1 and BRCA2 Mutation Carriers Have Earlier Natural Menopause Than Their Noncarrier Relatives? Results From the Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer

(2013) Ian M. Collins et al.   JOURNAL OF CLINICAL ONCOLOGY

Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci

(2013) A. N. A. Monteiro et al.   JOURNAL OF INTERNAL MEDICINE

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

(2013) Rosalind A Eeles et al.   NATURE GENETICS

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

(2013) Kyriaki Michailidou et al.   NATURE GENETICS

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Body Mass Index, Exercise, and Other Lifestyle Factors in Relation to Age at Natural Menopause: Analyses From the Breakthrough Generations Study

(2012) D. H. Morris et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

(2012)   LANCET ONCOLOGY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

(2012) Lisette Stolk et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

(2012) Bryan Howie et al.   NATURE GENETICS

Integrative annotation of chromatin elements from ENCODE data

(2012) Michael M. Hoffman et al.   NUCLEIC ACIDS RESEARCH

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication Stress

(2011) Gulfem Dilek Guler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-resolution map of human evolutionary constraint using 29 mammals

(2011) Kerstin Lindblad-Toh et al.   NATURE

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

(2010) Ayellet V. Segrè et al.   PLoS Genetics

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks

(2009) Kutluk Oktay et al.   JOURNAL OF CLINICAL ONCOLOGY

Testing ovarian reserve to predict age at menopause

(2009) C.B. Lambalk et al.   MATURITAS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Genetics of reproductive lifespan

(2009) Patricia Hartge   NATURE GENETICS

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

The Ovary

(2008) Ozgur Oktem et al.   Annals of the New York Academy of Sciences

Genetic investigation of four meiotic genes in women with premature ovarian failure

(2008) Béatrice Mandon-Pépin et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP

(2008) Bastian Linder et al.   HUMAN MOLECULAR GENETICS

CHEK2*1100delC Genotyping for Clinical Assessment of Breast Cancer Risk: Meta-Analyses of 26,000 Patient Cases and 27,000 Controls

(2008) Maren Weischer et al.   JOURNAL OF CLINICAL ONCOLOGY

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

(2008) Naomi E. Rance   PEPTIDES