HIF-hypoxia signaling in skeletal muscle physiology and fibrosis

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

(2019) Daniela L. Rebolledo et al.   MATRIX BIOLOGY

Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1α-TAK1 signalling pathway

(2019) Xiaoying Yan et al.   CARDIOVASCULAR RESEARCH

The Renin-Angiotensin System: Going Beyond the Classical Paradigms

(2019) Robson A. Souza Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment

(2019) Dan Qi et al.   Cell Death & Disease

Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells

(2019) Geneviève Drouin et al.   Skeletal Muscle

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

(2019) Neil S. Sanghani et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer

(2019) Musbau Adewumi Akanji et al.   Oxidative Medicine and Cellular Longevity

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

(2019) Lauren B. Arendse et al.   PHARMACOLOGICAL REVIEWS

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers

(2019) Roger Valle-Tenney et al.   MATRIX BIOLOGY

HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes

(2019) Hao Huang et al.   BMC Pharmacology & Toxicology

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

(2018) Yunwen Yang et al.   CLINICAL SCIENCE

The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model

(2018) David Gonzalez et al.   HUMAN MOLECULAR GENETICS

Microvascular Permeability of Skeletal Muscle After Eccentric Contraction-Induced Muscle Injury: In Vivo Imaging Using Two-Photon Laser Scanning Microscopy

(2018) Kazuki Hotta et al.   JOURNAL OF APPLIED PHYSIOLOGY

Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration

(2018) Liwei Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases

(2018) Amit A. Joharapurkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of fibrosis in muscular dystrophy

(2018) Lucas R. Smith et al.   MATRIX BIOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Skeletal muscle fibrosis: an overview

(2018) Mohamed A. A. Mahdy   CELL AND TISSUE RESEARCH

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

(2018) Andrew N. Billin et al.   Skeletal Muscle

The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration

(2017) Xin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrosis development in early-onset muscular dystrophies: Mechanisms and translational implications

(2017) Antonio L. Serrano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ACE inhibition to slow progression of myocardial fibrosis in muscular dystrophies

(2017) Vincenzo Russo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts

(2017) Xu Mingyuan et al.   Oncotarget

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

(2017) David Gonzalez et al.   PLoS One

Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis

(2016) Felix Preisser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

(2016) Benjamin A. Olenchock et al.   CELL

Hypoxia in tissue repair and fibrosis

(2016) Ian A. Darby et al.   CELL AND TISSUE RESEARCH

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis

(2016) Osvaldo Contreras et al.   CELL AND TISSUE RESEARCH

Angiotensin-(1-7) attenuated long-term hypoxia-stimulated cardiomyocyte apoptosis by inhibiting HIF-1αnuclear translocation via Mas receptor regulation

(2016) Ruey-Lin Chang et al.   GROWTH FACTORS

Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways

(2016) Yi Cheng et al.   PLoS One

SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc

(2016) Chun-do Oh et al.   Scientific Reports

Comparative Study of Injury Models for Studying Muscle Regeneration in Mice

(2016) David Hardy et al.   PLoS One

HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo

(2015) A. J. Majmundar et al.   DEVELOPMENT

Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation

(2015) M. K. Rana et al.   JOURNAL OF CELL SCIENCE

SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β

(2015) Gonzalo Córdova et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

VEGF induces stress fiber formation in fibroblasts isolated from dystrophic muscle

(2015) Kelly M. Gutpell et al.   Journal of Cell Communication and Signaling

HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery

(2014) Henna Niemi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

(2014) Sherry Dadgar et al.   JOURNAL OF CELL BIOLOGY

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

(2014) Stefan Reischl et al.   PLoS One

ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis

(2014) Cecilia Riquelme et al.   PLoS One

Angiogenesis as a novel therapeutic strategy for Duchenne muscular dystrophy through decreased ischemia and increased satellite cells

(2014) Yuko Shimizu-Motohashi et al.   Frontiers in Physiology

Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

(2014) Patrizia Pessina et al.   Skeletal Muscle

Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

(2013) María Gabriela Morales et al.   CELL AND TISSUE RESEARCH

Cellular dynamics in the muscle satellite cell niche

(2013) C Florian Bentzinger et al.   EMBO REPORTS

Autonomic, locomotor and cardiac abnormalities in a mouse model of muscular dystrophy: targeting the renin-angiotensin system

(2013) Rasna Sabharwal et al.   EXPERIMENTAL PHYSIOLOGY

Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming

(2013) Antonios Matsakas et al.   FASEB JOURNAL

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

(2013) María José Acuña et al.   HUMAN MOLECULAR GENETICS

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

(2013) Maria Gabriela Morales et al.   HUMAN MOLECULAR GENETICS

Role of neuronal nitric oxide in the inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle of healthy rats

(2013) Nicholas G. Jendzjowsky et al.   JOURNAL OF APPLIED PHYSIOLOGY

Myeloid Hypoxia-Inducible Factor-1  Is Essential for Skeletal Muscle Regeneration in Mice

(2013) N. Scheerer et al.   JOURNAL OF IMMUNOLOGY

Requirement of Inducible Nitric Oxide Synthase for Skeletal Muscle Regeneration after Acute Damage

(2013) E. Rigamonti et al.   JOURNAL OF IMMUNOLOGY

Ambient hypoxia enhances the loss of muscle mass after extensive injury

(2013) T. Chaillou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional muscle ischemia in Duchenne and Becker muscular dystrophy

(2013) Gail D. Thomas   Frontiers in Physiology

Vascular-targeted therapies for Duchenne muscular dystrophy

(2013) James P Ennen et al.   Skeletal Muscle

Pharmacologic stabilization of HIF-1  increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

(2012) C. E. Forristal et al.   BLOOD

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

(2012) W Jeffrey Petty et al.   BMC CANCER

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Angiotensin II, Oxidative Stress and Skeletal Muscle Wasting

(2011) Sergiy Sukhanov et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent

(2011) Laura C. Semprun-Prieto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Silencing of Hypoxia-Inducible Factor-1α Gene Attenuated Angiotensin II–Induced Renal Injury in Sprague-Dawley Rats

(2011) Qing Zhu et al.   HYPERTENSION

Improved V̇O2 uptake kinetics and shift in muscle fiber type in high-altitude trekkers

(2011) C. Doria et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-β-dependent Signaling, and Inhibits TGF-β-dependent Fibrotic Response in Skeletal Muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia inducible factor 1α links fast-patterned muscle activity and fast muscle phenotype in rats

(2011) Ida G. Lunde et al.   JOURNAL OF PHYSIOLOGY-LONDON

O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling

(2011) A. J. Majmundar et al.   MOLECULAR AND CELLULAR BIOLOGY

Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

(2011) Anna Cozzoli et al.   PHARMACOLOGICAL RESEARCH

Nitric Oxide Sustains Long-Term Skeletal Muscle Regeneration by Regulating Fate of Satellite Cells Via Signaling Pathways Requiring Vangl2 and Cyclic GMP

(2011) Roberta Buono et al.   STEM CELLS

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Angiotensin-(1–7) upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats

(2010) María A. Costa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Muscle-specific expression of hypoxia-inducible factor in human skeletal muscle

(2010) Rémi Mounier et al.   EXPERIMENTAL PHYSIOLOGY

Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy

(2010) Carol G. Au et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

PGC-1  regulates a HIF2 -dependent switch in skeletal muscle fiber types

(2010) K. A. Rasbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathy

(2009) Ralf Bauer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Angiotensin-(1-7) Prevents Cardiomyocyte Pathological Remodeling Through a Nitric Oxide/Guanosine 3′,5′-Cyclic Monophosphate–Dependent Pathway

(2009) Enéas R.M. Gomes et al.   HYPERTENSION

Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors

(2009) Cristina Borselli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Involved in the Angiotensin-(1-7)/Mas Signaling Pathway in Cardiomyocytes

(2008) Marco F. Dias-Peixoto et al.   HYPERTENSION

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

(2008) Cesare Gargioli et al.   NATURE MEDICINE

HIF-1 regulation: not so easy come, easy go

(2008) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

(2007) Cecilia Vial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES