Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice

(2012) Emeka K. Enwere et al.   HUMAN MOLECULAR GENETICS

NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9

(2012) Lara Kular et al.   Journal of Neuroinflammation

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

(2011) Claudio Cabello-Verrugio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity

(2011) Cecilia Vial et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

(2011) María Gabriela Morales et al.   JOURNAL OF PATHOLOGY

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Phase 1 Study of Anti-CTGF Monoclonal Antibody in Patients with Diabetes and Microalbuminuria

(2010) S. G. Adler et al.   Clinical Journal of the American Society of Nephrology

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

(2010) Y Tang et al.   GENE THERAPY

A Novel Mechanism of Sequestering Fibroblast Growth Factor 2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation

(2010) J. Gutierrez et al.   MOLECULAR AND CELLULAR BIOLOGY

The Survival of Myoblasts After Intramuscular Transplantation Is Improved When Fewer Cells Are Injected

(2010) Kathryn L. Pellegrini et al.   TRANSPLANTATION

Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes

(2010) Xiaoyu Wang et al.   Journal of Cell Communication and Signaling

Mammalian animal models for Duchenne muscular dystrophy

(2009) Raffaella Willmann et al.   NEUROMUSCULAR DISORDERS

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines

(2009) Chih-Chiun Chen et al.   Journal of Cell Communication and Signaling

Real-time PCR to determine transgene copy number and to quantitate the biolocalization of adoptively transferred cells from EGFP-transgenic mice

(2008) Molishree U. Joshi et al.   BIOTECHNIQUES

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

(2008) Xu Shi-Wen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Connective tissue growth factor: Structure–function relationships of a mosaic, multifunctional protein

(2008) Patricia De Winter et al.   GROWTH FACTORS

Functions and mechanisms of action of CCN matricellular proteins

(2008) Chih-Chiun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor‐β‐induced mouse fibrosis

(2008) Yuka Ikawa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Connective Tissue Growth Factor Is Necessary for Retinal Capillary Basal Lamina Thickening in Diabetic Mice

(2008) Esther J. Kuiper et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

N-Acetylcysteine ameliorates skeletal muscle pathophysiology inmdxmice

(2008) Nicholas P. Whitehead et al.   JOURNAL OF PHYSIOLOGY-LONDON

PlGF–MMP-9–expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

(2008) Cesare Gargioli et al.   NATURE MEDICINE

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

(2007) Cecilia Vial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES