SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β

The humanNUPR1/P8gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway

(2015) Roxane M. Pommier et al.   BIOCHEMICAL JOURNAL

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription

(2014) Azahara Fernández-Guizán et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

(2014) Guangxing Bai et al.   GENE

CCN2: a novel, specific and valid target for anti-fibrotic drug intervention

(2013) Andrew Leask   EXPERT OPINION ON THERAPEUTIC TARGETS

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

(2013) Maria Gabriela Morales et al.   HUMAN MOLECULAR GENETICS

Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis

(2013) Pedro Cisternas et al.   MOLECULAR NEUROBIOLOGY

Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements

(2012) Michel Fausther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Controversial Role of Retinoic Acid in Fibrotic Diseases: Analysis of Involved Signaling Pathways

(2012) Tian-Biao Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Expression of Genes Involved in the Degeneration and Regeneration Pathways in Mouse Models for Muscular Dystrophies

(2012) P. C. G. Onofre-Oliveira et al.   NEUROMOLECULAR MEDICINE

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

(2012) A Sundqvist et al.   ONCOGENE

The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-β-dependent Signaling, and Inhibits TGF-β-dependent Fibrotic Response in Skeletal Muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles

(2011) Claudio Cabello-Verrugio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

(2011) S. F. Sleiman et al.   JOURNAL OF NEUROSCIENCE

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

(2011) María Gabriela Morales et al.   JOURNAL OF PATHOLOGY

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

A potent enhancer element in the 5′-UTR intron is crucial for transcriptional regulation of the human ubiquitin C gene

(2009) Marzia Bianchi et al.   GENE

The human α11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-β1 in a Smad- and Sp1-dependent manner

(2009) Ning Lu et al.   MATRIX BIOLOGY

TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3–Sp1–KLF6 interaction

(2008) Luisa M. Botella et al.   BIOCHEMICAL JOURNAL

Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation

(2007) Cecilia Vial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES